Results 61 to 70 of about 14,388 (200)

Thermodynamic Efficiency of Somatic Exocytosis of Serotonin

Frontiers in Physiology, 2019
Through somatic exocytosis neurons liberate immense amounts of transmitter molecules that modulate the functioning of the nervous system. A stream of action potentials triggers an ATP-dependent transport of transmitter-containing vesicles to the plasma ...
Paula Noguez, J. Miguel Rubí, Francisco F. De-Miguel   +2 more
doaj   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.

, 2012
N-methyl-D-aspartate receptors (NMDARs) are located in neuronal cell membranes at synaptic and extrasynaptic locations, where they are believed to mediate distinct physiological and pathological processes.
Papouin, Thomas, Mothet, J. P., Ruel, Jérôme, Ladépêche, L., POLLEGIONI, LOREDANO, SACCHI, SILVIA, Hanini, Marwa, Hanini, M., Ladépêche, Laurent, Labasque, M., Oliet, S. H., Labasque, Marilyne, Oliet, Stéphane H.R., Groc, Laurent, Mothet, Jean-Pierre, Ruel, J., Groc, L., Papouin, T.   +17 more
core   +2 more sources

Extrasynaptic localization of GABA in the developing mouse cerebellum [PDF]

Neuroscience Research, 2004
In the adult brain, gamma-amino butyric acid (GABA) is synaptically released and mediates inhibitory transmission. Recent studies have revealed that GABA is a trophic factor for brain development. To reveal the distribution of GABA and its secretion mechanisms during brain development, we investigated the immunohistochemical localization of two ...
Takayama, Chitoshi, Inoue, Yoshiro
openaire   +3 more sources

Extrasynaptic NMDA Receptors : Mediators of Excitotoxic Cell Death [PDF]

, 2004
The N-methyl-D-aspartate (NMDA) type of glutamate receptor is a calcium-permeable ion channel with important functions in the physiology and pathology of the mammalian brain.
Wittmann, Malte, Bading, Hilmar, Bengtson, C. Peter   +2 more
core   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

The Contribution of Extrasynaptic Signaling to Cerebellar Information Processing [PDF]

The Cerebellum, 2014
The diversity of synapses within the simple modular structure of the cerebellum has been crucial for study of the phasic extrasynaptic signaling by fast neurotransmitters collectively referred to as "spillover." Additionally, the accessibility of cerebellar components for in vivo recordings and their recruitment by simple behaviors or sensory stimuli ...
Luke T, Coddington, Angela K, Nietz, Jacques I, Wadiche   +2 more
openaire   +2 more sources

Balancing Extrasynaptic Excitation and Synaptic Inhibition within Olfactory Bulb Glomeruli

, 2019
Glutamatergic transmission in the brain typically occurs at well-defined synaptic connections, but increasing evidence indicates that neural excitation can also occur through activation of "extrasynaptic" glutamate receptors.
Jennifer N Bourne (12231173), Nathan E Schoppa (12231161), Joseph D Zak (12231158), David H Gire (12231170), Noah B Goodson (12231176)   +4 more
core   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Extrasynaptic GABA(A) Receptors: Form, Pharmacology, and Function

, 2009
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABA(A) and GABA(B) receptors. Recently, a novel form of GABA(A) receptor-mediated inhibition, termed "tonic" inhibition, has been described.
Cope, David W., Maguire, Jamie, Macdonald, Robert L.., Walker, Matthew C., Harrison, Neil L., Belelli, Delia   +5 more
core   +1 more source