Results 41 to 50 of about 15,145 (185)
Frontiers in Pharmacology, 2019 Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE ...
Timothy B. C. Johnstone +6 more
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Tonic neuromodulation of the inspiratory rhythm generator
Frontiers in Physiology, 2012 The generation of neural network dynamics relies on the interactions between the intrinsic and synaptic properties of their neural components. Moreover, neuromodulators allow networks to change these properties and adjust their activity to specific ...
Fernando ePeña-Ortega
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Thinking Outside the Synapse: Glycine at Extrasynaptic NMDA Receptors [PDF]
, 2012 In this issue, Papouin et al. show that glycine is the endogenous coagonist for extrasynaptic NMDA receptors (NMDARs), unlike at synapses where the coagonist is d-serine.
Gray, John A., Nicoll, Roger A.
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Frontiers in Cellular Neuroscience, 2014 The soma of many neurons releases large amounts of transmitter molecules through an exocytosis process that continues for hundreds of seconds after the end of the triggering stimulus.
Carolina eLeon-Pinzon +4 more
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Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts. [PDF]
, 2006 GABAA receptors mediate the majority of fast synaptic inhibition in the brain. The accumulation of these ligand-gated ion channels at synaptic sites is a prerequisite for neuronal inhibition, but the molecular mechanisms underlying this phenomenon remain
Haydon, PG +6 more
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Photo-antagonism of the GABAA receptor [PDF]
, 2014 Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
Topf, Maya +15 more
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Frontiers in Behavioral Neuroscience, 2014 Dopamine mediates diverse functions such as motivation, reward, attention, learning/memory and sleep/arousal. Recent studies using model organisms including the fruit fly, have elucidated various physiological functions of dopamine, and identified ...
Taro eUeno +3 more
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Extrasynaptic site of action for γ-hydroxybutyrate [PDF]
Proceedings of the National Academy of Sciences, 2012 Advances in pharmacology often result from identifying the mechanism of action of drugs found empirically to be biologically active (1). γ-Hydroxybutyric acid (GHB), also known as Fantasy, is a centrally active agent that has been used clinically and recreationally for nearly half a century.
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Organization, control and function of extrasynaptic NMDA receptors [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 N -methyl d -aspartate receptors (NMDARs) exist in different forms owing to multiple combinations of subunits that can assemble into a functional receptor. In addition, they are located not only at synapses but also at extrasynaptic sites.
Papouin, Thomas, Oliet, Stéphane
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Pathophysiological power of improper tonic GABAA conductances in mature and immature models
Frontiers in Neural Circuits, 2013 High-affinity extrasynaptic gamma-aminobutyric acid A (GABAA) receptors are tonically activated by low and consistent levels of ambient GABA, mediating chronic inhibition against neuronal excitability (tonic inhibition) and the modulation of neural ...
Kiyoshi eEgawa, Atsuo eFukuda
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