Results 71 to 80 of about 15,145 (185)
eLife, 2017 Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and ...
Sang Hak Lee +15 more
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A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling
Molecular Brain, 2020 The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell ...
Carlos Bas-Orth +4 more
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Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus. [PDF]
PLoS ONE, 2011 Neural inhibition plays an important role in auditory processing and attentional gating. Extrasynaptic GABA(A) receptors (GABA(A)R), containing α(4)and δ GABA(A)R subunits, are thought to be activated by GABA spillover outside of the synapse following ...
Ben D Richardson +3 more
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Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease [PDF]
, 2012 Over the past two decades, research has identified extrasynaptic GABAA receptor populations that enable neurons to sense the low ambient GABA concentrations present in the extracellular space in order to generate a form of tonic inhibition not previously
Brickley, Stephen G., Mody, Istvan
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Frontiers in Cellular NeuroscienceGABAA receptors (γ-aminobutyric acid-gated receptors type A; GABAARs), the major structural and functional postsynaptic components of inhibitory synapses in the mammalian brain, belong to a family of GABA-gated Cl−/HCO3− ion channels.
Yusheng Sui +5 more
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Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons
Scientific Reports, 2017 In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs
Qian Yang +11 more
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Neurobiology of Disease, 2018 Rett syndrome (RTT) is a devastating neurodevelopmental disorder caused by loss-of-function mutations in the X-linked methyl-CpG binding protein 2 (Mecp2) gene.
Chao-Yin Chen +6 more
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Frontiers in Synaptic Neuroscience, 2019 N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic signaling, and alterations in the synaptic/extrasynaptic NMDAR balance affect neuronal survival.
Rujun Kang +5 more
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Distribution of AMPA Receptor Subunits and Tarps in Synaptic and Extrasynaptic Membranes of the Adult Rat Nucleus Accumbens [PDF]
, 2011 We characterized the distribution of AMPA receptor (AMPAR) subunits and the transmembrane AMPA receptor regulatory proteins (TARPs) γ-2 and γ-4 in adult rat nucleus accumbens (NAc) using a method that separates plasma membranes into synaptic membrane ...
Wolf, Marina +9 more
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Insulin Regulates GABAA Receptor-Mediated Tonic Currents in the Prefrontal Cortex
Frontiers in Neuroscience, 2018 Recent studies, have shown that insulin increases extrasynaptic GABAA receptor-mediated currents in the hippocampus, causing alterations of neuronal excitability.
Saraí Trujeque-Ramos +6 more
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