Results 41 to 50 of about 14,388 (200)
Frontiers in Neuroscience, 2020 The consequence of repeated cocaine exposure and prolonged abstinence on glutamate receptor expression in the nucleus accumbens has been extensively studied. However, the early effects of cocaine on NMDAR signaling remain unknown. NMDAR signaling depends
Ilse Delint-Ramirez +5 more
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Oligomerization and cell surface expression of recombinant GABAA receptors tagged in the δ subunit
Journal of Integrative Neuroscience, 2019 The γ-Aminobutyric acid type A receptors (GABAARs) are heteropentameric chloride channels responsible for primary inhibition in the mammalian brain.
Furkan Enes Oflaz +2 more
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Frontiers in Pharmacology, 2019 Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE ...
Timothy B. C. Johnstone +6 more
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Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts. [PDF]
, 2006 GABAA receptors mediate the majority of fast synaptic inhibition in the brain. The accumulation of these ligand-gated ion channels at synaptic sites is a prerequisite for neuronal inhibition, but the molecular mechanisms underlying this phenomenon remain
Haydon, PG +6 more
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Tonic neuromodulation of the inspiratory rhythm generator
Frontiers in Physiology, 2012 The generation of neural network dynamics relies on the interactions between the intrinsic and synaptic properties of their neural components. Moreover, neuromodulators allow networks to change these properties and adjust their activity to specific ...
Fernando ePeña-Ortega
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, 2015 GABAA receptors are important for inhibition in the CNS where neurosteroids and protein kinases are potent endogenous modulators. Acting individually, these can either enhance or depress receptor function, dependent upon the type of neurosteroid or ...
Adams, JM +5 more
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Frontiers in Cellular Neuroscience, 2014 The soma of many neurons releases large amounts of transmitter molecules through an exocytosis process that continues for hundreds of seconds after the end of the triggering stimulus.
Carolina eLeon-Pinzon +4 more
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Extrasynaptic site of action for γ-hydroxybutyrate [PDF]
Proceedings of the National Academy of Sciences, 2012 Advances in pharmacology often result from identifying the mechanism of action of drugs found empirically to be biologically active (1). γ-Hydroxybutyric acid (GHB), also known as Fantasy, is a centrally active agent that has been used clinically and recreationally for nearly half a century.
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Frontiers in Behavioral Neuroscience, 2014 Dopamine mediates diverse functions such as motivation, reward, attention, learning/memory and sleep/arousal. Recent studies using model organisms including the fruit fly, have elucidated various physiological functions of dopamine, and identified ...
Taro eUeno +3 more
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Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors.
, 2022 Type A GABA (γ-aminobutyric acid) receptors represent a diverse population in the mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ- and π-subunits1. αβ, α4βδ, α6βδ and α5βγ receptors favour extrasynaptic localization, and
Smart, Trevor G +7 more
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