Results 91 to 100 of about 15,145 (185)

contribution des récepteurs NMDA extrasynatiques à l'activité en bouffée dans les neurones dopaminergiques de la substance noire compacte

Movement initiation is preceded by bursting activity and increased dopamine release by substantia nigra pars compacta neurons. The participation of NMDARs is essential to the generation of bursts but the mechanisms regulating their level of activation ...
Engel, Dominique
core   +1 more source

Thalamic extrasynaptic GABAA receptors are required for typical absence seizures [PDF]

, 2009
Aberrant GABAergic inhibition in thalamo-cortical networks has been identified as a potential mechanism for spike-and-wave discharge (SWD) generation. Thalamocortical (TC) neurons in the ventrobasal (VB) thalamus receive both ‘phasic’ and ‘tonic’ GABAA ...
Cope, David W., Physiological Society Symposium, Di Giovanni, Giuseppe, Crunelli, Vincenzo, Fyson, Sarah J., Orban, Gergely   +5 more
core  

Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations

, 2017
Activation of extrasynaptic N-methyl-d-aspartate (NMDA) receptors causes neurodegeneration and cell death. The disease mechanism involves a pathological triad consisting of mitochondrial dysfunction, loss of integrity of neuronal structures and ...
Hilmar Bading
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Extrasynaptic receptors on cell bodies of neurons in central nervous system of the leech

, 1977
1. A systematic study has been made of the sensitivity of identified sensory and motoneurons in the leech central nervous system to chemical transmitter substances. 2.
P. B. Sargent, J. G. Nicholls, K. W. Yau
core   +1 more source

Optochemical profiling of NMDAR molecular diversity at synaptic and extrasynaptic sites

The EMBO Journal
Neurotransmitter receptors are critical for neuronal communication. They often form large multimeric complexes that differ in their subunit composition, distribution, and signaling properties. N‐methyl‐D‐aspartate receptors (NMDARs), a class of glutamate-
Antoine Sicard, Meilin Tian, Zakaria Mostefai, Sophie Shi, Cécile Cardoso, Joseph Zamith, Isabelle McCort-Tranchepain, Cécile Charrier, Pierre Paoletti, Laetitia Mony   +9 more
doaj   +1 more source

The role of extrasynaptic NMDA receptors in synaptic transmission and plasticity

, 2009
Receptors located outside of the synapse are a ubiquitous but poorly understood feature of the nervous system. In this thesis, I investigate the sub-cellular distribution of N-methyl-D-aspartate receptors (NMDARs), a molecule critical for neural function,
Harris, Alexander Z.
core  

NMDARs in Alzheimer’s Disease: Between Synaptic and Extrasynaptic Membranes

N-methyl-D-aspartate receptors (NMDARs) are glutamate receptors with key roles in synaptic communication and plasticity. The activation of synaptic NMDARs initiates plasticity and stimulates cell survival.
Cuchillo-Ibáñez, Inmaculada, Sergio Escamilla, Sáez-Valero, Javier, Javier Sáez-Valero, Inmaculada Cuchillo-Ibáñez, Escamilla, Sergio   +5 more
core   +1 more source

Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in co-cultured striatal and cortical neurons

, 2011
The N-methyl-d-aspartate receptor- type glutamate receptor (NMDAR) plays a unique and vital role in subcellular signaling. Ca²⁺ influx initiates signaling cascades important for synaptic plasticity and survival.
Kaufman, Alexandra
core   +1 more source

Glutamate tone in preBötzinger complex rhythmogenesis: ambient extracellular glutamate as a candidate excitability bias. [PDF]

Pflugers Arch
Vázquez-Mendoza E, Olmos-Pastoresa CA, Chí-Castañeda D, López-Meraz ML, Beltran-Parrazal L, Morgado-Valle C.   +5 more
europepmc   +1 more source

Synaptic vs. Non-Synaptic Glycine Receptors: Physiological Role and Implications in Alzheimer's Disease Pathology. [PDF]

Int J Mol Sci
Kiss E, Kirsch J, Kins S, Kuhse J.
europepmc   +1 more source