The Effect of a Novel c.820C>T (Arg274Trp) Mutation in the Mitofusin 2 Gene on Fibroblast Metabolism and Clinical Manifestation in a Patient. [PDF]
PLoS ONE, 2017 Charcot-Marie-Tooth disease type 2A (CMT2A) is an autosomal dominant axonal peripheral neuropathy caused by mutations in the mitofusin 2 gene (MFN2).
Małgorzata Beręsewicz +7 more
doaj +3 more sources
Mitofusin 2 Deficiency Affects Energy Metabolism and Mitochondrial Biogenesis in MEF Cells. [PDF]
PLoS ONE, 2015 Mitofusin 2 (Mfn2), mitochondrial outer membrane protein which is involved in rearrangement of these organelles, was first described in pathology of hypertension and diabetes, and more recently much attention is paid to its functions in Charcot-Marie ...
Maria Kawalec +5 more
doaj +3 more sources
Mitofusin-2 Expression Is Implicated in Cervical Cancer Pathogenesis [PDF]
Anticancer Research, 2018 BACKGROUND/AIM: It remains unclear whether mitofusin-2 (MFN2) functions as a tumour suppressor or oncogene in cancer progression. In this study we, therefore, aimed to investigate the effect of MFN2 on the pathogenesis of cervical cancer.
현영민, 장향란, 안성용
core +5 more sources
Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight [PDF]
Cell Reports, 2019 Summary: We found that exposure of adult animals to calorie-dense foods rapidly abolished expression of mitofusin 2 (Mfn2), a gene promoting mitochondrial fusion and mitochondrion-endoplasmic reticulum interactions, in white and brown fat.
Giacomo Mancini +5 more
doaj +2 more sources
Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2 [PDF]
Cell Reports, 2016 Communication between organelles plays key roles in cell biology. In particular, physical and functional coupling of the endoplasmic reticulum (ER) and mitochondria is crucial for regulation of various physiological and pathophysiological processes. Here,
Riccardo Filadi +5 more
doaj +5 more sources
Prognostic impact of mitofusin 2 expression in colon cancer. [PDF]
Transl Cancer Res, 2022 Mitofusin 2 (MFN2) is involved in several biological processes, including cancer. MFN2 is downregulated in some types of cancer and inhibits cancer cell proliferation, migration, and invasion. However, the relationship between MFN2 and colon cancer remains unknown.In this study, MFN2 expression was investigated using The Cancer Genome Atlas (TCGA) and ...
Cheng X, Li Y, Liu F.
europepmc +3 more sources
Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity [PDF]
, 2021 Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small molecule mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach.
Sidney B. Williams (11306623) +7 more
core +7 more sources
Adropin Alleviates Myocardial Fibrosis in Diabetic Cardiomyopathy Rats: A Preliminary Study
Frontiers in Cardiovascular Medicine, 2021 Aim: Adropin (ADR) is a novel regulatory polypeptide and has important effects on energy metabolism in the heart. However, it is still unclear whether ADR can relieve ventricular remodeling in DCM. Therefore, this study was conducted to assess the effect
Mao Liu +5 more
doaj +1 more source
Mitofusin 2 but not mitofusin 1 mediates Bcl-XL-induced mitochondrial aggregation [PDF]
Journal of Cell Science, 2020 ABSTRACT Bcl-2 family proteins, as central players of the apoptotic program, participate in regulation of the mitochondrial network. Here, a quantitative live-cell fluorescence resonance energy transfer (FRET) two-hybrid assay was used to confirm the homo-/hetero-oligomerization of mitofusins 2 and 1 (MFN2 and MFN1), and also demonstrate
Mengyan Du +9 more
openaire +2 more sources
Piperine Derivatives Enhance Fusion and Axonal Transport of Mitochondria by Activating Mitofusins
Chemistry, 2022 Piperine (1-piperoylpiperidine) is the major pungent component of black pepper (Piper nigrum) and exhibits a spectrum of pharmacological activities. The molecular bases for many of piperine’s biological effects are incompletely defined. We noted that the
Lihong Zhang +4 more
doaj +1 more source