The role of Mitofusin-1 and Mitofusin-2 in periodontal disease: a comprehensive review [PDF]
Frontiers in Oral HealthPeriodontal disease is a widespread chronic inflammatory state influencing the supporting anatomy of the teeth, distinguished by oxidative stress, progressive bone loss, and tissue damage.
Sudhir R. Varma +6 more
exaly +4 more sources
Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity [PDF]
Virulence, 2021 Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli.
In Soo Kim +2 more
exaly +3 more sources
A human mitofusin 2 mutation can cause mitophagic cardiomyopathy [PDF]
eLife, 2023 Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15–20× over-represented in
Antonietta Franco +12 more
doaj +2 more sources
Mitochonic acid 5 regulates mitofusin 2 to protect microglia [PDF]
Neural Regeneration Research, 2021 Microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis.
Jian Tan +7 more
doaj +2 more sources
Mitofusin 2 displays fusion-independent roles in proteostasis surveillance [PDF]
Nature CommunicationsMitochondria are essential organelles and their functional state dictates cellular proteostasis. However, little is known about the molecular gatekeepers involved, especially in absence of external stress.
Mariana Joaquim +18 more
doaj +2 more sources
The structure and function of mitofusin 2 and its role in cardiovascular disease through mediating mitochondria-associated endoplasmic reticulum membranes [PDF]
Frontiers in Cardiovascular MedicineCardiovascular disease (CVD) remains a leading cause of death globally, posing a major public health challenge. Due to the complexity of CVD's etiology, understanding its pathogenesis has been a significant challenge and research focus.
Yuhu Lv +9 more
doaj +2 more sources
Autophagy and proliferation are dysregulated in Charcot-Marie-Tooth disease type 2A cells harboring MFN2 (mitofusin 2) mutation [PDF]
Autophagy Reports, 2022 MFN2 (mitofusin 2) is a mitochondrial outer membrane protein that serves primarily as a mitochondrial fusion protein, which is its best known role but has additional functions in regulating cell biological processes.
Paola Zanfardino, Vittoria Petruzzella
doaj +2 more sources
Mitofusin-2: A New Mediator of Pathological Cell Proliferation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cell proliferation is an important cellular process for physiological tissue homeostasis and remodeling. The mechanisms of cell proliferation in response to pathological stresses are not fully understood.
Yanguo Xin +4 more
doaj +2 more sources
Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation [PDF]
Cells, 2022 Inter-organellar communication is emerging as one of the most crucial regulators of cellular physiology. One of the key regulators of inter-organellar communication is Mitofusin-2 (MFN2).
Jyoti Tanwar +12 more
doaj +2 more sources
Life Science Alliance, 2023 Our analysis of a CMT2A-associated mitofusin variant reveals that aberrant mitochondrial tethering results in perinuclear clusters and that conformational dynamics in Hinge 2 are required to progress from membrane tethering to membrane fusion.
Stephanie R Sloat, Suzanne Hoppins
doaj +1 more source