Results 81 to 90 of about 22,128 (213)

Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes

eLife, 2017
Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and ...
Sang Hak Lee, Chaoyi Jin, En Cai, Pinghua Ge, Yuji Ishitsuka, Kai Wen Teng, Andre A de Thomaz, Duncan Nall, Murat Baday, Okunola Jeyifous, Daniel Demonte, Christopher M Dundas, Sheldon Park, Jary Y Delgado, William N Green, Paul R Selvin   +15 more
doaj   +1 more source

Behavioral Domain‐Specific Effects of Positive Modulation of α5 and α6 GABAA Receptors in a Rat Double‐Hit Stress Model

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
A double‐hit stress model in Sprague–Dawley rats induces alterations in motivation, motor impulsivity, and social recognition that are partially ameliorated by α5‐ and α6‐GABAA receptor modulation, suggesting domain‐specific effects of this modulation on the stress‐induced phenotype. ABSTRACT Impulsivity is an understudied area of post‐traumatic stress
Đorđe Đorović, Jovana Aranđelović, Jana Ivanović, Kristina Jezdić, Bojan Batinić, Dishary Sharmin, Prithu Mondal, James M. Cook, Miroslav M. Savić   +8 more
wiley   +1 more source

A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling

Molecular Brain, 2020
The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell ...
Carlos Bas-Orth, Mirja Koch, David Lau, Bettina Buchthal, Hilmar Bading   +4 more
doaj   +1 more source

Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus. [PDF]

PLoS ONE, 2011
Neural inhibition plays an important role in auditory processing and attentional gating. Extrasynaptic GABA(A) receptors (GABA(A)R), containing α(4)and δ GABA(A)R subunits, are thought to be activated by GABA spillover outside of the synapse following ...
Ben D Richardson, Lynne L Ling, Victor V Uteshev, Donald M Caspary   +3 more
doaj   +1 more source

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]

, 2017
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe, Beneventano, Martina, Bruno, Valeria, Bucci, Domenico, Di Pietro, Paola, Liberatore, Francesca, Madonna, Michele, Mascio, Giada, Nicoletti, Ferdinando, Puliti, Alda Maria, Romano, Maria Rosaria   +10 more
core   +1 more source

Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (noncompetitive NMDA receptor inhibitor), memantine (low‐affinity extrasynaptic‐NMDA ...
Motohiro Okada, Ruri Okubo, Tomoka Oka, Eishi Motomura   +3 more
wiley   +1 more source

FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]

, 2014
The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca, Liu, Xiaoqian, Lobner, Doug   +2 more
core   +1 more source

Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex [PDF]

, 2013
Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that
A Araque, A Kulak, A Wilmsmeier, B Moghaddam, B Moghaddam, B Oranje, BJ Morris, D Braff, D Lobner, D Matsuzawa, D Piani, DA Baker, DA Baker, David A. Baker, DH Ingvar, DL Braff, DV Pow, FK Graham, G Battaglia, G Franzen, G Paxinos, G Paxinos, G Rajkowska, HH Chen, J Cilia, JA Lieberman, JH Cabungcal, JI Sagara, Jon Resch, JT Coyle, K Japha, K Moussawi, K Moussawi, K Ogita, K Schwabe, K Shimosato, KE Poskanzer, KF Berman, KQ Do, Krista Qualmann, KS Kau, L Deserno, L Pasti, LA Glantz, Linghai Kong, LJ Garey, M Berk, M Berk, M Koch, M Li, M Raffa, MA Geyer, MC Angulo, ME Jackson, MJ Marino, MM Moran, NA Oberheim, NM Veelen van, NR Swerdlow, NR Swerdlow, NR Swerdlow, NR Swerdlow, O Kranich, P Bezzi, P Steullet, R Bridges, R Gysin, R Janaky, S Bannai, S Bannai, S Bannai, SG Potkin, SuJean Choi, T Majic, V Kumari, V Parpura, Victoria Lutgen, VM Goghari, VP Bakshi, WE Bunney, Y Cho, ZC Ye   +81 more
core   +2 more sources

Conservation of Neuron‐Astrocyte Correlated Activity in Developing Sensory Pathways

Glia, Volume 74, Issue 5, May 2026.
Astrocytes and neurons in the superior colliculus exhibit spatiotemporal correlated activity before eye opening. Each neuronal wave is followed by a calcium wave in astrocytes. Spillover of glutamate activates mGluR5 and mGluR3 in astrocytes. ABSTRACT Neurons in developing sensory organs exhibit prolonged burst firing before the onset of sensory ...
Vered Kellner, Patrick Parker, Dongeun Heo, Xuelong Mi, Mikhail Coen, Guoqiang Yu, Gesine Saher, Loyal A. Goff, Dwight E. Bergles   +8 more
wiley   +1 more source

Astrocytes and extracellular matrix in extrasynaptic volume transmission [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2014
Volume transmission is a form of intercellular communication that does not require synapses; it is based on the diffusion of neuroactive substances across the brain extracellular space (ECS) and their binding to extrasynaptic high-affinity receptors on neurons or glia.
Lýdia, Vargová, Eva, Syková
openaire   +2 more sources