Results 71 to 80 of about 12,758 (225)
New trick for an old dog - Mitofusin controls peroxisomal dynamics in stem cells [PDF]
, 2023 Adult stem cells make up an important reservoir of progenitor cells capable regenerating tissues and organs throughout lifetime. Several signaling pathways have been characterized to influence the decision stem cells make between self-renewing (i.e ...
Kumar, Tanushree +3 more
core
Advanced Science, EarlyView.Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen +13 more
wiley +1 more source
Mitofusin 2 Builds a Bridge between ER and Mitochondria [PDF]
, 2008 Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2—tethering
Merkwirth, Carsten +3 more
core +1 more source
Regulating a uniter: control of mitofusin 2 expression [PDF]
Cardiovascular Research, 2012 This editorial refers to ‘The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells’ by E. Sorianello et al. , pp. 38–47, this issue. Sorianello et al. 1 provide important new information on the regulation on mitofusin (Mfn)2 expression.
Anne A, Knowlton, Le, Chen
openaire +2 more sources
Journal of the Peripheral Nervous System, 2023 AbstractBackground and aimsMitofusin 1 (MFN1) and MFN2 are outer mitochondrial membrane fusogenic proteins regulating mitochondrial network morphology. MFN2 mutations cause Charcot‐Marie‐Tooth type 2A (CMT2A), an axonal neuropathy characterized by mitochondrial fusion defects, which in the case of a GTPase domain mutant, were rescued following wild ...
Filippos Stavropoulos +6 more
openaire +2 more sources
eLife, 2014 Mitochondrial fusion and fission affect the distribution and quality control of mitochondria. We show that Marf (Mitochondrial associated regulatory factor), is required for mitochondrial fusion and transport in long axons.
Hector Sandoval +14 more
doaj +1 more source
Atmosphere, 2022 Dermal exposure to nicotine is common due to the widespread use of tobacco products. Here, we assessed the effects of nicotine at concentrations found in thirdhand smoke (THS) contaminated environments and electronic cigarette (EC) spills or leaks on a ...
Giovanna L. Pozuelos +7 more
doaj +1 more source
Advanced Science, EarlyView.Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu +8 more
wiley +1 more source
Mitochondrial fusion is required for spermatogonial differentiation and meiosis
eLife, 2019 Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Grigor Varuzhanyan +6 more
doaj +1 more source
Mitochonic acid 5 regulates mitofusin 2 to protect microglia
Neural Regeneration Research, 2021 Microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis.
Jian Tan +7 more
doaj +1 more source