Results 111 to 120 of about 12,377 (209)
The Journal of Physiology, EarlyView.Abstract figure legend To investigate the role of glucose availability in fetal left ventricle (LV) development, this study assessed whether maternal late gestation undernutrition (LGUN; 50% of Control diet) induced alterations in the contractility, metabolic, and hormonal profile can be ameliorated in LGUN fetuses receiving glucose infusion (LGUN+G ...
Melanie R. Bertossa +10 more
wiley +1 more source
Effect of mitofusin 1 and mitofusin 2 deficiency on electrophysiology parameter following stimulated ischemia reperfusion [PDF]
, 2020 Master of ...
openaire +2 more sources
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications
Redox Biology, 2017 Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is
Susana Rovira-Llopis +5 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
Loss of Mfn1 but not Mfn2 enhances adipogenesis.
PLoS ONEObjectiveA biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte differentiation, growth and/or ...
Jake P Mann +15 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana +2 more
wiley +1 more source
Mutation screening of mitofusin 2 in Charcot-Marie-Tooth disease type 2 [PDF]
, 2011 Charcot-Marie-Tooth (CMT) disease is among the most common inherited neurological disorders. Mutations in the gene mitofusin 2 ( MFN2 ) cause the axonal subtype CMT2A, which has also been shown to be associated with optic atrophy, clinical signs of first
Melanson, Michel +19 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A high‐fat, high‐sucrose diet (HFHSD) exacerbated muscle and metabolic dysregulation in mdx mice while also altering the physiological response to prednisolone (Pred) In diaphragms of control diet (CD)‐fed mdx mice, prednisolone treatment improved muscle function and reduced fibrosis, inflammatory signalling, and mitochondrial ...
Morgan E. Vorwald +5 more
wiley +1 more source
New trick for an old dog - Mitofusin controls peroxisomal dynamics in stem cells [PDF]
, 2023 Adult stem cells make up an important reservoir of progenitor cells capable regenerating tissues and organs throughout lifetime. Several signaling pathways have been characterized to influence the decision stem cells make between self-renewing (i.e ...
Kumar, Tanushree +3 more
core
SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
The Journal of Physiology, EarlyView.Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source