Results 81 to 90 of about 12,377 (209)

Role of mitofusin 2 and mitochondrial dynamics in osteoclast differentiation and function [PDF]

Os osteoclastos são macrófagos tecido-específicos com a função de reabsorção óssea. Por serem células gigantes e multinucleadas, os osteoclastos necessitam, desde a sua formação, passando pela adesão e movimentação na superfície óssea e finalmente pela ...
Venturini, Lucas Gabriel Rodrigues
core   +1 more source

Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A [PDF]

, 2020
Charcot-Marie-Tooth disease type 2A (CMT2A) is an untreatable childhood peripheral neuropathy caused by mutations of the mitochondrial fusion protein, mitofusin (MFN) 2.
Barbara Zablocka, Joshua N Ho, Franco, Antonietta, Gerald W Dorn, Timothy M Miller, Ho, Joshua N, Zablocka, Barbara, Robert H Baloh, Ly, Cindy, Miller, Timothy M, Yoo, Andrew S, Emily K Walton, Baloh, Robert H, Antonietta Franco, Dorn, Gerald W, Xiawei Dang, Michael E Shy, Cindy Ly, Shy, Michael E, Andrew S Yoo, Walton, Emily K, Dang, Xiawei   +21 more
core   +2 more sources

Function and regulation of mitofusin 2 in cardiovascular physiology and pathology

European Journal of Cell Biology, 2018
Mitochondrial dynamics with constant fusion and fission plays vital roles in regulating cellular biological processes. Mitofusin 2 (Mfn2) is dynamin-related protein whose activity promotes mitochondrial fusion and maintains the homeostasis of mitochondrial dynamics.
Fei Yu, Tao Xu, Man Wang, Wenguang Chang, Peifeng Li, Jianxun Wang   +5 more
openaire   +2 more sources

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

EARLY-ONSET STROKE ASSOCIATED WITH A MUTATION IN MITOFUSIN 2

Neurology, 2008
Mitofusin 2 ( MFN2 ) gene encodes an outer mitochondrial membrane protein which plays a central role in mitochondrial fusion.1 Mutations in the MFN2 gene have recently been reported to cause up to 33% of axonal peripheral neuropathies which in some cases involved the CNS.2,3 Since an initial study, which linked MFN2 mutations with Charcot-Marie-Tooth ...
K W, Chung, S Y, Cho, S J, Hwang, K H, Kim, J H, Yoo, O, Kwon, S M, Kim, I N, Sunwoo, S, Züchner, B O, Choi   +9 more
openaire   +3 more sources

Mitofusin 2 Is Essential for IP3-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes

Frontiers in Physiology, 2019
Aim: Endothelin-1 (ET-1) and angiotensin II (Ang II) are multifunctional peptide hormones that regulate the function of the cardiovascular and renal systems.
Lea K. Seidlmayer, Lea K. Seidlmayer, Christine Mages, Christine Mages, Annette Berbner, Petra Eder-Negrin, Paula Anahi Arias-Loza, Mathias Kaspar, Moshi Song, Gerald W. Dorn, Michael Kohlhaas, Stefan Frantz, Stefan Frantz, Christoph Maack, Brenda Gerull, Elena N. Dedkova, Elena N. Dedkova   +16 more
doaj   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Overexpression of mitofusin 2 in the diabetic heart; pathological or cardioprotective remodelling? [PDF]

, 2015
Background: Mitochondrial dysfunction is an established hallmark of diabetic cardiomyopathy (DCM). Mitofusin 2 (Mfn2) is widely believed to function as a molecular tether, binding mitochondria to the sarcoplasmic reticulum (SR) to form specialised Ca2 ...
Kitmitto, Ashraf, Cooper, Garth JS, Iqbal, Mohammad Monib, Bennett, Hayley, Murfitt, Lucy, Pinali, Christian; id_orcid, Cartwright, Elizabeth; id_orcid   +6 more
core   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source