Results 81 to 90 of about 14,388 (200)

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents [PDF]

, 2013
Activation of GABAA receptors (GABAARs) produces two forms of inhibition: ‘phasic’ inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic GABA release, and tonic inhibition generated by the persistent activation of ...
Herd, Murray B, Belelli, D., Wlodarczyk, A. I., Sylantyev, S., Linthorst, Astrid C.E., Walker, Matthew C., Walker, M. C., Rusakov, Dmitri A, Lambert, Jeremy J, Wlodarczyk, Agnieszka I., Kersanté, Flavie, Walker, Matthew C, Semyanov, A., Semyanov, Alexey, Rusakov, Dmitri A., Rusakov, D. A., Herd, Murray B., Linthorst, A. C. E., Lambert, Jeremy J., Pavlov, I., Linthorst, Astrid C E, Lambert, J. J., Herd, M. B., Kersante, F., Wlodarczyk, Agnieszka I, Pavlov, Ivan, Sylantyev, Sergiy, Belelli, Delia   +27 more
core   +1 more source

Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppNL‐G‐F KI mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Whether cholinergic activity in the septohippocampal network affects cognitive dysfunction via hippocampal cholinergic neurostimulating peptide (HCNP) in Alzheimer's pathogenesis remains unclear. METHODS An Alzheimer's pathogenesis by mutation in amyloid‐beta precursor protein gene (AppNL‐G‐F) knock‐in (KI) and HCNP precursor ...
Yo Tsuda, Yuta Madokoro, Kengo Suzuki, Takuya Ooba, Toyohiro Sato, Yuto Uchida, Itsumi Nagai‐Arakawa, Takashi Saito, Hideaki Hara, Hideki Hida, Noriyuki Matsukawa   +10 more
wiley   +1 more source

A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling

Molecular Brain, 2020
The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell ...
Carlos Bas-Orth, Mirja Koch, David Lau, Bettina Buchthal, Hilmar Bading   +4 more
doaj   +1 more source

Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus. [PDF]

PLoS ONE, 2011
Neural inhibition plays an important role in auditory processing and attentional gating. Extrasynaptic GABA(A) receptors (GABA(A)R), containing α(4)and δ GABA(A)R subunits, are thought to be activated by GABA spillover outside of the synapse following ...
Ben D Richardson, Lynne L Ling, Victor V Uteshev, Donald M Caspary   +3 more
doaj   +1 more source

An iEEG investigation on sex‐specific differences in seizure duration

Epilepsia Open, Volume 11, Issue 3, Page 912-921, June 2026.
Abstract Objective Male people with epilepsy (mPWE) are at higher risk for bilateral tonic–clonic seizures (BTCs) and sudden unexpected death in epilepsy (SUDEP) compared to female people with epilepsy (fPWE). Despite major clinical and personal implications, little is known about sex‐specific differences in seizure propagation and termination ...
Paula Albert I Gracenea, Alexandra Muss, Magdalena Seethaler, Jan Rémi, Elisabeth Kaufmann   +4 more
wiley   +1 more source

Astrocytes and extracellular matrix in extrasynaptic volume transmission [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2014
Volume transmission is a form of intercellular communication that does not require synapses; it is based on the diffusion of neuroactive substances across the brain extracellular space (ECS) and their binding to extrasynaptic high-affinity receptors on neurons or glia.
Lýdia, Vargová, Eva, Syková
openaire   +2 more sources

Developmental Profiling of Structural and Functional Maturation in Mouse Corpus Callosum

Glia, Volume 74, Issue 6, June 2026.
Progressive myelin development in mouse corpus callosum is accompanied by gradual decrease in oligodendrocyte precursor cell density and increase in oligodendrocyte density. Pro‐Capase‐3 is transiently upregulated in oligodendrocyte during postnatal development.
Hayes Johnson, Maren Beall, Sophia Latifi, Juan Peng, Wenjing Sun   +4 more
wiley   +1 more source

Extrasynaptic GABAA receptors in the crosshairs of hormones and ethanol [PDF]

Neurochemistry International, 2008
Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system (CNS) it acts on two distinct types of receptor: an ion channel, i.e., an "ionotropic" receptor permeable to Cl- and HCO3- (GABAA receptors) and a G-protein coupled "metabotropic" receptor that is linked to various effector ...
openaire   +2 more sources

Behavioral Domain‐Specific Effects of Positive Modulation of α5 and α6 GABAA Receptors in a Rat Double‐Hit Stress Model

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
A double‐hit stress model in Sprague–Dawley rats induces alterations in motivation, motor impulsivity, and social recognition that are partially ameliorated by α5‐ and α6‐GABAA receptor modulation, suggesting domain‐specific effects of this modulation on the stress‐induced phenotype. ABSTRACT Impulsivity is an understudied area of post‐traumatic stress
Đorđe Đorović, Jovana Aranđelović, Jana Ivanović, Kristina Jezdić, Bojan Batinić, Dishary Sharmin, Prithu Mondal, James M. Cook, Miroslav M. Savić   +8 more
wiley   +1 more source

GABAA receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis

Frontiers in Cellular Neuroscience
GABAA receptors (γ-aminobutyric acid-gated receptors type A; GABAARs), the major structural and functional postsynaptic components of inhibitory synapses in the mammalian brain, belong to a family of GABA-gated Cl−/HCO3− ion channels.
Yusheng Sui, Martin Mortensen, Banghao Yuan, Martin W. Nicholson, Trevor G. Smart, Jasmina N. Jovanovic   +5 more
doaj   +1 more source