Modulating mitofusins to control mitochondrial function and signaling
Nature Communications, 2022 Mitofusins regulate mitochondrial fusion. Here the authors identify small molecules that activate or inhibit mitofusins’ activity and modulate mitochondrial fusion and functionality.
Boǧos Agianian +2 more
exaly +2 more sources
Role of Mitofusins and Mitophagy in Life or Death Decisions
Frontiers in Cell and Developmental Biology, 2020 Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy ...
Mafalda Escobar-Henriques
exaly +3 more sources
Mitochondrial fusion is required for spermatogonial differentiation and meiosis [PDF]
eLife, 2019 Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Grigor Varuzhanyan +6 more
doaj +3 more sources
A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly [PDF]
Nature CommunicationsThe mitochondrion is a highly dynamic organelle, constantly undergoing fusion and fission, which are critical processes for the health of cells. Fusion of the outer mitochondrial membrane (OMM) is mediated by the mitofusins belonging to the dynamin ...
Shu-Jing Huang +16 more
doaj +2 more sources
Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases
Frontiers in Physiology, 2019 Mitochondria are dynamic organelles engaged in quality control and aging processes. They constantly undergo fusion, fission, transport, and anchoring events, which empower mitochondria with a very interactive behavior.
Mafalda Escobar-Henriques
exaly +3 more sources
Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion [PDF]
Molecular Biology of the Cell, 2009 Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases—OPA1 and the mitofusins Mfn1 and Mfn2—are essential for the fusion of mammalian mitochondria.
Zhiyin Song +2 more
exaly +4 more sources
Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts
PLoS ONE, 2011 PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy ...
Aleksandar Rakovic +2 more
exaly +2 more sources
Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease [PDF]
Frontiers in Cell and Developmental BiologyMitochondrial dynamics, involving fission and fusion, are vital for maintaining mitochondrial quality, shape, and function in heart cells. This review explores how key regulators—Dynamin-related protein 1 (Drp1), mitofusins 1 and 2 (Mfn1/2), and Optic ...
Tengxu Zhang +5 more
doaj +2 more sources
Pathogenic roles of the IMNEPD-associated PTRH2 mutants in aggravating mitochondrial dynamics and its rescue [PDF]
Molecular MedicineBackground Mitochondrial dynamics, orchestrated by a finely tuned balance between fusion and fission, are critical for cellular homeostasis and development.
DoHyeong Na +7 more
doaj +2 more sources
Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution [PDF]
Cell Reports, 2018 Summary: Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors.
Tatiana Trevisan +5 more
doaj +4 more sources