Results 1 to 10 of about 17,983 (257)
The role of Mitofusin-1 and Mitofusin-2 in periodontal disease: a comprehensive review [PDF]
Frontiers in Oral HealthPeriodontal disease is a widespread chronic inflammatory state influencing the supporting anatomy of the teeth, distinguished by oxidative stress, progressive bone loss, and tissue damage.
Sudhir Rama Varma, Asok Mathew
exaly +6 more sources
Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. [PDF]
PLoS ONE, 2016 Charcot-Marie-Tooth disease type 2A (CMT2A), the most common axonal form of hereditary sensory motor neuropathy, is caused by mutations of mitofusin-2 (MFN2). Mitofusin-2 is a GTPase required for fusion of mitochondrial outer membranes, repair of damaged
Peter Bannerman +4 more
doaj +11 more sources
Cell Reports, 2020 Summary: Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play a major role in inflammation, we studied the contribution of Mfn2 to the ...
Pere-Joan Cardona +2 more
exaly +3 more sources
Mitochondrial fusion is required for spermatogonial differentiation and meiosis [PDF]
eLife, 2019 Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Grigor Varuzhanyan +6 more
doaj +3 more sources
The effects of endurance training and estrogen-related receptor α disruption on mitofusin 1 and 2, GLUT2, PPARβ/δ and SCD1 expression in the liver of diabetic rats [PDF]
The Ukrainian Biochemical Journal, 2020 Diabetes is a progressive and metabolic disease with a high prevalence throughout the world. Physical activity is considered as an intervention to improve diabetes. Intervention such as estrogen-related receptor α (ERRα) inhibition is considered as a new
B. Shahouzehi +3 more
doaj +1 more source
Life Science Alliance, 2023 Our analysis of a CMT2A-associated mitofusin variant reveals that aberrant mitochondrial tethering results in perinuclear clusters and that conformational dynamics in Hinge 2 are required to progress from membrane tethering to membrane fusion.
Stephanie R Sloat, Suzanne Hoppins
doaj +1 more source
Cells, 2022 Mitochondrial fusion is essential to mitochondrial fitness and cellular health. Neurons of patients with genetic neurodegenerative diseases often exhibit mitochondrial fragmentation, reflecting an imbalance in mitochondrial fusion and fission ...
Xiawei Dang +5 more
doaj +1 more source
eLife, 2023 Mitochondrial dysfunction has been reported in obesity and insulin resistance, but primary genetic mitochondrial dysfunction is generally not associated with these, arguing against a straightforward causal relationship.
Jake P Mann +16 more
doaj +1 more source
Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study. [PDF]
PLoS ONE, 2012 Besides its role in controlling the morphology of mitochondria, mitofusin-2 has been proposed to tether mitochondria to the endoplasmic reticulum (ER), based largely on light microscopic analysis. In this study we have examined by electron microscopy the
Pierre Cosson +3 more
doaj +1 more source
Adropin Alleviates Myocardial Fibrosis in Diabetic Cardiomyopathy Rats: A Preliminary Study
Frontiers in Cardiovascular Medicine, 2021 Aim: Adropin (ADR) is a novel regulatory polypeptide and has important effects on energy metabolism in the heart. However, it is still unclear whether ADR can relieve ventricular remodeling in DCM. Therefore, this study was conducted to assess the effect
Mao Liu +5 more
doaj +1 more source