Modulating mitofusins to control mitochondrial function and signaling [PDF]
Nature Communications, 2022 Mitofusins regulate mitochondrial fusion. Here the authors identify small molecules that activate or inhibit mitofusins’ activity and modulate mitochondrial fusion and functionality.
Boǧos Agianian +2 more
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Role of Mitofusins and Mitophagy in Life or Death Decisions [PDF]
Frontiers in Cell and Developmental Biology, 2020 Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy ...
Mafalda Escobar-Henriques +1 more
exaly +5 more sources
Mitochondrial AK3 inhibits nuclear β-catenin localization and its activation through enhancing mitochondrial activity [PDF]
Cell Death and DiseaseThe aberrant Wnt/β-catenin signaling is tightly associated with developmental disorders and tumorigenesis. However, spatial regulation of cytoplasmic β-catenin with regard to its nuclear accumulation and signaling activation remains poorly understood ...
Muhah Jeong +7 more
doaj +2 more sources
A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly [PDF]
Nature CommunicationsThe mitochondrion is a highly dynamic organelle, constantly undergoing fusion and fission, which are critical processes for the health of cells. Fusion of the outer mitochondrial membrane (OMM) is mediated by the mitofusins belonging to the dynamin ...
Shu-Jing Huang +16 more
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Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases
Frontiers in Physiology, 2019 Mitochondria are dynamic organelles engaged in quality control and aging processes. They constantly undergo fusion, fission, transport, and anchoring events, which empower mitochondria with a very interactive behavior.
Mafalda Escobar-Henriques +1 more
exaly +3 more sources
Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts
PLoS ONE, 2011 PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy ...
Aleksandar Rakovic +2 more
exaly +2 more sources
Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells [PDF]
Frontiers in Cell and Developmental BiologyMitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these include elongated mitochondria in the inner segments and a distinct ...
Michael Landowski +24 more
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Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease [PDF]
Frontiers in Cell and Developmental BiologyMitochondrial dynamics, involving fission and fusion, are vital for maintaining mitochondrial quality, shape, and function in heart cells. This review explores how key regulators—Dynamin-related protein 1 (Drp1), mitofusins 1 and 2 (Mfn1/2), and Optic ...
Tengxu Zhang +5 more
doaj +2 more sources
Pathogenic roles of the IMNEPD-associated PTRH2 mutants in aggravating mitochondrial dynamics and its rescue [PDF]
Molecular MedicineBackground Mitochondrial dynamics, orchestrated by a finely tuned balance between fusion and fission, are critical for cellular homeostasis and development.
DoHyeong Na +7 more
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High intensity interval training alters gene expression linked to mitochondrial biogenesis and dynamics in high fat diet fed rats [PDF]
Scientific ReportsA High-Fat Diet (HFD) leads to disruption of mitochondrial biogenesis and dynamics. Exercise training, especially High-Intensity Interval Training (HIIT) increases mitochondrial biogenesis and dynamics.
Mohammad Jahangiri +2 more
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