The role of Mitofusin-1 and Mitofusin-2 in periodontal disease: a comprehensive review [PDF]
Frontiers in Oral HealthPeriodontal disease is a widespread chronic inflammatory state influencing the supporting anatomy of the teeth, distinguished by oxidative stress, progressive bone loss, and tissue damage.
Sudhir Rama Varma, Asok Mathew
exaly +4 more sources
Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity [PDF]
Virulence, 2021 Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli.
In Soo Kim +2 more
exaly +3 more sources
A human mitofusin 2 mutation can cause mitophagic cardiomyopathy [PDF]
eLife, 2023 Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15–20× over-represented in
Antonietta Franco +12 more
doaj +2 more sources
Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. [PDF]
PLoS ONE, 2016 Charcot-Marie-Tooth disease type 2A (CMT2A), the most common axonal form of hereditary sensory motor neuropathy, is caused by mutations of mitofusin-2 (MFN2). Mitofusin-2 is a GTPase required for fusion of mitochondrial outer membranes, repair of damaged
Peter Bannerman +4 more
doaj +7 more sources
Mitochonic acid 5 regulates mitofusin 2 to protect microglia [PDF]
Neural Regeneration Research, 2021 Microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis.
Jian Tan +7 more
doaj +2 more sources
Mitofusin 2 displays fusion-independent roles in proteostasis surveillance [PDF]
Nature CommunicationsMitochondria are essential organelles and their functional state dictates cellular proteostasis. However, little is known about the molecular gatekeepers involved, especially in absence of external stress.
Mariana Joaquim +18 more
doaj +2 more sources
The structure and function of mitofusin 2 and its role in cardiovascular disease through mediating mitochondria-associated endoplasmic reticulum membranes [PDF]
Frontiers in Cardiovascular MedicineCardiovascular disease (CVD) remains a leading cause of death globally, posing a major public health challenge. Due to the complexity of CVD's etiology, understanding its pathogenesis has been a significant challenge and research focus.
Yuhu Lv +9 more
doaj +2 more sources
Autophagy and proliferation are dysregulated in Charcot-Marie-Tooth disease type 2A cells harboring MFN2 (mitofusin 2) mutation [PDF]
Autophagy Reports, 2022 MFN2 (mitofusin 2) is a mitochondrial outer membrane protein that serves primarily as a mitochondrial fusion protein, which is its best known role but has additional functions in regulating cell biological processes.
Paola Zanfardino, Vittoria Petruzzella
doaj +2 more sources
Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation [PDF]
Cells, 2022 Inter-organellar communication is emerging as one of the most crucial regulators of cellular physiology. One of the key regulators of inter-organellar communication is Mitofusin-2 (MFN2).
Jyoti Tanwar +12 more
doaj +2 more sources
Life Science Alliance, 2023 Our analysis of a CMT2A-associated mitofusin variant reveals that aberrant mitochondrial tethering results in perinuclear clusters and that conformational dynamics in Hinge 2 are required to progress from membrane tethering to membrane fusion.
Stephanie R Sloat, Suzanne Hoppins
doaj +1 more source