The role of Mitofusin-1 and Mitofusin-2 in periodontal disease: a comprehensive review [PDF]
Frontiers in Oral HealthPeriodontal disease is a widespread chronic inflammatory state influencing the supporting anatomy of the teeth, distinguished by oxidative stress, progressive bone loss, and tissue damage.
Sudhir Rama Varma, Asok Mathew
exaly +4 more sources
Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity [PDF]
Virulence, 2021 Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli.
In Soo Kim +2 more
exaly +3 more sources
Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. [PDF]
PLoS ONE, 2016 Charcot-Marie-Tooth disease type 2A (CMT2A), the most common axonal form of hereditary sensory motor neuropathy, is caused by mutations of mitofusin-2 (MFN2). Mitofusin-2 is a GTPase required for fusion of mitochondrial outer membranes, repair of damaged
Peter Bannerman +4 more
doaj +11 more sources
A human mitofusin 2 mutation can cause mitophagic cardiomyopathy [PDF]
eLife, 2023 Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15–20× over-represented in
Antonietta Franco +12 more
doaj +2 more sources
Mitofusin 2 displays fusion-independent roles in proteostasis surveillance [PDF]
Nature CommunicationsMitochondria are essential organelles and their functional state dictates cellular proteostasis. However, little is known about the molecular gatekeepers involved, especially in absence of external stress.
Mariana Joaquim +18 more
doaj +2 more sources
Mitochonic acid 5 regulates mitofusin 2 to protect microglia [PDF]
Neural Regeneration Research, 2021 Microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis.
Jian Tan +7 more
doaj +2 more sources
Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation [PDF]
Cells, 2022 Inter-organellar communication is emerging as one of the most crucial regulators of cellular physiology. One of the key regulators of inter-organellar communication is Mitofusin-2 (MFN2).
Jyoti Tanwar +12 more
doaj +2 more sources
Mitofusin 2 is required for preventing deoxynivalenol-induced porcine intestinal epithelial cell damage [PDF]
Journal of Animal Science and BiotechnologyBackgrounds Deoxynivalenol (DON) is an abundant environmental pollutant in feed, posing serious health hazards to animals. However, whether DON triggers an imbalance in mitochondrial fission/fusion and the underlying mechanisms involved remain poorly ...
Kan Xiao +9 more
doaj +2 more sources
Life Science Alliance, 2023 Our analysis of a CMT2A-associated mitofusin variant reveals that aberrant mitochondrial tethering results in perinuclear clusters and that conformational dynamics in Hinge 2 are required to progress from membrane tethering to membrane fusion.
Stephanie R Sloat, Suzanne Hoppins
doaj +1 more source
Adropin Alleviates Myocardial Fibrosis in Diabetic Cardiomyopathy Rats: A Preliminary Study
Frontiers in Cardiovascular Medicine, 2021 Aim: Adropin (ADR) is a novel regulatory polypeptide and has important effects on energy metabolism in the heart. However, it is still unclear whether ADR can relieve ventricular remodeling in DCM. Therefore, this study was conducted to assess the effect
Mao Liu +5 more
doaj +1 more source