Results 31 to 40 of about 1,253,804 (210)

Integrating multiple aspects of mitochondrial dynamics in neurons: Age-related differences and dynamic changes in a chronic rotenone model

Neurobiology of Disease, 2011
Changes in dynamic properties of mitochondria are increasingly implicated in neurodegenerative diseases, particularly Parkinson's disease (PD). Static changes in mitochondrial morphology, often under acutely toxic conditions, are commonly utilized as ...
Beth Arnold, Steven J. Cassady, Victor S. VanLaar, Sarah B. Berman   +3 more
doaj   +1 more source

Mitochondrial fusion protein: a new therapeutic target for lung injury diseases

Frontiers in Physiology
Mitochondria are essential organelles responsible for cellular energy supply. The maintenance of mitochondrial structure and function relies heavily on quality control systems, including biogenesis, fission, and fusion. Mitochondrial fusion refers to the
Guiyang Jia, Erqin Song, Qianxia Huang, Miao Chen, Guoyue Liu   +4 more
doaj   +1 more source

Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus

Neurology Research International, 2015
Brain is predominantly susceptible to oxidative stress and mitochondrial dysfunction during hypobaric hypoxia, and therefore undergoes neurodegeneration due to energy crisis.
Khushbu Jain, Dipti Prasad, Shashi Bala Singh, Ekta Kohli   +3 more
doaj   +1 more source

Role of mitochondrial fusion in doxorubicin-induced cardiotoxicity [PDF]

Jichu yixue yu linchuang
Adriamycin is a widely used anti-tumor drug. Targeting mitochondrial fusion proteins/mitofusion 1/2(MFN1/2) and nuclear factor-erythroid 2-related factor 2(NRF2) can up-regulate the expression of mitochondrial fusion protein through PKCε/Stat3/MFN2 ...
WANG Yuqi, WANG Xinyu, LUO Haowen, LU Zhaoxin, ZHAO Yiwei, CHANG Pan
doaj   +1 more source

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration [PDF]

, 2009
Background Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive ...
Rüb Udo, Jendrach, M., Wenzel, Dirk, Auburger Georg, Miguel Barrera, Nussbaum, Robert L, Leuner, K., Hoepken, Hans Hermann, Amy Chen, Kudin, Alexei P, Auburger, Georg, Mekhman Azizov, Zimmermann, Annabelle, Zimmerman, Annabelle, Fernández-Ruiz, Javier, Dorothea Becker, Nussbaum, R., Becker, D., Auburger, G., Gispert, Suzana, Zimmermann Annabelle, Hoepken, Hans-Hermann, Nussbaum, Robert L., Robert L Nussbaum, Hoepken, H., Müller Walter E., Leslie Huber, Müller, Walter E., Gispert Suzana, García-Arencíbia, Moisés, Roeper Jochen, Ricciardi Filomena, Jendrach Marina, Dirk Wenzel, Kurz, A., Kurz Alexander, Voos, W., Azizov Mekhman, Kunz Wolfram S., Kurz, Alexander, Jendrach, Marina, Jochen Roeper, Müller, W., Wenzel, D., Rohrer, Hermann, Gispert, S., Hoepken Hans-Hermann, Azizov, M., Andreas S Reichert, Udo Rüb, Voos, Wolfgang, Reichert, Andreas S., Kristina Leuner, Rohrer, H., Kunz, Wolfram S, Javier Fernández-Ruiz, Barrera Miguel, Rüb, Udo, Wenzel Dirk, Chen Amy, Becker Dorothea, Rüb, U., Marina Jendrach, Müller, Walter E, Chen, A., Barrera, Miguel, Moisés García-Arencíbia, Fernández-Ruiz Javier, Wolfram S Kunz, Kudin, Alexei P., Reichert, A., Annabelle Zimmermann, Fernández-Ruiz, J., Kunz, W., Leuner Kristina, Rohrer Hermann, Alexander Kurz, Reichert Andreas S., Alexei P Kudin, Hermann Rohrer, Azizov, Mekhman, Reichert, Andreas, Zimmermann, A., Walter E Müller, Barrera, M., García-Arencíbia Moisés, Nussbaum Robert L., Roeper, Jochen, Chen, Amy, Filomena Ricciardi, Hans-Hermann Hoepken, Kudin Alexei P., Huber, L., Suzana Gispert, García-Arencíbia, M., Becker, Dorothea, Reichert, Andreas S, Georg Auburger, Huber Leslie, Ricciardi, Filomena, Ricciardi, F., Kunz, Wolfram S., Kudin, A., Leuner, Kristina, Roeper, J., Wolfgang Voos, Voos Wolfgang, Huber, Leslie   +107 more
core   +1 more source

Mitofusin-Mediated Mitochondrial Fusion Inhibits Pseudorabies Virus Infection in Porcine Cells

Veterinary Sciences
Background: Mitochondria are highly dynamic organelles that undergo fusion/fission dynamics, and emerging evidence has established that mitochondrial dynamics plays a crucial regulatory role in the process of viral infection.
Xiuhan Xu, Yuan Zhao, Zhenbang Zhu, Wei Wen, Xiangdong Li   +4 more
doaj   +1 more source

The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury

Biomolecules, 2021
Emerging evidence shows that mitochondria fusion/fission imbalance is related to the occurrence of hyperglycemia-induced vascular injury. To study the temporal dynamics of mitochondrial fusion and fission, we observed the alteration of mitochondrial ...
Yunsi Zheng, Anqi Luo, Xiaoquan Liu
doaj   +1 more source

Mechanisms of hepatocellular toxicity associated with dronedarone and other mitochondrial toxicants [PDF]

, 2014
Idiosyncratic drug-induced liver injury is a rare toxic event that typically occurs at therapeutic doses, which are generally safe to the majority of patients.
Felser, Andrea Debora
core   +1 more source

Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor. [PDF]

, 2013
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Maddock Helen, Hussain, Afthab, Gharanei Mayel, Maddock, H, Janneh, Omar, Omar Janneh, Maddock, Helen L., Helen Maddock, Hussain, A, Gharanei, M., Hussain Afthab, Afthab Hussain, Janneh, O, Mayel Gharanei, Janneh Omar, Gharanei, M   +15 more
core   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source