Results 101 to 110 of about 17,474 (245)
EARLY-ONSET STROKE ASSOCIATED WITH A MUTATION IN MITOFUSIN 2
Neurology, 2008 Mitofusin 2 ( MFN2 ) gene encodes an outer mitochondrial membrane protein which plays a central role in mitochondrial fusion.1 Mutations in the MFN2 gene have recently been reported to cause up to 33% of axonal peripheral neuropathies which in some cases involved the CNS.2,3 Since an initial study, which linked MFN2 mutations with Charcot-Marie-Tooth ...
K W, Chung +9 more
openaire +3 more sources
Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. [PDF]
, 2014 The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens.
Anastas, Sara +9 more
core +3 more sources
Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight
Cell Reports, 2019 Summary: We found that exposure of adult animals to calorie-dense foods rapidly abolished expression of mitofusin 2 (Mfn2), a gene promoting mitochondrial fusion and mitochondrion-endoplasmic reticulum interactions, in white and brown fat.
Giacomo Mancini +5 more
doaj +1 more source
Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes [PDF]
, 2016 The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions.
Nakatsuka, Atsuko, Wada, Jun
core +1 more source
The Journal of Pathology, EarlyView.Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song +6 more
wiley +1 more source
Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases
Cells, 2020 Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids.
Sabina Cisa-Wieczorek +1 more
doaj +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo +3 more
wiley +1 more source
Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons
FASEB BioAdvances, 2020 Dynamic fission and fusion events regulate mitochondrial shape, distribution, and rejuvenation, and proper control of these processes is essential for neuronal homeostasis. Here, we report that Gas7, a known cytoskeleton regulator, controls mitochondrial
Jagannatham Naidu Bhupana +4 more
doaj +1 more source
Role of Mitofusins and Mitophagy in Life or Death Decisions
Frontiers in Cell and Developmental Biology, 2020 Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy ...
Mariana Joaquim +1 more
doaj +1 more source
Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging
Cancer Science, EarlyView.Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka +4 more
wiley +1 more source