Results 61 to 70 of about 13,532 (177)
Mitofusin 2 Builds a Bridge between ER and Mitochondria [PDF]
, 2008 Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2—tethering
Merkwirth, Carsten +3 more
core +1 more source
Role of Mitofusins and Mitophagy in Life or Death Decisions
Frontiers in Cell and Developmental Biology, 2020 Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy ...
Mariana Joaquim +1 more
doaj +1 more source
Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome
Annals of Neurology, EarlyView.Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca +24 more
wiley +1 more source
Complementation of mitofusin-2 KO cells.
, 2013 Mfn2 KO cells were transfected with a plasmid driving the expression of Mitofusin-2 fused to GFP. Cells expressing moderate levels of fluorescence were sorted, re-grown, fixed and processed as described in the legend to Fig. 1.
Pierre Cosson (290984) +3 more
core +1 more source
Functional characterization of the membrane bound E3 ligase MARCH5 and its substrate Mitofusin-2
, 2022 Mitochondrial integrity relies on balanced fission and fusion events. The ubiquitination, mediated by the mitochondrial membrane-bound ubiquitin ligase MARCH5, is crucial for the regulation of these mitochondrial dynamics by targeting proteins of the ...
Merklinger, Lisa
core
Nature Communications, 2021 Endothelial tissues must have intact barrier function, but this may be disrupted during inflammation. Here, the authors show that the mitochondrial protein Mitofusin-2 stabilizes cell–cell adherens junctions in endothelial cells during homeostasis and ...
Young-Mee Kim +7 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang +22 more
wiley +1 more source
Prevention of Early Onset of Breast Cancer With Ashwagandha
Molecular Carcinogenesis, EarlyView.ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm +2 more
wiley +1 more source
Phytotherapy Research, EarlyView.Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng +6 more
wiley +1 more source
New trick for an old dog - Mitofusin controls peroxisomal dynamics in stem cells
, 2023 Adult stem cells make up an important reservoir of progenitor cells capable regenerating tissues and organs throughout lifetime. Several signaling pathways have been characterized to influence the decision stem cells make between self-renewing (i.e ...
Kumar, Tanushree +3 more
core +1 more source