Results 91 to 100 of about 17,474 (245)
Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION. [PDF]
, 2016 The relevance of mitochondrial phosphate carrier (PiC), encoded by SLC25A3, in bioenergetics is well accepted. However, little is known about the mechanisms mediating the cellular impairments induced by pathological SLC25A3 variants.
Acoba, Michelle G. +9 more
core +2 more sources
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution [PDF]
, 2018 Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors.
Bova, Sergio +5 more
core +5 more sources
Biomedicines, 2022 Pulmonary hypertension (PH) is a severe progressive disease, and the uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) is one of the main causes.
I-Chen Chen +9 more
doaj +1 more source
Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications
Barrier Immunity, EarlyView.A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu +9 more
wiley +1 more source
Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion [PDF]
, 2006 Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact ...
Chan, David C., Griffin, Erik E.
core +3 more sources
Function and regulation of mitofusin 2 in cardiovascular physiology and pathology
European Journal of Cell Biology, 2018 Mitochondrial dynamics with constant fusion and fission plays vital roles in regulating cellular biological processes. Mitofusin 2 (Mfn2) is dynamin-related protein whose activity promotes mitochondrial fusion and maintains the homeostasis of mitochondrial dynamics.
Fei Yu +5 more
openaire +2 more sources
Advanced ScienceNeuroinflammation is associated with poor outcomes in patients with spinal cord injury (SCI). Recent studies have demonstrated that stimulator of interferon genes (Sting) plays a key role in inflammatory diseases.
Fei‐Long Wei +12 more
doaj +1 more source
Pathological classification of equine recurrent laryngeal neuropathy [PDF]
, 2018 Recurrent Laryngeal Neuropathy (RLN) is a highly prevalent and predominantly left‐sided, degenerative disorder of the recurrent laryngeal nerves (RLn) of tall horses, that causes inspiratory stridor at exercise because of intrinsic laryngeal muscle ...
Draper, A C E, Piercy, R J
core +2 more sources
Infectious Agents and Cancer, 2018 Objective To investigate the expression of Mitofusin-2 (MFN2) in HCC tissues and its role in the development of HCC. Methods A total of 107 HCC specimens were collected for tissue microarray analysis and immunohistochemistry (IHC) analysis.
Xiumei Wang +7 more
doaj +1 more source