Results 31 to 40 of about 24,584,287 (169)

Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production

eLife, 2014
Mitochondrial fusion and fission affect the distribution and quality control of mitochondria. We show that Marf (Mitochondrial associated regulatory factor), is required for mitochondrial fusion and transport in long axons.
Hector Sandoval, Chi-Kuang Yao, Kuchuan Chen, Manish Jaiswal, Taraka Donti, Yong Qi Lin, Vafa Bayat, Bo Xiong, Ke Zhang, Gabriela David, Wu-Lin Charng, Shinya Yamamoto, Lita Duraine, Brett H Graham, Hugo J Bellen   +14 more
doaj   +1 more source

Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity

, 2021
Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small molecule mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach.
Sidney B. Williams (11306623), Sriram Devanathan (474812), Gerald W. Dorn (7327829), Xiawei Dang (8992400), Daniel Walters (391478), Antonietta Franco (760360), Lijun Fu (120480), Peter R. Bernstein (2004739)   +7 more
core   +4 more sources

Clinical and genetic characteristcs of hereditary motor and sensory neuropathy type IIA

Анналы клинической и экспериментальной неврологии, 2017
In this study, clinical manifestations of hereditary motor andsensory neuropathy type IIA (HMSN IIA, orCharcotMarieTooth disease type 2A) were analyzed in 22patients with the disease caused by different mutations of theMFN2 gene.
E. L. Dadali, O. A. Schagina, V. P. Fedotov   +2 more
doaj   +1 more source

Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages

Frontiers in Immunology, 2021
Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria.
Vera Khodzhaeva, Yannick Schreiber, Gerd Geisslinger, Gerd Geisslinger, Ralf P. Brandes, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Dmitry Namgaladze   +9 more
doaj   +1 more source

Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled [PDF]

Signal Transduction and Targeted Therapy
Camilla Aurora Franchino, Elisa Motori, Matteo Bergami   +2 more
doaj   +2 more sources

Mitofusin 2: from functions to disease [PDF]

, 2018
Mitochondria are highly dynamic organelles whose functions are essential for cell viability. Within the cell, the mitochondrial network is continuously remodeled through the balance between fusion and fission events.
Filadi, Riccardo, Riccardo Filadi, Pendin, Diana, Diana Pendin, Pizzo, Paola, Paola Pizzo   +5 more
core   +1 more source

Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts [PDF]

, 2022
Dominant mutations in ubiquitously expressed Mitofusin 2 gene (MFN2) cause Charcot-Marie-Tooth type 2A (CMT2A; OMIM 609260), an inherited sensory-motor neuropathy that affects peripheral nerve axons.
Doccini, Stefano, Pafundi, Mariella, Girolamo, Francesco, Zanfardino, Paola, Cox, Sharon N, Manzari, Caterina, Petruzzella, Vittoria, Longo, Giovanna, Amati, Alessandro, Morani, Federica, Picardi, Ernesto, Santorelli, Filippo M, Tullo, Apollonia   +12 more
core   +1 more source

Back to The Fusion: Mitofusin-2 in Alzheimer's Disease [PDF]

, 2020
Mitochondria are dynamic organelles that undergo constant fission and fusion. Mitochondria dysfunction underlies several human disorders, including Alzheimer's disease (AD).
Agnese Graziosi, Patrizia Hrelia, Giulia Sita, Sita, Giulia, Morroni, Fabiana, Fabiana Morroni, Hrelia, Patrizia, Graziosi, Agnese   +7 more
core   +3 more sources

Effect of Aerobic Exercise With Blood Flow Restriction on Mitochondrial Dynamics Proteins of Human Skeletal Muscles

The Journal of Qazvin University of Medical Sciences, 2020
Background Aerobic exercise with Blood Flow Restriction (BFR) plays an important role in skeletal muscle adaptation; however, the effects of this type of exercise on mitochondrial dynamics proteins are unclear.
Ali Aryashakib, Bahman Mirzaei, Payam Saidie   +2 more
doaj   +1 more source

MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites

Frontiers in Cell and Developmental Biology, 2022
Endoplasmic reticulum (ER) functions critically depend on a suitable ATP supply to fuel ER chaperons and protein trafficking. A disruption of the ability of the ER to traffic and fold proteins leads to ER stress and the unfolded protein response (UPR ...
Benjamin Gottschalk, Zhanat Koshenov, Olaf A. Bachkoenig, René Rost, Roland Malli, Wolfgang F. Graier, Wolfgang F. Graier   +6 more
doaj   +1 more source