Results 81 to 90 of about 12,399 (169)

Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons

Frontiers in Physiology, 2012
Persistent peripheral inflammation changes AMPA receptor (AMPAR) trafficking in dorsal horn neurons by promoting internalization of GluR2-containing, Ca2+-impermeable AMPARs from the synapses and by increasing insertion of GluR1-containing, Ca2 ...
Olga eKopach, Viacheslav eViatchenko-Karpinski, Pavel eBelan, Nana eVoitenko   +3 more
doaj   +1 more source

Dendritic signaling in inhibitory interneurons: local tuning via group I metabotropic glutamate receptors

Frontiers in Physiology, 2012
Communication between neurons is achieved by rapid signal transduction via highly specialized structural elements known as synaptic contacts. In addition, numerous extrasynaptic mechanisms provide a flexible platform for the local regulation of synaptic ...
Olivier eCamiré, Jean-Claude eLacaille, Lisa eTopolnik   +2 more
doaj   +1 more source

Extrasynaptic distribution of monoamine transporters and receptors

, 2000
Publisher Summary Extra-synaptic, as well as synaptic sites for monoaminergic transmission have been elucidated by using electron microscopic immunocytochemistry for the localization of sequence specific antipeptide antisera against recently cloned vesicular and plasmalemmal monoamine transporters and receptors.
openaire   +2 more sources

NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content

Cell Reports, 2019
Summary: In mature neurons, postsynaptic N-methyl-D-aspartate receptors (NMDARs) are segregated into two populations, synaptic and extrasynaptic, which differ in localization, function, and associated intracellular cascades. These two pools are connected
Andrew M. Chiu, Jiejie Wang, Michael P. Fiske, Pavla Hubalkova, Levi Barse, John A. Gray, Antonio Sanz-Clemente   +6 more
doaj   +1 more source

Extrasynaptic glutamate receptor activation as cellular bases for dynamic range compression in pyramidal neurons

Frontiers in Physiology, 2012
Repetitive synaptic stimulation overcomes the ability of astrocytic processes to clear glutamate from the extracellular space, allowing some dendritic segments to become submerged in a pool of glutamate.
Katerina D Oikonomou, Shaina M Short, Matthew T Rich, Srdjan D Antic   +3 more
doaj   +1 more source

Sharing vesicles between central presynaptic terminals: implications for synaptic function

Frontiers in Synaptic Neuroscience, 2010
Presynaptic terminals in hippocampal neurons house functionally distinct vesicle pools, the size, structure and biochemical features of which are major determinants of presynaptic strength and performance.
Kevin Staras, Tiago Branco, Tiago Branco
doaj   +1 more source

Extrasynaptic Release of GABA by Retinal Dopaminergic Neurons

Journal of Neurophysiology, 2009
GABA release by dopaminergic amacrine (DA) cells of the mouse retina was detected by measuring Cl−currents generated by isolated perikarya in response to their own neurotransmitter. The possibility that the Cl−currents were caused by GABA release from synaptic endings that had survived the dissociation of the retina was ruled out by examining confocal ...
Hajime, Hirasawa, Michelino, Puopolo, Elio, Raviola   +2 more
openaire   +3 more sources

Modulating anxiety with extrasynaptic inhibition

, 2014
Traumatic experiences and stress can lead to complex behavioral adaptations, including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes are, however, poorly understood. Numerous studies have indicated that, in both animals and humans, the amygdala is a key brain structure ...
openaire   +2 more sources

Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats

The Journal of Headache and Pain
Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA receptors.
Berkay Alpay, Bariscan Cimen, Elif Akaydin, Filiz Onat, Hayrunnisa Bolay, Yildirim Sara   +5 more
doaj   +1 more source

Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments. [PDF]

Pharmacol Res Perspect
Okada M, Okubo R, Oka T, Motomura E.
europepmc   +1 more source