Results 31 to 40 of about 13,532 (177)
Frontiers in Molecular Neuroscience, 2018 Friedreich’s ataxia (FRDA) is the most important recessive ataxia in the Caucasian population. It is caused by a deficit of the mitochondrial protein frataxin.
Oliver Edenharter +2 more
doaj +1 more source
A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro
eLife, 2016 Fusion of mitochondrial outer membranes is crucial for proper organelle function and involves large GTPases called mitofusins. The discrete steps that allow mitochondria to attach to one another and merge their outer membranes are unknown.
Tobias Brandt +3 more
doaj +1 more source
Endoplasmic Reticulum Stress and Mitochondrial Function in Airway Smooth Muscle
Frontiers in Cell and Developmental Biology, 2020 Inflammatory airway diseases such as asthma affect more than 300 million people world-wide. Inflammation triggers pathophysiology via such as tumor necrosis factor α (TNFα) and interleukins (e.g., IL-13).
Philippe Delmotte, Gary C. Sieck
doaj +1 more source
Doxorubicin and 4-Hydroperoxycyclophosphamide Alter Mitochondrial Dynamics and miR-34 Expression in Spermatogonia and Spermatocytes In Vitro. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Doxorubicin (DOX) and cyclophosphamide (CP) are widely used chemotherapeutic agents with known gonadotoxic effects. Since miRNAs play a key role in the transcriptional regulation of spermatogenesis, they are suggested as biomarkers for male infertility.
Öztatlıcı H +4 more
europepmc +2 more sources
Frontiers in Neuroscience, 2019 Parkinson’s disease (PD) is characterized by selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc). α-synuclein (α-syn) is known to regulate mitochondrial function and both PINK1 and Parkin have been shown ...
Mahesh Ramalingam +2 more
doaj +1 more source
The Effect of a Novel c.820C>T (Arg274Trp) Mutation in the Mitofusin 2 Gene on Fibroblast Metabolism and Clinical Manifestation in a Patient. [PDF]
PLoS ONE, 2017 Charcot-Marie-Tooth disease type 2A (CMT2A) is an autosomal dominant axonal peripheral neuropathy caused by mutations in the mitofusin 2 gene (MFN2).
Małgorzata Beręsewicz +7 more
doaj +1 more source
Mitophagy: Mitofusin Recruits a Mitochondrial Killer [PDF]
, 2013 SummaryParkin is a cytosolic ubiquitin ligase that translocates to damaged mitochondria and promotes their degradation. Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin ...
Pallanck, Leo
core +1 more source
The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes
Communications Biology, 2022 The MFN1 and MFN2 mitofusin proteins localize to the outer mitochondrial membrane, where they may help functionally tether mitochondria to peroxisomes.
Yinbo Huo +4 more
doaj +1 more source
iScience, 2023 Summary: Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power membrane-remodeling events via self-interaction and GTP hydrolysis.
Ira Buntenbroich +8 more
doaj +1 more source
Mitofusin 2: from functions to disease [PDF]
, 2018 Mitochondria are highly dynamic organelles whose functions are essential for cell viability. Within the cell, the mitochondrial network is continuously remodeled through the balance between fusion and fission events.
Filadi, Riccardo +5 more
core +1 more source