Results 31 to 40 of about 21,092 (247)

Anaphylactic Degranulation of Mast Cells: Focus on Compound Exocytosis

Journal of Immunology Research, 2019
Anaphylaxis is a notorious type 2 immune response which may result in a systemic response and lead to death. A precondition for the unfolding of the anaphylactic shock is the secretion of inflammatory mediators from mast cells in response to an allergen,
Ofir Klein, Ronit Sagi-Eisenberg
doaj   +1 more source

The dynamics of somatic exocytosis in monoaminergic neurons

Frontiers in Physiology, 2012
Some monoaminergic neurons can release neurotransmitters by exocytosis from their cell bodies. The amount of monoamine released by somatic exocytosis can be comparable to that released by synaptic exocytosis, though neither the underlying mechanisms nor ...
Bidyut eSarkar, Anand Kant Das, Senthil eArumugam, Sanjeev Kumar Kaushalya, Arkarup eBandyopadhyay, Jayaprakash eBalaji, Sudipta eMaiti   +6 more
doaj   +1 more source

Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]

, 2012
Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Weiping Lu (120665), Dun, Alison R., Lu, Weiping, Rory R. Duncan (120667), Weiping Lu, Gabriel J. Lord (120664), Colin Rickman (120669), Andrew Dunn, Gabriel J Lord, Martin, Kirsty J, Lei Yang (102719), Qiu, Zhen, Rickman, Colin; id_orcid, Kirsty J Martin, Lei Yang, Duncan, Rory R, Duncan, Rory R., Alison R. Dun (120660), Zhen Qiu (120662), Rickman, Colin, Dun, Alison, Qiu, Zhen; id_orcid, Colin Rickman, Rory R Duncan, Lord, Gabriel J, Kirsty J. Martin (120661), Alison R Dun, Lord, Gabriel J., Yang, Lei, Martin, Kirsty J., Andrew Dunn (120663), Dunn, Andrew, Zhen Qiu   +32 more
core   +1 more source

Network-based insights into miRNA regulation of β-cell insulin secretion in type 2 diabetes

iScience
Summary: Increasing evidence suggests that microRNAs (miRNAs) contribute to pancreatic β-cell compensation during type 2 diabetes (T2D) pathogenesis. To examine miRNA-mRNA interactions in human islets and their roles in β-cell insulin secretion and T2D ...
Elaine Cowan, Alexandros Karagiannopoulos, Alessio Pollastri, Akira Asai, Mototsugu Nagao, Marlena Maziarz, Jonathan L.S. Esguerra, Lena Eliasson   +7 more
doaj   +1 more source

Further Characterization of Dopamine Release by Permeabilized PC 12 Cells [PDF]

, 1987
Rat pheochromocytoma cells (PC 12) permeabilized with staphylococcal α-toxin release [3H]dopamine after addition of micromolar Ca2+. This does not require additional Mg2+-ATP (in contrast to bovine adrenal medullary chromaffin cells).
Ahnert-Hilger, G., Manfred Gratzl, Gratzl, Manfred, Gudrun Ahnert‐Hilger   +3 more
core   +1 more source

Molecular and physiological regulation of adiponectin exocytosis in white adipocytes [PDF]

, 2015
In this thesis we have investigated the mechanisms of white adipocyte regulated exocytosis in health and disease, with a special focus on adiponectin. We have applied a combination of electrophysiological membrane capacitance measurements, biochemical ...
Komai, Ali
core   +1 more source

Introduction of Macromolecules into Bovine Adrenal Medullary Chromaffin Cells and Rat Pheochromocytoma Cells (PC12) by Permeabilization with Streptolysin O: Inhibitory Effect of Tetanus Toxin on Catecholamine Secretion [PDF]

, 1989
Conditions are described for controlled plasma membrane permeabilization of rat pheochromocytoma cells (PC12) and cultured bovine adrenal chromaffin cells by Streptolysin O (SLO).
Ahnert-Hilger, G., Gratzl, Manfred, Bader, M. F., Bhakdi, S.   +3 more
core   +1 more source

Voltage-Dependent Calcium Channels at the Plasma Membrane, but Not Vesicular Channels, Couple Exocytosis to Endocytosis

Cell Reports, 2012
Although calcium influx triggers endocytosis at many synapses and non-neuronal secretory cells, the identity of the calcium channel is unclear. The plasma membrane voltage-dependent calcium channel (VDCC) is a candidate, and it was recently proposed that
Lei Xue, Zhen Zhang, Benjamin D. McNeil, Fujun Luo, Xin-Sheng Wu, Jiansong Sheng, Wonchul Shin, Ling-Gang Wu   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.

PLoS ONE, 2014
Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca2+-dependent insulin exocytosis with respect to pool depletion and Ca2+-current inactivation.
Morten Gram Pedersen, Vishal Ashok Salunkhe, Emma Svedin, Anna Edlund, Lena Eliasson   +4 more
doaj   +1 more source