Results 61 to 70 of about 12,399 (169)
British Journal of Pharmacology, Volume 183, Issue 16, Page 4939-4952, August 2026.Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi +13 more
wiley +1 more source
Extrasynaptic localization of GABA in the developing mouse cerebellum [PDF]
Neuroscience Research, 2004 In the adult brain, gamma-amino butyric acid (GABA) is synaptically released and mediates inhibitory transmission. Recent studies have revealed that GABA is a trophic factor for brain development. To reveal the distribution of GABA and its secretion mechanisms during brain development, we investigated the immunohistochemical localization of two ...
Takayama, Chitoshi, Inoue, Yoshiro
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Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, Volume 13, Issue 37, 3 July 2026.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
The Contribution of Extrasynaptic Signaling to Cerebellar Information Processing [PDF]
The Cerebellum, 2014 The diversity of synapses within the simple modular structure of the cerebellum has been crucial for study of the phasic extrasynaptic signaling by fast neurotransmitters collectively referred to as "spillover." Additionally, the accessibility of cerebellar components for in vivo recordings and their recruitment by simple behaviors or sensory stimuli ...
Luke T, Coddington +2 more
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A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling
Molecular Brain, 2020 The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell ...
Carlos Bas-Orth +4 more
doaj +1 more source
Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus. [PDF]
PLoS ONE, 2011 Neural inhibition plays an important role in auditory processing and attentional gating. Extrasynaptic GABA(A) receptors (GABA(A)R), containing α(4)and δ GABA(A)R subunits, are thought to be activated by GABA spillover outside of the synapse following ...
Ben D Richardson +3 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract Alzheimer's disease (AD) is a neurodegenerative condition marked by cognitive decline and synaptic issues. Recent studies show primary cilia (PCs), sensory organelles present on the surface of most mammalian cells, act as a critical regulators of brain homeostasis and signaling.
Vishal Singh Guleria +1 more
wiley +1 more source
Astrocytes and extracellular matrix in extrasynaptic volume transmission [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Volume transmission is a form of intercellular communication that does not require synapses; it is based on the diffusion of neuroactive substances across the brain extracellular space (ECS) and their binding to extrasynaptic high-affinity receptors on neurons or glia.
Lýdia, Vargová, Eva, Syková
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Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.The monocyclic sesquiterpene α‐humulene elicited a significant anxiolytic‐like behavior in adult zebrafish and no observable acute toxicity. Pharmacological dissection suggested that this effect is independent of the benzodiazepine (BZD) binding site on the gamma‐aminobutyric acid (GABA) type A receptor (GABAAR), but it depends on the serotonin type 3 ...
Alex de Souza Borges +9 more
wiley +1 more source
Extrasynaptic GABAA receptors in the crosshairs of hormones and ethanol [PDF]
Neurochemistry International, 2008 Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system (CNS) it acts on two distinct types of receptor: an ion channel, i.e., an "ionotropic" receptor permeable to Cl- and HCO3- (GABAA receptors) and a G-protein coupled "metabotropic" receptor that is linked to various effector ...
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