Results 1 to 10 of about 14,571 (197)
The Role of Impaired Mitochondrial Dynamics in MFN2-Mediated Pathology
Frontiers in Cell and Developmental Biology, 2022 The Mitofusin 2 protein (MFN2), encoded by the MFN2 gene, was first described for its role in mediating mitochondrial fusion. However, MFN2 is now recognized to play additional roles in mitochondrial autophagy (mitophagy), mitochondrial motility, lipid ...
Timothy E Shutt, Shutt Timothy E
exaly +8 more sources
Cell Reports, 2023 Summary: Mitochondrial morphology is regulated by the post-translational modifications of the dynamin family GTPase proteins including mitofusin 1 (MFN1), MFN2, and dynamin-related protein 1 (DRP1).
Christopher M Yip, G Angus Mcquibban
exaly +3 more sources
Frontiers in Molecular Neuroscience, 2021 Charcot-Marie-Tooth (CMT) disease is one of the most common genetically inherited neurological disorders and CMT type 2A (CMT 2A) is caused by dominant mutations in the mitofusin-2 (MFN2) gene. MFN2 is located in the outer mitochondrial membrane and is a
Yongchao Mou, Xue-Jun Li, Chen Zhenyu
exaly +3 more sources
Redox Biology, 2022 Imbalanced mitochondrial dynamics including inhibited mitochondrial fusion is associated with cardiac dysfunction as well as tumorigenesis. This study sought to explore the effects of promoting mitochondrial fusion on doxorubicin(Dox)-induced ...
Mingge Ding +2 more
exaly +3 more sources
RIPK3-driven phosphorylation of MFN2 orchestrates endoplasmic reticulum-mitochondria interaction and cardiomyocyte stress responses [PDF]
Redox BiologyBackground: Recent studies have demonstrated that necroptosis is one of the main forms of cardiomyocyte death in heart diseases. However, the crosstalk between the death-receptor necroptosis pathway and the mitochondrial necroptosis pathway remains ...
Yu Wang +9 more
doaj +2 more sources
Mfn2 regulates mitochondria-associated ER membranes to affect PCOS oocyte development
Endocrine Connections, 2023 This study aimed to investigate the role of mitochondrial-related protein Mfn2 in polycystic ovary syndrome (PCOS) and its impact on oocyte development.
Xiuhua Liao +7 more
doaj +1 more source
Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity
Frontiers in Bioscience-Landmark, 2022 Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China.
Jinling Wang +6 more
doaj +1 more source
A human mitofusin 2 mutation can cause mitophagic cardiomyopathy
eLife, 2023 Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15–20× over-represented in
Antonietta Franco +12 more
doaj +1 more source
Involvement of Mfn2, Bcl2/Bax signaling and mitochondrial viability in the potential protective effect of Royal jelly against mitochondria-mediated ovarian apoptosis by cisplatin in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): The current study aimed to assess cisplatin-mediated ovarian apoptosis in a rat model by Royal jelly (RJ). Materials and Methods: Thirty female adult albino rats (180-200 g) were divided into three groups (n=10): saline (0.9% NaCl, IP) was ...
khalid Hashem +3 more
doaj +1 more source
Stem Cell Research & Therapy, 2021 Background Sepsis is a major cause of death in ICU, and intestinal barrier dysfunction is its important complication, while the treatment is limited. Recently, mesenchymal stem cell-derived microvesicles (MMVs) attract much attention as a strategy of ...
Danyang Zheng +7 more
doaj +1 more source