Results 101 to 110 of about 24,584,287 (169)
Lidamycin induces mitophagy in pancreatic cancer cells by regulating the expression of Mfn2
Scientific ReportsLidamycin (LDM) has been confirmed to have a strong anti-pancreatic cancer effect and can affect the mitochondrial function of pancreatic cancer cells. Mitofusin-2 (Mfn2) is located in the outer membrane of mitochondria, and Mfn2 is currently believed to
Boya Wu +3 more
doaj +1 more source
Journal of Pain ResearchShuangcheng Yu,1,* Wei Huang,2,* Haiqing Su,2 Fangyan Jiang31Department of Radiology, Affiliated Minzu Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Medical ...
Yu S, Huang W, Su H, Jiang F
doaj
Overexpression of mitofusin 2 in the diabetic heart; pathological or cardioprotective remodelling?
, 2015 Background: Mitochondrial dysfunction is an established hallmark of diabetic cardiomyopathy (DCM). Mitofusin 2 (Mfn2) is widely believed to function as a molecular tether, binding mitochondria to the sarcoplasmic reticulum (SR) to form specialised Ca2 ...
Kitmitto, Ashraf +6 more
core +1 more source
Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis
, 2007 An inexorable loss of terminally differentiated heart muscle cells is a crucial causal factor for heart failure. Here, we have provided several lines of evidence to demonstrate that mitofusin-2 (Mfn-2; also called hyperplasia suppressor gene), a member ...
Shen, Tao +17 more
core +1 more source
Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A [PDF]
, 2017 Charcot-Marie-Tooth disease type 2A is an autosomal dominant axonal form of peripheral neuropathy caused by mutations in the mitofusin 2 gene. Mitofusin 2 encodes a mitochondrial outer membrane protein that participates in mitochondrial fusion in ...
Courvoisier, Delphine S. +6 more
core
, 2012 The induction of “in vitro” capacitation (IVC) and subsequent, progesterone-induced “in vitro” acrosome reaction (IVAR) was concomitant with an increase in actin polymerization, also showing an increase in actin presence at the apical area of the ...
J. M. Fernández Novell +5 more
core +1 more source
Mitofusin-2 Expression Is Implicated in Cervical Cancer Pathogenesis
, 2018 BACKGROUND/AIM: It remains unclear whether mitofusin-2 (MFN2) functions as a tumour suppressor or oncogene in cancer progression. In this study we, therefore, aimed to investigate the effect of MFN2 on the pathogenesis of cervical cancer.
현영민, 장향란, 안성용
core +1 more source
The Role of Mammalian Mitofusin-2 (Mfn-2) in Lipid Metabolism [PDF]
, 2017 The architecture of mitochondria is closely associated with numerous functions for cell signaling, growth and senescence. The overall phenomenon of mitochondrial dynamics, which include fusion and fission events, characterizes the fundamental mechanism ...
Ambilwade, Prashant of 1984-
core
Prognostic impact of mitofusin 2 expression in colon cancer. [PDF]
Transl Cancer Res, 2022 Cheng X, Li Y, Liu F.
europepmc +1 more source
Zebrafish mitofusin-2 knockdown: a new model for CMT2A neuropathy?
, 2009 Mitofusin 2 (MFN2) is a large dynamin-like GTPase protein, located in the outer membrane of mitochondria and at the surface of the endoplasmic reticulum.
VETTORI, ANDREA +7 more
core