Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease [PDF]
Journal of Periodontology, 2023 BackgroundMitochondria and endoplasmic reticulum are key cellular organelles and create contact sites (mitochondria-endoplasmic reticulum contact [MERC]), which plays a major role in calcium metabolism, apoptotic processes, and inflammation.
Sabanci, Arife +11 more
core +3 more sources
Mitofusin 2: from functions to disease [PDF]
Cell Death & Disease, 2018 Mitochondria are highly dynamic organelles whose functions are essential for cell viability. Within the cell, the mitochondrial network is continuously remodeled through the balance between fusion and fission events.
Filadi, Riccardo +5 more
core +6 more sources
Mitophagy: Mitofusin Recruits a Mitochondrial Killer [PDF]
Current Biology, 2013 SummaryParkin is a cytosolic ubiquitin ligase that translocates to damaged mitochondria and promotes their degradation. Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin ...
Pallanck, Leo
core +4 more sources
Mitofusin 1 and Mitofusin 2 Function in the Context of Brain Development [PDF]
, 2011 Mitofusin 1 and 2 are outer-mitochondrial membrane proteins that have been shown to be involved in fusion. Mitofusin 2 has also been associated with apoptosis and development.
Hamze, Carmen
core +5 more sources
Mitofusin 2 Exerts a Protective Role in Ischemia Reperfusion Injury Through Increasing Autophagy [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Autophagy is essential for maintaining cellular homeostasis and the survival of terminally differentiated cells as neurons. In this study, we aim to investigate whether mitofusin 2, a mitochondrial fusion protein, mediates autophagy in ...
Cheng Peng +12 more
doaj +4 more sources
Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A [PDF]
eLife, 2020 Charcot–Marie-Tooth disease type 2A (CMT2A) is an untreatable childhood peripheral neuropathy caused by mutations of the mitochondrial fusion protein, mitofusin (MFN) 2.
Antonietta Franco +10 more
doaj +3 more sources
Back to The Fusion: Mitofusin-2 in Alzheimer's Disease [PDF]
Journal of Clinical Medicine, 2020 Mitochondria are dynamic organelles that undergo constant fission and fusion. Mitochondria dysfunction underlies several human disorders, including Alzheimer's disease (AD).
Agnese Graziosi +7 more
core +8 more sources
Mitofusin 2 Deficiency Affects Energy Metabolism and Mitochondrial Biogenesis in MEF Cells. [PDF]
PLoS ONE, 2015 Mitofusin 2 (Mfn2), mitochondrial outer membrane protein which is involved in rearrangement of these organelles, was first described in pathology of hypertension and diabetes, and more recently much attention is paid to its functions in Charcot-Marie ...
Maria Kawalec +5 more
doaj +3 more sources
Structural dataset from microsecond-long simulations of yeast mitofusin Fzo1 in the context of membrane docking [PDF]
Data in Brief, 2019 In this work we present a novel set of possible auto-oligomerisation states of yeast protein Fzo1 in the context of membrane docking. The dataset reports atomistic models and trajectories derived from a molecular dynamics study of the yeast mitofusin ...
Astrid Brandner +4 more
doaj +3 more sources
A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake [PDF]
Redox Biology, 2020 UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-cellular localization dependent on its farnesylation state. Despite UCH-L1′s association with familial Parkinson's Disease (PD), the effects on mitochondrial bioenergetics ...
Fernanda M. Cerqueira +9 more
doaj +3 more sources