Results 51 to 60 of about 17,663,383 (215)
Cancer: Untethering Mitochondria from the Endoplasmic Reticulum?
Frontiers in Oncology, 2017 Following the discovery of the mitochondria-associated membrane (MAM) as a hub for lipid metabolism in 1990 and its description as one of the first examples for membrane contact sites at the turn of the century, the past decade has seen the emergence of ...
Maria Sol Herrera-Cruz, Thomas Simmen
doaj +1 more source
eLife, 2014 Mitochondrial fusion and fission affect the distribution and quality control of mitochondria. We show that Marf (Mitochondrial associated regulatory factor), is required for mitochondrial fusion and transport in long axons.
Hector Sandoval +14 more
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Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. [PDF]
PLoS ONE, 2016 Charcot-Marie-Tooth disease type 2A (CMT2A), the most common axonal form of hereditary sensory motor neuropathy, is caused by mutations of mitofusin-2 (MFN2). Mitofusin-2 is a GTPase required for fusion of mitochondrial outer membranes, repair of damaged
Peter Bannerman +4 more
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Mitofusin-2 is required for mouse oocyte meiotic maturation [PDF]
Scientific Reports, 2016 AbstractMitofusin-2 (Mfn2) is essential for embryonic development, anti-apoptotic events, protection against free radical-induced lesions and mitochondrial fusion in many cells. However, little is known about its mechanism and function during oocyte maturation.
Jing-Hua Zhang +10 more
openaire +2 more sources
Mitofusin 2 immunofluorescence assay.
, 2014 Photomicrographs showing kidney mitofusin 2 immunostaining of lean (a, e), ob/ob (b, f) and ob/ob treated with melatonin (c) mice and relative quantitative analyses of immunopositivity (d).
Rita Rezzani (649640) +6 more
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Mitofusin 2 protects hepatocyte mitochondrial function from damage induced by GCDCA. [PDF]
PLoS ONE, 2013 Mitochondrial impairment is hypothesized to contribute to the pathogenesis of chronic cholestatic liver diseases. Mitofusin 2 (Mfn2) regulates mitochondrial morphology and signaling and is involved in the development of numerous mitochondrial-related ...
Yongbiao Chen +5 more
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Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation. [PDF]
J Leukoc Biol, 2022 AbstractNeutrophils are critical for inflammation and innate immunity, and their adhesion to vascular endothelium is a crucial step in neutrophil recruitment. Mitofusin-2 (MFN2) is required for neutrophil adhesion, but molecular details are unclear. Here, we demonstrated that β2-integrin-mediated slow-rolling and arrest, but not PSGL-1-mediated cell ...
Liu W +12 more
europepmc +3 more sources
Mitofusin 1 and Mitofusin 2 Function in the Context of Brain Development
, 2011 Mitofusin 1 and 2 are outer-mitochondrial membrane proteins that have been shown to be involved in fusion. Mitofusin 2 has also been associated with apoptosis and development.
Hamze, Carmen
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, 2012 Mitochondria play central roles in integrating pro- and antiapoptotic stimuli, and JNK is well known to have roles in activating apoptotic pathways. We establish a critical link between stress-induced JNK activation, mitofusin 2, which is an essential ...
Leboucher, Guillaume P. +7 more
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Mitofusin 2: A link between mitochondrial function and substrate metabolism?
, 2021 Mitochondria are dynamic, interactive organelles that connect cellular signaling and whole-cell homeostasis. This "mitochatting" allows the cell to receive information about the mitochondria's condition before accommodating energy demands.
Ortiz, Rudy M, Emery, Janna M
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