Results 61 to 70 of about 15,145 (185)

GABA potency at GABAA receptors found in synaptic and extrasynaptic zones

Frontiers in Cellular Neuroscience, 2012
The potency of GABA is vitally important for its primary role in activating GABAA receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often ...
Martin eMortensen, Bijal ePatel, Trevor G. Smart   +2 more
doaj   +1 more source

Balancing Extrasynaptic Excitation and Synaptic Inhibition within Olfactory Bulb Glomeruli

, 2019
Glutamatergic transmission in the brain typically occurs at well-defined synaptic connections, but increasing evidence indicates that neural excitation can also occur through activation of "extrasynaptic" glutamate receptors.
Jennifer N Bourne (12231173), Nathan E Schoppa (12231161), Joseph D Zak (12231158), David H Gire (12231170), Noah B Goodson (12231176)   +4 more
core   +1 more source

Extrasynaptic glutamate NMDA receptors: Key players in striatal function [PDF]

, 2015
N-methyl-d-aspartate receptors (NMDAR) are crucial for the function of excitatory neurotransmission and are present at the synapse and on the extrasynaptic membrane.
Garcia-Munoz, Marianela, Lopez-Huerta, Violeta G., Carrillo-Reid, Luis, Arbuthnott, Gordon W.   +3 more
core   +1 more source

The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome

Neurobiology of Disease, 2023
Evidence suggests that inhibition of α/β hydrolase-domain containing 6 (ABHD6) reduces seizures; however, the molecular mechanism of this therapeutic response remains unknown.
Ruth Westenbroek, Joshua Kaplan, Katie Viray, Nephi Stella   +3 more
doaj   +1 more source

Extrasynaptic GABA(A) Receptors: Form, Pharmacology, and Function

, 2009
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABA(A) and GABA(B) receptors. Recently, a novel form of GABA(A) receptor-mediated inhibition, termed "tonic" inhibition, has been described.
Cope, David W., Maguire, Jamie, Macdonald, Robert L.., Walker, Matthew C., Harrison, Neil L., Belelli, Delia   +5 more
core   +1 more source

Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs

, 2008
Long-term potentiation of NMDA-receptor-mediated synaptic transmission (NMDAR-LTP) is a little-understood form of plasticity. In the present study, we investigated whether NMDAR-LTP in the dentate gyrus involves recruitment of extrasynaptic NMDARs ...
HARNEY, SARAH, ANWYL, ROGER
core   +2 more sources

Presynaptic and extrasynaptic regulation of posterior nucleus of thalamus [PDF]

Journal of Neurophysiology, 2017
The posterior nucleus of thalamus (PO) is a higher-order nucleus involved in sensorimotor processing, including nociception. An important characteristic of PO is its wide range of activity profiles that vary across states of arousal, thought to underlie differences in somatosensory perception subject to attention and degree of consciousness ...
Anthony Park, Ying Li, Radi Masri, Asaf Keller   +3 more
openaire   +2 more sources

Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area

Frontiers in Neuroscience
Exposure of neurons in the brainstem mesopontine tegmental anesthesia area (MPTA) to minute quantities of GABAergic general anesthetics at clinically relevant concentrations is sufficient to induce loss-of-consciousness (LOC), while lesioning this ...
Angham Ibraheem, Kristina Vaso, Anne Minert, Shai-Lee Yatziv, Mark Baron, Marshall Devor, Marshall Devor   +6 more
doaj   +1 more source

BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A

Cell Reports, 2015
The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors.
David Lau, C. Peter Bengtson, Bettina Buchthal, Hilmar Bading   +3 more
doaj   +1 more source

Extrasynaptic localization of GABA in the developing mouse cerebellum [PDF]

Neuroscience Research, 2004
In the adult brain, gamma-amino butyric acid (GABA) is synaptically released and mediates inhibitory transmission. Recent studies have revealed that GABA is a trophic factor for brain development. To reveal the distribution of GABA and its secretion mechanisms during brain development, we investigated the immunohistochemical localization of two ...
Takayama, Chitoshi, Inoue, Yoshiro
openaire   +4 more sources