Results 41 to 50 of about 17,663,383 (215)

Piperine Derivatives Enhance Fusion and Axonal Transport of Mitochondria by Activating Mitofusins

Chemistry, 2022
Piperine (1-piperoylpiperidine) is the major pungent component of black pepper (Piper nigrum) and exhibits a spectrum of pharmacological activities. The molecular bases for many of piperine’s biological effects are incompletely defined. We noted that the
Lihong Zhang, Xiawei Dang, Antonietta Franco, Haiyang Zhao, Gerald W. Dorn   +4 more
doaj   +1 more source

Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity

, 2021
Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small molecule mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach.
Sidney B. Williams (11306623), Sriram Devanathan (474812), Gerald W. Dorn (7327829), Xiawei Dang (8992400), Daniel Walters (391478), Antonietta Franco (760360), Lijun Fu (120480), Peter R. Bernstein (2004739)   +7 more
core   +4 more sources

Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease. [PDF]

, 2016
Mutations in PINK1 and PARKIN cause early-onset Parkinson's disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1 and parkin mutants, defective mitochondria also give rise to endoplasmic reticulum (ER) stress ...
C. Jones (2411536), I. Celardo (7631555), S. H. Loh (5409680), L. Miguel Martins (7584008), N. E. Mencacci (7671122), N. Wood (7671119), A. C. Costa (5187086), G. R. Mallucci (7671125), S. Lehmann (1354539)   +8 more
core   +2 more sources

On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria tethering [PDF]

Proceedings of the National Academy of Sciences, 2017
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Greotti E, Turacchio G, Luini A, Pozzan T, Pizzo P, Filadi R   +5 more
openaire   +4 more sources

Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death

Cells, 2020
It is believed that mitochondrial fragmentation cause mitochondrial dysfunction and neuronal deficits in Alzheimer’s disease. We recently reported that constitutive knockout of the mitochondria fusion protein mitofusin2 (Mfn2) in the mouse brain ...
Song Han, Priya Nandy, Quillan Austria, Sandra L. Siedlak, Sandy Torres, Hisashi Fujioka, Wenzhang Wang, Xiongwei Zhu   +7 more
doaj   +1 more source

Structure, function, and regulation of mitofusin‐2 in health and disease [PDF]

Biological Reviews, 2017
ABSTRACTMitochondria are highly dynamic organelles that constantly migrate, fuse, and divide to regulate their shape, size, number, and bioenergetic function. Mitofusins (Mfn1/2), optic atrophy 1 (OPA1), and dynamin‐related protein 1 (Drp1), are key regulators of mitochondrial fusion and fission.
Gursimran Chandhok, Michael Lazarou, Brent Neumann   +2 more
openaire   +2 more sources

Mitofusin-2 is a novel anti-angiogenic factor in pancreatic cancer [PDF]

Journal of Gastrointestinal Oncology, 2021
Aberrant expression of mitofusin-2 (MFN2) has been found to be associated with vascular endothelial growth factor A (VEGFA)-mediated angiogenesis in human umbilical vein endothelial cells (HUVECs). This study aimed to investigate the expression of MFN2 in pancreatic cancer (PC) and the role of MFN2 in vascular endothelial cell growth and angiogenesis ...
Zhichuan, Lin, Xiaoyi, Lin, Jinhong, Chen, Guoqiang, Huang, Tangen, Chen, Liling, Zheng   +5 more
openaire   +2 more sources

Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts [PDF]

, 2022
Dominant mutations in ubiquitously expressed Mitofusin 2 gene (MFN2) cause Charcot-Marie-Tooth type 2A (CMT2A; OMIM 609260), an inherited sensory-motor neuropathy that affects peripheral nerve axons.
Doccini, Stefano, Pafundi, Mariella, Girolamo, Francesco, Zanfardino, Paola, Cox, Sharon N, Manzari, Caterina, Petruzzella, Vittoria, Longo, Giovanna, Amati, Alessandro, Morani, Federica, Picardi, Ernesto, Santorelli, Filippo M, Tullo, Apollonia   +12 more
core   +1 more source

Loss of Mitofusin 2 Promotes Endoplasmic Reticulum Stress [PDF]

Journal of Biological Chemistry, 2012
The outer mitochondrial membrane GTPase mitofusin 2 (Mfn2) is known to regulate endoplasmic reticulum (ER) shape in addition to its mitochondrial fusion effects. However, its role in ER stress is unknown. We report here that induction of ER stress with either thapsigargin or tunicamycin in mouse embryonic fibroblasts leads to up-regulation of Mfn2 mRNA
Gladys A, Ngoh, Kyriakos N, Papanicolaou, Kenneth, Walsh   +2 more
openaire   +2 more sources

Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages

Frontiers in Immunology, 2021
Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria.
Vera Khodzhaeva, Yannick Schreiber, Gerd Geisslinger, Gerd Geisslinger, Ralf P. Brandes, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Dmitry Namgaladze   +9 more
doaj   +1 more source