Results 51 to 60 of about 151,391 (333)

Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction

eLife
Neuropeptides and neurotrophins are stored in and released from dense core vesicles (DCVs). While DCVs and synaptic vesicles (SVs) share fundamental SNARE/SM proteins for exocytosis, a detailed understanding of DCV exocytosis remains elusive. We recently
Adlin Abramian, Rein I Hoogstraaten, Fiona H Murphy, Kathryn F McDaniel, Ruud F Toonen, Matthijs Verhage   +5 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Tracing the STING exocytosis pathway during herpes viruses infection

mBio
The STimulator of INterferon Genes (STING) constitutes a major DNA-sensing pathway that restricts HSV-1 infection in different models by activating type I interferon and pro-inflammatory responses.
Christos Dogrammatzis, Rabina Saud, Hope Waisner, Sarah Lasnier, Sreenath Muraleedharan Suma, Brandon Grieshaber, Maria Kalamvoki   +6 more
doaj   +1 more source

36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

Clinical Epigenetics, 2017
Background Subjects born with low birth weight (LBW) display a more energy-conserving response to fasting compared with normal birth weight (NBW) subjects.
Line Hjort, Sine W. Jørgensen, Linn Gillberg, Elin Hall, Charlotte Brøns, Jan Frystyk, Allan A. Vaag, Charlotte Ling   +7 more
doaj   +1 more source

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, EarlyView.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

Structure Formation in Butterfly Scales: Interplay of Genetic Control, Mechanical Instabilities, and Dynamic Material Properties

Advanced Functional Materials, EarlyView.
Butterfly wing scales are intricate cuticular functional nanosctructures. This perspective suggests that spatially varying material properties, cytoskeletal constraints, and growth‐driven mechanical instabilities shape the resulting nanoscale architectures created from single cells.
Anupama Prakash, Victoria Lloyd, Yi Yang, Anna‐Lee Jessop, Anthony McDougal, Primož Pirih, Guillaume Duclos, Andrew Parnell, Mathias Kolle, Nicola J. Nadeau, Bodo D. Wilts   +10 more
wiley   +1 more source

tPA‐GFP is a reliable probe for detecting compound exocytosis in human pancreatic β‐cells

FASEB BioAdvances
Pancreatic β‐cells secrete insulin stored in large dense core vesicles (LDCV) by fusion of vesicle and plasma membrane during a process called insulin exocytosis.
Aishwarya A. Makam, Shruti Sharma, Prajwal Nagle, Nandhini M. Sundaram, Vidya Mangala Prasad, Nikhil R. Gandasi   +5 more
doaj   +1 more source

Minimal requirements for exocytosis [PDF]

, 1985
The membrane-permeabilizing effects of streptolysin O, staphylococcal alpha-toxin, and digitonin on cultured rat pheochromocytoma cells were studied. All three agents perturbed the plasma membrane, causing release of intracellular 86Rb+ and uptake of ...
Ahnert-Hilger, G., Bhakdi, S., Gratzl, Manfred   +2 more
core  

All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters [PDF]

, 2016
We report on the ion beam fabrication of all-carbon multi electrode arrays (MEAs) based on 16 graphitic micro-channels embedded in single-crystal diamond (SCD) substrates.
Battiato, A., Bernardi, E., Carabelli, V., Carbone, E., Franchino, C., Gosso, S., Olivero, P., Pasquarelli, A., Picollo, F., Plaitano, M.   +9 more
core   +2 more sources