Results 51 to 60 of about 24,584,287 (168)
Infectious Agents and Cancer, 2018 Objective To investigate the expression of Mitofusin-2 (MFN2) in HCC tissues and its role in the development of HCC. Methods A total of 107 HCC specimens were collected for tissue microarray analysis and immunohistochemistry (IHC) analysis.
Xiumei Wang +7 more
doaj +1 more source
Advanced Science, EarlyView.ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang +5 more
wiley +1 more source
Mitofusin 2: A link between mitochondrial function and substrate metabolism?
, 2021 Mitochondria are dynamic, interactive organelles that connect cellular signaling and whole-cell homeostasis. This "mitochatting" allows the cell to receive information about the mitochondria's condition before accommodating energy demands.
Ortiz, Rudy M, Emery, Janna M
core +1 more source
ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites
Advanced Science, EarlyView.ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng +9 more
wiley +1 more source
, 2012 Mitochondria play central roles in integrating pro- and antiapoptotic stimuli, and JNK is well known to have roles in activating apoptotic pathways. We establish a critical link between stress-induced JNK activation, mitofusin 2, which is an essential ...
Leboucher, Guillaume P. +7 more
core +1 more source
Mitofusin 1 and Mitofusin 2 Function in the Context of Brain Development
, 2011 Mitofusin 1 and 2 are outer-mitochondrial membrane proteins that have been shown to be involved in fusion. Mitofusin 2 has also been associated with apoptosis and development.
Hamze, Carmen
core +2 more sources
CMT2A harboring mitofusin 2 mutation with optic nerve atrophy and normal visual acuity [PDF]
, 2020 Charcot-Marie-Tooth (CMT) constitutes a group of heterogeneous hereditary motor and sensor neuropathies. Mutations in mitofusin-2 (MFN2) cause CMT type 2A by altering mitochondrial fusion and trafficking along with the axonal microtubule system.
D'oria F. +6 more
core +1 more source
Mitofusin 2-deficiency suppresses cell proliferation through disturbance of autophagy. [PDF]
PLoS ONE, 2015 Mitofusin2 (Mfn2), a mitochondrial outer membrane protein serving primarily as a mitochondrial fusion protein, has multiple functions in regulating cell biological processes. Defects of Mfn2 were found in diabetes, obesity, and neurodegenerative diseases.
Yanhong Ding +4 more
doaj +1 more source
Advanced Science, EarlyView.This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su +9 more
wiley +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source