Results 121 to 130 of about 22,128 (213)

Sharing vesicles between central presynaptic terminals: implications for synaptic function

Frontiers in Synaptic Neuroscience, 2010
Presynaptic terminals in hippocampal neurons house functionally distinct vesicle pools, the size, structure and biochemical features of which are major determinants of presynaptic strength and performance.
Kevin Staras, Tiago Branco, Tiago Branco
doaj   +1 more source

Astrocytic Ca2+ waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia

Neurobiology of Disease, 2013
Excitotoxicity plays a central role in the neuronal damage during ischemic stroke. Although growing evidence suggests that activation of extrasynaptic NMDA receptors initiates neuronal death, no direct evidence demonstrated their activation during ...
Qi-ping Dong, Jing-quan He, Zhen Chai
doaj   +1 more source

Excitable Media Seminar [PDF]

, 2012
The simulation data presented here, and the conceptual framework developed for their interpretation are, both, in need of substantial refinement and extension.
Werner, prof. Gerhard
core  

Modulating anxiety with extrasynaptic inhibition

, 2014
Traumatic experiences and stress can lead to complex behavioral adaptations, including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes are, however, poorly understood. Numerous studies have indicated that, in both animals and humans, the amygdala is a key brain structure ...
openaire   +3 more sources

Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats

The Journal of Headache and Pain
Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA receptors.
Berkay Alpay, Bariscan Cimen, Elif Akaydin, Filiz Onat, Hayrunnisa Bolay, Yildirim Sara   +5 more
doaj   +1 more source

Targeting γ-aminobutyric acid type A receptors to mitigate perioperative neurocognitive disorders: a narrative review. [PDF]

Br J Anaesth
Ba J, Brenna CTA, Kaustov L, Wang DS, Orser BA.   +4 more
europepmc   +1 more source

Wakefulness is governed by GABA and histamine co-transmission [PDF]

, 2015
Brickley, SG, Franks, NP, Houston, CM, Ma, Y, Parker, S, Uygun, DS, Vyssotski, AL, Wisden, W, Yu, X, Yustos, Y, Zecharia, AY, Zhang, Z, Zhiwen, Y   +12 more
core   +1 more source

Extrasynaptic dopamine and phasic neuronal activity [PDF]

Nature Neuroscience, 2004
Paul E M Phillips, R Mark Wightman
openaire   +1 more source

Extracellular space diffusion modelling identifies distinct functional advantages of glutamatergic and GABAergic synapse geometries. [PDF]

Fluids Barriers CNS
Gimenez P, Shakya RT, Santamaria F, Tønnesen J.   +3 more
europepmc   +1 more source

Guanidino compounds with native GABA(A) δ receptor selectivity: a tale of homeostatic compensation in δ-KO mice. [PDF]

BMC Neurosci
Meera P, Uusi-Oukari M, Wallner M, Lipshutz GS.   +3 more
europepmc   +1 more source