Results 91 to 100 of about 12,377 (209)

Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases

Cells, 2020
Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids.
Sabina Cisa-Wieczorek, María Isabel Hernández-Alvarez   +1 more
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons

FASEB BioAdvances, 2020
Dynamic fission and fusion events regulate mitochondrial shape, distribution, and rejuvenation, and proper control of these processes is essential for neuronal homeostasis. Here, we report that Gas7, a known cytoskeleton regulator, controls mitochondrial
Jagannatham Naidu Bhupana, Bo‐Tsang Huang, Gunn‐Guang Liou, Marcus J. Calkins, Sue Lin‐Chao   +4 more
doaj   +1 more source

Role of Mitofusins and Mitophagy in Life or Death Decisions

Frontiers in Cell and Developmental Biology, 2020
Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy ...
Mariana Joaquim, Mafalda Escobar-Henriques   +1 more
doaj   +1 more source

Optimal timing to assess exercise‐induced oxidative stress: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract There is a lack of consensus on optimal timing to assess redox biomarkers post‐exercise, limiting methodological standardisation and linking oxidative stress to physiology. We determined optimal post‐exercise oxidative stress assessment times using three redox biomarkers: glutathione, F2‐isoprostanes and protein carbonyls.
Chrysovalantis Stachteas, Nikolaos Georgogiannis, George G. Nastos, Panagiotis N. Chatzinikolaou, Petros C. Dinas, Anastasios A. Theodorou, Vassilis Paschalis, Ioannis S. Vrabas, Antonios Kyparos, Athanasios Z. Jamurtas, Ioannis G. Fatouros, Michalis G. Nikolaidis, Nikos V. Margaritelis   +12 more
wiley   +1 more source

Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis [PDF]

, 2007
An inexorable loss of terminally differentiated heart muscle cells is a crucial causal factor for heart failure. Here, we have provided several lines of evidence to demonstrate that mitofusin-2 (Mfn-2; also called hyperplasia suppressor gene), a member ...
Shen, Tao, Kuang-Hueih Chen, Tang, Jian, Zheng, Ming, Jian Tang, Wanrui Zhang, Cao, Chunmei, Xiao, Rui-Ping, Heping Cheng, Ming Zheng, Tao Shen, Chen, Kuang-Hueih, Chunmei Cao, Chen, Chunlei, Zhang, Wanrui, Rui-Ping Xiao, Cheng, Heping, Chunlei Chen   +17 more
core   +1 more source

Role of mitofusin 2 (Mfn2) in controlling cellular proliferation

The FASEB Journal, 2013
It has been reported that Mitofusin2 (Mfn2) inhibits cell proliferation when overexpressed. We wanted to study the role of endogenous Mfn2 in cell proliferation, along with the structural features of Mfn2 that influence its mitochondrial localization and control of cell proliferation. Mfn2‐knockdown clones of a B‐cell lymphoma cell
Kuang-Hueih, Chen, Asish, Dasgupta, Jinhui, Ding, Fred E, Indig, Paritosh, Ghosh, Dan L, Longo   +5 more
openaire   +3 more sources

MFN2-a multifaceted guardian against Parkinson’s pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress

Frontiers in Aging Neuroscience
BackgroundParkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide and its exact pathogenesis remains unclear. This study aims to comprehensively explore the role of MFN2 in PD based on in vivo and in vitro models for ...
Yan Cheng, Hongjiang Zhai, Yong Liu, Yunzhou Yang, Bo Fang, Mingxiang Song, Xiuqin Wang, Ping Zhong   +7 more
doaj   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

“In vitro” capacitation and subsequent acrosome reaction are related to changes in the expression and location of midpiece actin and mitofusin-2 in boar spermatozoa [PDF]

, 2012
The induction of “in vitro” capacitation (IVC) and subsequent, progesterone-induced “in vitro” acrosome reaction (IVAR) was concomitant with an increase in actin polymerization, also showing an increase in actin presence at the apical area of the ...
J. M. Fernández Novell, A. Peña, J. E. Rodríguez Gil, L. Ramió Lluch, T. Rigau, BUCCI, DIEGO   +5 more
core   +1 more source