Results 31 to 40 of about 76,537 (156)

Anaphylactic Degranulation of Mast Cells: Focus on Compound Exocytosis

Journal of Immunology Research, 2019
Anaphylaxis is a notorious type 2 immune response which may result in a systemic response and lead to death. A precondition for the unfolding of the anaphylactic shock is the secretion of inflammatory mediators from mast cells in response to an allergen,
Ofir Klein, Ronit Sagi-Eisenberg
doaj   +1 more source

A Novel Role of the TRPM4 Ion Channel in Exocytosis

Cells, 2022
Under physiological conditions, the widely expressed calcium-activated TRPM4 channel conducts sodium into cells. This sodium influx depolarizes the plasma membrane and reduces the driving force for calcium entry.
Paulina Stokłosa, Sven Kappel, Christine Peinelt   +2 more
doaj   +1 more source

The dynamics of somatic exocytosis in monoaminergic neurons

Frontiers in Physiology, 2012
Some monoaminergic neurons can release neurotransmitters by exocytosis from their cell bodies. The amount of monoamine released by somatic exocytosis can be comparable to that released by synaptic exocytosis, though neither the underlying mechanisms nor ...
Bidyut eSarkar, Anand Kant Das, Senthil eArumugam, Sanjeev Kumar Kaushalya, Arkarup eBandyopadhyay, Jayaprakash eBalaji, Sudipta eMaiti   +6 more
doaj   +1 more source

Network-based insights into miRNA regulation of β-cell insulin secretion in type 2 diabetes

iScience
Summary: Increasing evidence suggests that microRNAs (miRNAs) contribute to pancreatic β-cell compensation during type 2 diabetes (T2D) pathogenesis. To examine miRNA-mRNA interactions in human islets and their roles in β-cell insulin secretion and T2D ...
Elaine Cowan, Alexandros Karagiannopoulos, Alessio Pollastri, Akira Asai, Mototsugu Nagao, Marlena Maziarz, Jonathan L.S. Esguerra, Lena Eliasson   +7 more
doaj   +1 more source

Voltage-Dependent Calcium Channels at the Plasma Membrane, but Not Vesicular Channels, Couple Exocytosis to Endocytosis

Cell Reports, 2012
Although calcium influx triggers endocytosis at many synapses and non-neuronal secretory cells, the identity of the calcium channel is unclear. The plasma membrane voltage-dependent calcium channel (VDCC) is a candidate, and it was recently proposed that
Lei Xue, Zhen Zhang, Benjamin D. McNeil, Fujun Luo, Xin-Sheng Wu, Jiansong Sheng, Wonchul Shin, Ling-Gang Wu   +7 more
doaj   +1 more source

Imaging the rapid yet transient accumulation of regulatory lipids, lipid kinases, and protein kinases during membrane fusion, at sites of exocytosis of MMP-9 in MCF-7 cells

Lipids in Health and Disease, 2020
Background The regulation of exocytosis is physiologically vital in cells and requires a variety of distinct proteins and lipids that facilitate efficient, fast, and timely release of secretory vesicle cargo.
Dominique C. Stephens, Tyrel W. Powell, Justin W. Taraska, Dinari A. Harris   +3 more
doaj   +1 more source

G-Protein Coupled Receptor-Evoked Glutamate Exocytosis from Astrocytes: Role of Prostaglandins

Neural Plasticity, 2014
Astrocytes are highly secretory cells, participating in rapid brain communication by releasing glutamate. Recent evidences have suggested that this process is largely mediated by Ca2+-dependent regulated exocytosis of VGLUT-positive vesicles.
Corrado Cali, Jan Lopatar, Francesco Petrelli, Luca Pucci, Paola Bezzi   +4 more
doaj   +1 more source

Effects of Perfluorocarbons on surfactant exocytosis and membrane properties in isolated alveolar type II cells

Respiratory Research, 2010
Background Perfluorocarbons (PFC) are used to improve gas exchange in diseased lungs. PFC have been shown to affect various cell types. Thus, effects on alveolar type II (ATII) cells and surfactant metabolism can be expected, data, however, are ...
Ravasio Andrea, Hobi Nina, Hackspiel Irmgard, Wemhöner Andreas, Haller Thomas, Rüdiger Mario   +5 more
doaj   +1 more source

SIP30 involvement in vesicle exocytosis from PC12 cells

Biochemistry and Biophysics Reports
SNAP25 (synaptosome-associated protein of 25 kDa) is a core SNARE (soluble N-ethylmaleimide-sensitive factor attachment receptor) protein; and the interaction between SNAP25 and other SNARE proteins is essential for synaptic vesicle exocytosis ...
Ning Guo, Lei Yu
doaj   +1 more source

Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo

Biology Open, 2012
Summary The abundant proteoglycan, aggrecan, is resorbed from growth plate cartilage during endochondral bone ossification, yet mice with genetically-ablated aggrecan-degrading activity have no defects in bone formation.
Edward R. Bastow, Karena Last, Sue Golub, Jennifer L. Stow, Amanda C. Stanley, Amanda J. Fosang   +5 more
doaj   +1 more source