Results 41 to 50 of about 12,758 (225)
The Effects of Regulatory Lipids on Intracellular Membrane Fusion Mediated by Dynamin-Like GTPases
Frontiers in Cell and Developmental Biology, 2020 Membrane fusion mediates a number of fundamental biological processes such as intracellular membrane trafficking, fertilization, and viral infection. Biological membranes are composed of lipids and proteins; while lipids generally play a structural role,
Yeojin Moon, Youngsoo Jun
doaj +1 more source
Mitofusin 2 immunofluorescence assay. [PDF]
, 2014 Photomicrographs showing kidney mitofusin 2 immunostaining of lean (a, e), ob/ob (b, f) and ob/ob treated with melatonin (c) mice and relative quantitative analyses of immunopositivity (d).
Rita Rezzani (649640) +6 more
core +1 more source
Intra- and Intercellular Quality Control Mechanisms of Mitochondria
Cells, 2017 Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases.
Yoshimitsu Kiriyama, Hiromi Nochi
doaj +1 more source
Mitofusins: Mighty Regulators of Metabolism [PDF]
Cell, 2013 Mitochondria are central regulators of cellular metabolism but how their function in a subset of cells affects whole-body energy balance is less understood. Two studies in this issue of Cell identify how diet-dependent modulation of mitochondrial fusion in specific neuronal circuits impact the metabolic status of an animal.
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2018 Friedreich’s ataxia (FRDA) is the most important recessive ataxia in the Caucasian population. It is caused by a deficit of the mitochondrial protein frataxin.
Oliver Edenharter +2 more
doaj +1 more source
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy [PDF]
Human Molecular Genetics, 2010 Mitochondrial dysfunction and perturbed degradation of proteins have been implicated in Parkinson's disease (PD) pathogenesis. Mutations in the Parkin and PINK1 genes are a cause of familial PD. PINK1 is a putative kinase associated with mitochondria, and loss of PINK1 expression leads to mitochondrial dysfunction, which increases with time.
Matthew E, Gegg +5 more
openaire +2 more sources
Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis [PDF]
, 2012 Mitochondria play central roles in integrating pro- and antiapoptotic stimuli, and JNK is well known to have roles in activating apoptotic pathways. We establish a critical link between stress-induced JNK activation, mitofusin 2, which is an essential ...
Leboucher, Guillaume P. +7 more
core +1 more source
Endoplasmic Reticulum Stress and Mitochondrial Function in Airway Smooth Muscle
Frontiers in Cell and Developmental Biology, 2020 Inflammatory airway diseases such as asthma affect more than 300 million people world-wide. Inflammation triggers pathophysiology via such as tumor necrosis factor α (TNFα) and interleukins (e.g., IL-13).
Philippe Delmotte, Gary C. Sieck
doaj +1 more source
Control of mitochondrial morphology by a human mitofusin [PDF]
Journal of Cell Science, 2001 ABSTRACT Although changes in mitochondrial size and arrangement accompany both cellular differentiation and human disease, the mechanisms that mediate mitochondrial fusion, fission and morphogenesis in mammalian cells are not understood. We have identified two human genes encoding potential mediators of mitochondrial fusion.
A, Santel, M T, Fuller
openaire +2 more sources
A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro
eLife, 2016 Fusion of mitochondrial outer membranes is crucial for proper organelle function and involves large GTPases called mitofusins. The discrete steps that allow mitochondria to attach to one another and merge their outer membranes are unknown.
Tobias Brandt +3 more
doaj +1 more source