Results 51 to 60 of about 15,145 (185)
Extracellular space diffusion and extrasynaptic transmission
Physiological Research, 2008 The diffusion of neuroactive substances in the extracellular space (ECS) plays an important role in short- and long-distance communication between nerve cells and is the underlying mechanism of extrasynaptic (volume) transmission. The diffusion properties of the ECS are described by three parameters: 1. ECS volume fraction alpha (alpha=ECS volume/total
L, Vargová, E, Syková
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Extrasynaptic Neurotransmission as a Way of Modulating Neuronal Functions [PDF]
Frontiers in Physiology, 2012 Extrasynaptic neurotransmission allows neuronal communication at variable distances, based on the release and diffusion of chemical substances from the soma, axon, or dendrites of neurons, or after transmitter leak-out from the synaptic cleft (De-Miguel and Trueta, 2005; Fuxe et al., 2007).
De-Miguel, Francisco F., Fuxe, Kjell
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Fast detection of extrasynaptic GABA with a whole-cell sniffer
Frontiers in Cellular Neuroscience, 2014 Gamma-amino-butyric acid (GABA) is the main inhibitory transmitter of the brain. It operates by binding to specific receptors located both inside and outside synapses.
Rasmus Kordt Christensen +3 more
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Journal of Neuroinflammation, 2020 Background A subanesthetic dose of ketamine provides rapid and effective antidepressant effects, but the molecular mechanism remains elusive. It has been reported that overactivation of extrasynaptic GluN2B receptors is associated with the antidepressant
Xiao-Hui Tang +7 more
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Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]
, 2011 GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Errington, Adam C. +2 more
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Thermodynamic Efficiency of Somatic Exocytosis of Serotonin
Frontiers in Physiology, 2019 Through somatic exocytosis neurons liberate immense amounts of transmitter molecules that modulate the functioning of the nervous system. A stream of action potentials triggers an ATP-dependent transport of transmitter-containing vesicles to the plasma ...
Paula Noguez +2 more
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Pharmaceuticals, 2023 With the discovery that the acquisition of toxic features by extrasynaptic NMDA receptors (NMDARs) involves their physical interaction with the non-selective cation channel, TRPM4, it has become possible to develop a new pharmacological principle for ...
Jing Yan, Hilmar Bading
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Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders [PDF]
, 2010 There is a long-standing paradox that NMDA (N-methyl-D-aspartate) receptors (NMDARs) can both promote neuronal health and kill neurons. Recent studies show that NMDAR-induced responses depend on the receptor location: stimulation of synaptic NMDARs ...
Bading, H. +3 more
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Functional properties and pharmacology of extrasynaptic GABA-A receptors [PDF]
, 2012 The “ambient” GABA that is present in the extracellular space surrounding all neurons of the brain is believed to be capable of persistently activating high‐affinity extrasynaptic GABA-A receptors to generate a tonic membrane conductance.
McGee, Thomas Patrick
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Extrasynaptic NMDA Receptors : Mediators of Excitotoxic Cell Death [PDF]
, 2004 The N-methyl-D-aspartate (NMDA) type of glutamate receptor is a calcium-permeable ion channel with important functions in the physiology and pathology of the mammalian brain.
Wittmann, Malte +2 more
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