Results 51 to 60 of about 12,377 (209)
eLife, 2014 Mitochondrial fusion and fission affect the distribution and quality control of mitochondria. We show that Marf (Mitochondrial associated regulatory factor), is required for mitochondrial fusion and transport in long axons.
Hector Sandoval +14 more
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On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria tethering [PDF]
Proceedings of the National Academy of Sciences, 2017 -------
Greotti E +5 more
openaire +4 more sources
Clinical and genetic characteristcs of hereditary motor and sensory neuropathy type IIA
Анналы клинической и экспериментальной неврологии, 2017 In this study, clinical manifestations of hereditary motor andsensory neuropathy type IIA (HMSN IIA, orCharcotMarieTooth disease type 2A) were analyzed in 22patients with the disease caused by different mutations of theMFN2 gene.
E. L. Dadali +2 more
doaj +1 more source
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages
Frontiers in Immunology, 2021 Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria.
Vera Khodzhaeva +9 more
doaj +1 more source
The Journal of Qazvin University of Medical Sciences, 2020 Background Aerobic exercise with Blood Flow Restriction (BFR) plays an important role in skeletal muscle adaptation; however, the effects of this type of exercise on mitochondrial dynamics proteins are unclear.
Ali Aryashakib +2 more
doaj +1 more source
Mitophagy: Mitofusin Recruits a Mitochondrial Killer [PDF]
, 2013 SummaryParkin is a cytosolic ubiquitin ligase that translocates to damaged mitochondria and promotes their degradation. Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin ...
Pallanck, Leo
core +1 more source
Structure, function, and regulation of mitofusin‐2 in health and disease [PDF]
Biological Reviews, 2017 ABSTRACTMitochondria are highly dynamic organelles that constantly migrate, fuse, and divide to regulate their shape, size, number, and bioenergetic function. Mitofusins (Mfn1/2), optic atrophy 1 (OPA1), and dynamin‐related protein 1 (Drp1), are key regulators of mitochondrial fusion and fission.
Gursimran Chandhok +2 more
openaire +2 more sources
MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites
Frontiers in Cell and Developmental Biology, 2022 Endoplasmic reticulum (ER) functions critically depend on a suitable ATP supply to fuel ER chaperons and protein trafficking. A disruption of the ability of the ER to traffic and fold proteins leads to ER stress and the unfolded protein response (UPR ...
Benjamin Gottschalk +6 more
doaj +1 more source
Loss of Mitofusin 2 Promotes Endoplasmic Reticulum Stress [PDF]
Journal of Biological Chemistry, 2012 The outer mitochondrial membrane GTPase mitofusin 2 (Mfn2) is known to regulate endoplasmic reticulum (ER) shape in addition to its mitochondrial fusion effects. However, its role in ER stress is unknown. We report here that induction of ER stress with either thapsigargin or tunicamycin in mouse embryonic fibroblasts leads to up-regulation of Mfn2 mRNA
Gladys A, Ngoh +2 more
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Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. [PDF]
PLoS ONE, 2016 Charcot-Marie-Tooth disease type 2A (CMT2A), the most common axonal form of hereditary sensory motor neuropathy, is caused by mutations of mitofusin-2 (MFN2). Mitofusin-2 is a GTPase required for fusion of mitochondrial outer membranes, repair of damaged
Peter Bannerman +4 more
doaj +1 more source