Results 101 to 110 of about 22,128 (213)

Agrin binds to the nerve-muscle basal lamina via laminin [PDF]

, 1997
Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Altschul, Bowe, Bowe, Bowen, Brancaccio, Brandenberger, Brandenberger, Brubacher, Burden, Burgeson, Campagna, Campanelli, Campbell, Chiu, Cohen, Cohen, Denzer, Denzer, Ferns, Fox, Gautam, Gee, Gesemann, Gesemann, Gluzman, Godfrey, Godfrey, Godfrey, Godfrey, Graham, Hagen, Halfter, Hall, Hunter, Kleinman, Lennon, Lowry, Magill-Solc, Martin, Martin, McMahan, McMahan, Morrissey, Nitkin, Nitkin, Noakes, Ott, Paulsson, Pearson, Perris, Reist, Ries, Ruegg, Ruegg, Ruegg, Rupp, Sanes, Sanes, Sanes, Schuler, Smith, Sugiyama, Timpl, Timpl, Timpl, Tsen, Tsen, Tsim, Wallace, Wallace, Weber, Worton, Yurchenco, Yurchenco   +73 more
core   +3 more sources

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Astrocyte Proximity Protects Synapses From Human Amyloid‐Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease

European Journal of Neuroscience, Volume 63, Issue 7, April 2026.
Alzheimer's disease (AD) is the most common cause of dementia, affecting over 35 million people worldwide. A key feature of AD is the loss of synapses—the connections between brain cells—which strongly correlates with cognitive decline. We sought to investigate the role of astrocytes in mouse organotypic cultures challenged with brain homogenate (BH ...
Francesco Gobbo, Declan King, Jane Tulloch, Davide Gobbo, Calum Bonthron, Soraya Meftah, Caleb Stoddart‐Campbelton, Arisa Tamura, Jamie Rose, Colin Smith, Claire Durrant, Tara L. Spires‐Jones   +11 more
wiley   +1 more source

Insulin Regulates GABAA Receptor-Mediated Tonic Currents in the Prefrontal Cortex

Frontiers in Neuroscience, 2018
Recent studies, have shown that insulin increases extrasynaptic GABAA receptor-mediated currents in the hippocampus, causing alterations of neuronal excitability.
Saraí Trujeque-Ramos, Diego Castillo-Rolón, Elvira Galarraga, Dagoberto Tapia, Gabina Arenas-López, Stefan Mihailescu, Salvador Hernández-López   +6 more
doaj   +1 more source

The Predominance of Electric Transport in Synaptic Transmission [PDF]

, 2009
The quantitative description of the motion of neurotransmitters in the synaptic cleft appears to be one of the most difficult problems in the modeling of synapses.
Hamid Reza Noori
core   +1 more source

In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death [PDF]

, 2009
It has been suggested that NR2B-containing N-methyl-d-aspartate (NMDA) receptors have a selective tendency to promote pro-death signaling and synaptic depression, compared with the survival promoting, synapse potentiating properties of NR2A-containing ...
Hardingham, G.E., Martel, M.-A., Wyllie, D.J.A.   +2 more
core   +1 more source

Advances in hiPSC‐Derived Brain Organoids as a Model to Study Neuroinflammation in Alzheimer's Disease

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Brain organoids and assembloids derived from human induced pluripotent stem cells (hiPSCs) represent a striking advance in biomedical research. These technologies allow a more accurate mimicry of the three‐dimensional cellular environment in vitro, enabling detailed investigations of Alzheimer's disease (AD) pathological features, such as β‐amyloid ...
Esther Marques Alves Maciel, Nathália Costa Silva, Luiz Gustavo Pontes Santos, Fabiola M. Ribeiro   +3 more
wiley   +1 more source

DMV extrasynaptic NMDA receptors regulate caloric intake in rats

JCI Insight, 2021
Acute high-fat diet (aHFD) exposure induces a brief period of hyperphagia before caloric balance is restored. Previous studies have demonstrated that this period of regulation is associated with activation of synaptic N-methyl-D-aspartate (NMDA ...
Courtney Clyburn, R. Alberto Travagli, Amy C. Arnold, Kirsteen N. Browning   +3 more
doaj   +1 more source

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]

, 2016
Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core   +1 more source

Targeting Glutamate Excitotoxicity With Memantine Modulates Glial Response and Protects Motoneurons After Spinal Root Lesion

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Motoneuron axotomy induced marked neuroinflammation, synaptic withdrawal, and structural remodeling in the ventral root crush (VRC) model, characterized by intense microglial and astroglial activation and reduced synaptic coverage. Memantine treatment produced consistent, dose‐dependent neuroprotection, with maximal effects at 45 mg/kg.
Arthur Ventura Martins Leão, Gabriel Gaspar Bíscaro, Alexandre Leite Rodrigues de Oliveira, Luciana Politti Cartarozzi   +3 more
wiley   +1 more source