Mitofusin 2: A link between mitochondrial function and substrate metabolism? [PDF]
, 2021 Mitochondria are dynamic, interactive organelles that connect cellular signaling and whole-cell homeostasis. This "mitochatting" allows the cell to receive information about the mitochondria's condition before accommodating energy demands.
Ortiz, Rudy M, Emery, Janna M
core +1 more source
Frontiers in Cell and Developmental Biology, 2022 Mitochondria are highly dynamic organelles and their activity is known to be regulated by changes in morphology via fusion and fission events. However, the role of mitochondrial dynamics on cellular differentiation remains largely unknown.
Tianren Wang +17 more
doaj +1 more source
Regulating a uniter: control of mitofusin 2 expression [PDF]
Cardiovascular Research, 2012 This editorial refers to ‘The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells’ by E. Sorianello et al. , pp. 38–47, this issue. Sorianello et al. 1 provide important new information on the regulation on mitofusin (Mfn)2 expression.
Anne A, Knowlton, Le, Chen
openaire +2 more sources
Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis [PDF]
, 2012 Mitochondria play central roles in integrating pro- and antiapoptotic stimuli, and JNK is well known to have roles in activating apoptotic pathways. We establish a critical link between stress-induced JNK activation, mitofusin 2, which is an essential ...
Leboucher, Guillaume P. +7 more
core +1 more source
Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts [PDF]
, 2022 Dominant mutations in ubiquitously expressed Mitofusin 2 gene (MFN2) cause Charcot-Marie-Tooth type 2A (CMT2A; OMIM 609260), an inherited sensory-motor neuropathy that affects peripheral nerve axons.
Doccini, Stefano +12 more
core +1 more source
Downregulation of Mitofusin 2 in Placenta Is Related to Preeclampsia [PDF]
BioMed Research International, 2016 Background. Mitofusin 2 (Mfn2) is a novel mitochondrial protein that is implicated in cellular proliferation and metabolism; however, the role of Mfn2 in preeclampsia (PE) remains unknown. This study aimed to explore the relationship between Mfn2 and PE.Method. Preeclamptic and normal pregnancies were enrolled in a comparative study.
Yu, Jun +3 more
openaire +2 more sources
Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled [PDF]
Signal Transduction and Targeted TherapyCamilla Aurora Franchino +2 more
doaj +2 more sources
Complementation of mitofusin-2 KO cells. [PDF]
, 2013 Mfn2 KO cells were transfected with a plasmid driving the expression of Mitofusin-2 fused to GFP. Cells expressing moderate levels of fluorescence were sorted, re-grown, fixed and processed as described in the legend to Fig. 1.
Pierre Cosson (290984) +3 more
core +1 more source
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy [PDF]
Human Molecular Genetics, 2010 Mitochondrial dysfunction and perturbed degradation of proteins have been implicated in Parkinson's disease (PD) pathogenesis. Mutations in the Parkin and PINK1 genes are a cause of familial PD. PINK1 is a putative kinase associated with mitochondria, and loss of PINK1 expression leads to mitochondrial dysfunction, which increases with time.
Matthew E, Gegg +5 more
openaire +2 more sources
Functional characterization of the membrane bound E3 ligase MARCH5 and its substrate Mitofusin-2 [PDF]
, 2022 Mitochondrial integrity relies on balanced fission and fusion events. The ubiquitination, mediated by the mitochondrial membrane-bound ubiquitin ligase MARCH5, is crucial for the regulation of these mitochondrial dynamics by targeting proteins of the ...
Merklinger, Lisa
core