Modulating mitofusins to control mitochondrial function and signaling [PDF]
Nature Communications, 2022 Mitofusins regulate mitochondrial fusion. Here the authors identify small molecules that activate or inhibit mitofusins’ activity and modulate mitochondrial fusion and functionality.
Emmanouil Zacharioudakis +20 more
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Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.
PLoS ONE, 2011 PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy ...
Aleksandar Rakovic +6 more
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A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly [PDF]
Nature CommunicationsThe mitochondrion is a highly dynamic organelle, constantly undergoing fusion and fission, which are critical processes for the health of cells. Fusion of the outer mitochondrial membrane (OMM) is mediated by the mitofusins belonging to the dynamin ...
Shu-Jing Huang +16 more
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Lipidomics reveals the reshaping of the mitochondrial phospholipid profile in cells lacking OPA1 and mitofusins [PDF]
Journal of Lipid ResearchDepletion or mutations of key proteins for mitochondrial fusion, like optic atrophy 1 (OPA1) and mitofusins 1 and 2 (Mfn 1 and 2), are known to significantly impact the mitochondrial ultrastructure, suggesting alterations of their membranes’ lipid ...
Andrea Castellaneta +12 more
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Mitochondrial AK3 inhibits nuclear β-catenin localization and its activation through enhancing mitochondrial activity [PDF]
Cell Death and DiseaseThe aberrant Wnt/β-catenin signaling is tightly associated with developmental disorders and tumorigenesis. However, spatial regulation of cytoplasmic β-catenin with regard to its nuclear accumulation and signaling activation remains poorly understood ...
Muhah Jeong +7 more
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iScience, 2023 Summary: Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power membrane-remodeling events via self-interaction and GTP hydrolysis.
Ira Buntenbroich +8 more
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Piperine Derivatives Enhance Fusion and Axonal Transport of Mitochondria by Activating Mitofusins
Chemistry, 2022 Piperine (1-piperoylpiperidine) is the major pungent component of black pepper (Piper nigrum) and exhibits a spectrum of pharmacological activities. The molecular bases for many of piperine’s biological effects are incompletely defined. We noted that the
Lihong Zhang +4 more
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Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells [PDF]
Frontiers in Cell and Developmental BiologyMitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these include elongated mitochondria in the inner segments and a distinct ...
Michael Landowski +24 more
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Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease [PDF]
Frontiers in Cell and Developmental BiologyMitochondrial dynamics, involving fission and fusion, are vital for maintaining mitochondrial quality, shape, and function in heart cells. This review explores how key regulators—Dynamin-related protein 1 (Drp1), mitofusins 1 and 2 (Mfn1/2), and Optic ...
Tengxu Zhang +5 more
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Pathogenic roles of the IMNEPD-associated PTRH2 mutants in aggravating mitochondrial dynamics and its rescue [PDF]
Molecular MedicineBackground Mitochondrial dynamics, orchestrated by a finely tuned balance between fusion and fission, are critical for cellular homeostasis and development.
DoHyeong Na +7 more
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