Results 61 to 70 of about 12,377 (209)

MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation

Autophagy Reports, 2022
Differentiating stem cells must adapt their mitochondrial metabolism to fit the needs of the mature differentiated cell. In a recent study, we observed that during differentiation to an endothelial phenotype, pluripotent stem cell mitochondria are ...
Priyanka Gajwani, Jalees Rehman
doaj   +1 more source

New insights into signal transduction pathways in adrenal steroidogenesis: role of mitochondrial fusion, lipid mediators, and MAPK phosphatases

Frontiers in Endocrinology, 2023
Hormone-receptor signal transduction has been extensively studied in adrenal gland. Zona glomerulosa and fasciculata cells are responsible for glucocorticoid and mineralocorticoid synthesis by adrenocorticotropin (ACTH) and angiotensin II (Ang II ...
María Mercedes Mori Sequeiros Garcia, María Mercedes Mori Sequeiros Garcia, Cristina Paz, Cristina Paz, Ana Fernanda Castillo, Ana Fernanda Castillo, Yanina Benzo, Yanina Benzo, Matías A. Belluno, Ariana Balcázar Martínez, Paula Mariana Maloberti, Paula Mariana Maloberti, Fabiana Cornejo Maciel, Fabiana Cornejo Maciel, Cecilia Poderoso, Cecilia Poderoso   +15 more
doaj   +1 more source

Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A [PDF]

, 2010
Charcot-Marie-Tooth disease type 2A is an autosomal dominant axonal form of peripheral neuropathy caused by mutations in the mitofusin 2 gene. Mitofusin 2 encodes a mitochondrial outer membrane protein that participates in mitochondrial fusion in ...
Courvoisier, Delphine, Poirot, O., Médard, J.J., Arnaud, E., Arnaud, Estelle, Poirot, Olivier, Cartoni, R., Martinou, J.C., Chrast, Roman, Chrast, R., Cartoni, Romain, Médard, Jean-Jacques, Martinou, Jean-Claude, Courvoisier, D.S.   +13 more
core   +1 more source

Frequent Losses of Heterozygosity in the Mitofusin 2 Gene in Hepatocellular Carcinoma: Their Relationship to Clinicopathological Features [PDF]

, 2013
Background The aim of the study was to determine the features of loss of heterozygosity in the mitofusin 2 gene and their association with clinicopathological characteristics of hepatocellular carcinoma.
Li Qu, Guoliang Wang, Hui Chen, Jianfeng Wei   +3 more
core   +1 more source

CMT2A harboring mitofusin 2 mutation with optic nerve atrophy and normal visual acuity [PDF]

, 2020
Charcot-Marie-Tooth (CMT) constitutes a group of heterogeneous hereditary motor and sensor neuropathies. Mutations in mitofusin-2 (MFN2) cause CMT type 2A by altering mitochondrial fusion and trafficking along with the axonal microtubule system.
D'oria F., Zoccolella S., Alessio G., Petruzzella V., Favale R. A., Rossetti G., Guerriero S.   +6 more
core   +1 more source

Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction

Neural Regeneration Research
Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis is induced and regulated after cerebral ischemic injury.
Jun Wen, Hao Tang, Mingfen Tian, Ling Wang, Qinghuan Yang, Yong Zhao, Xuemei Li, Yu Ren, Jiani Wang, Li Zhou, Yongjun Tan, Haiyun Wu, Xinrui Cai, Yilin Wang, Hui Cao, Jianfeng Xu, Qin Yang   +16 more
doaj   +1 more source

Unveiling the role of mitofusin proteins in periodontal inflammation: Mitofusin-1 and Mitofusin-2 perspectives

Tanta Dental Journal
Abstract Periodontal diseases result from the complex interplay between microbial pathogens and the host immune response. Emerging evidence suggests that alterations in mitochondrial dynamics proteins, particularly Mitofusin-1 (MFN1) and Mitofusin-2 (MFN2), contribute to the pathogenesis of periodontal inflammation.
Himani Sharma, Umang Tripathi
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source