Results 31 to 40 of about 24,584,287 (168)
Role of mitofusin 2 in the renal stress response. [PDF]
PLoS ONE, 2012 The role of mitofusin 2 (MFN2), a key regulator of mitochondrial morphology and function in the renal stress response is unknown. To assess its role, the MFN2 floxed gene was conditionally deleted in the kidney of mice (MFN2 cKO) by Pax2 promoter driven ...
Jonathan M Gall +8 more
doaj +1 more source
The role of ultrasound and mitofusin-2 levels to predict pregnancy outcomes in patients with severe preeclampsia: a case-control study. [PDF]
Rev Assoc Med Bras (1992)OBJECTIVE: The aim of this study was to evaluate mitofusin-2 levels and fetal Doppler ultrasonography effects in patients with severe preeclampsia. METHODS: This single-center case-control study was conducted in the gynecology service of the university ...
Uçkan K +5 more
europepmc +2 more sources
Cancer: Untethering Mitochondria from the Endoplasmic Reticulum?
Frontiers in Oncology, 2017 Following the discovery of the mitochondria-associated membrane (MAM) as a hub for lipid metabolism in 1990 and its description as one of the first examples for membrane contact sites at the turn of the century, the past decade has seen the emergence of ...
Maria Sol Herrera-Cruz, Thomas Simmen
doaj +1 more source
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages
Frontiers in Immunology, 2021 Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria.
Vera Khodzhaeva +9 more
doaj +1 more source
, 2021 Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small molecule mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach.
Sidney B. Williams (11306623) +7 more
core +4 more sources
Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled. [PDF]
Signal Transduct Target TherFranchino CA, Motori E, Bergami M.
europepmc +2 more sources
Mitofusin 2: from functions to disease [PDF]
, 2018 Mitochondria are highly dynamic organelles whose functions are essential for cell viability. Within the cell, the mitochondrial network is continuously remodeled through the balance between fusion and fission events.
Filadi, Riccardo +5 more
core +1 more source
eLife, 2014 Mitochondrial fusion and fission affect the distribution and quality control of mitochondria. We show that Marf (Mitochondrial associated regulatory factor), is required for mitochondrial fusion and transport in long axons.
Hector Sandoval +14 more
doaj +1 more source
Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts [PDF]
, 2022 Dominant mutations in ubiquitously expressed Mitofusin 2 gene (MFN2) cause Charcot-Marie-Tooth type 2A (CMT2A; OMIM 609260), an inherited sensory-motor neuropathy that affects peripheral nerve axons.
Doccini, Stefano +12 more
core +1 more source
Back to The Fusion: Mitofusin-2 in Alzheimer's Disease [PDF]
, 2020 Mitochondria are dynamic organelles that undergo constant fission and fusion. Mitochondria dysfunction underlies several human disorders, including Alzheimer's disease (AD).
Agnese Graziosi +7 more
core +3 more sources