Results 131 to 140 of about 12,377 (209)

A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Aging Cell, Volume 25, Issue 7, July 2026.
Aging‐associated MLKL upregulation in hepatocytes induces mitochondrial dysfunction and oxidative stress, accompanied by increased release of pro‐inflammatory extracellular vesicles. These changes are associated with increased p16+/p21+ senescence in hepatocytes and non‐parenchymal cells (macrophages, stellate cells, and endothelial cells), suggesting ...
Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene‐Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany Hannafon, Courtney Houchen, Jonathan D. Wren, Andriy Yabluchanskiy, Veronica Galvan, Nagib Ahsan, Michael Kinter, Tommy L. Lewis Jr, Sathyaseelan S. Deepa   +21 more
wiley   +1 more source

Metabolic Kinases as Regulators of Inter‐Organelle Communication in Aging and Age‐Related Diseases

Aging Cell, Volume 25, Issue 7, July 2026.
Metabolic kinases integrate cellular energy, nutrient, and stress signals to regulate inter‐organelle coordination during aging. In young or healthy cells, coordinated communication among mitochondria, the endoplasmic reticulum, lysosomes, peroxisomes, and the Golgi apparatus supports calcium handling, lipid metabolism, mitochondrial dynamics ...
Md Riad Chowdhury, Jae‐Han Jeon, Dipanjan Chanda   +2 more
wiley   +1 more source

The Role of Mammalian Mitofusin-2 (Mfn-2) in Lipid Metabolism [PDF]

, 2017
The architecture of mitochondria is closely associated with numerous functions for cell signaling, growth and senescence. The overall phenomenon of mitochondrial dynamics, which include fusion and fission events, characterizes the fundamental mechanism ...
Ambilwade, Prashant of 1984-
core  

Lidamycin induces mitophagy in pancreatic cancer cells by regulating the expression of Mfn2

Scientific Reports
Lidamycin (LDM) has been confirmed to have a strong anti-pancreatic cancer effect and can affect the mitochondrial function of pancreatic cancer cells. Mitofusin-2 (Mfn2) is located in the outer membrane of mitochondria, and Mfn2 is currently believed to
Boya Wu, Bing Qi, Liumeng Duan, Jing Chen   +3 more
doaj   +1 more source

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function [PDF]

The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with social competitiveness, and the mitochondrial fusion protein mitofusin 2 (Mfn2) in NAc ...
Guillot de Suduiraut, Marie-Isabelle, Gebara, Elias Georges, Zorzano, Antonio, Astori, Simone, Grosse, Jocelyn, Sandi, Carmen, Schneider, Bernard, Ghosal, Sriparna, Chioino, Alessandro, Zanoletti, Olivia, Ramos Fernandez, Eva   +10 more
core   +1 more source

Mitofusin-2 [PDF]

, 2020
openaire   +1 more source

Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells. [PDF]

Int J Mol Sci, 2023
Yegambaram M, Sun X, Flores AG, Lu Q, Soto J, Richards J, Aggarwal S, Wang T, Gu H, Fineman JR, Black SM.   +10 more
europepmc   +1 more source

A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle. [PDF]

J Clin Invest, 2022
Wang X, Jia Y, Zhao J, Lesner NP, Menezes CJ, Shelton SD, Venigalla SSK, Xu J, Cai C, Mishra P.   +9 more
europepmc   +1 more source

High-fat diet causes mitochondrial damage and downregulation of mitofusin-2 and optic atrophy-1 in multiple organs. [PDF]

J Clin Biochem Nutr, 2023
Zheng P, Ma W, Gu Y, Wu H, Bian Z, Liu N, Yang D, Chen X.   +7 more
europepmc   +1 more source

Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells. [PDF]

Elife, 2023
Wang Y, Troughton LD, Xu F, Chatterjee A, Ding C, Zhao H, Pulido Cifuentes L, Wagner RB, Wang T, Tan S, Chen J, Li L, Umulis D, Kuang S, Suter DM, Yuan C, Chan D, Huang F, Oakes PW, Deng Q.   +19 more
europepmc   +1 more source