Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion [PDF]
Scientific Reports, 2022 Mitochondrial dysfunction induced by acute cardiac ischemia–reperfusion (IR), may increase susceptibility to arrhythmias by perturbing energetics, oxidative stress production and calcium homeostasis. Although changes in mitochondrial morphology are known
Xiu-Yi Kwek +17 more
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Recent insights into the structure and function of Mitofusins in mitochondrial fusion [version 1; referees: 2 approved] [PDF]
F1000Research, 2018 Mitochondria undergo frequent fusion and fission events to adapt their morphology to cellular needs. Homotypic docking and fusion of outer mitochondrial membranes are controlled by Mitofusins, a set of large membrane-anchored GTPase proteins belonging to
Mickael M Cohen, David Tareste
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Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases [PDF]
Frontiers in Physiology, 2019 Mitochondria are dynamic organelles engaged in quality control and aging processes. They constantly undergo fusion, fission, transport, and anchoring events, which empower mitochondria with a very interactive behavior.
Mafalda Escobar-Henriques +1 more
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Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. [PDF]
PLoS Pathogens, 2015 Mitochondria are highly dynamic subcellular organelles participating in many signaling pathways such as antiviral innate immunity and cell death cascades. Here we found that mitochondrial fusion was impaired in dengue virus (DENV) infected cells.
Chia-Yi Yu +8 more
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Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery
Cells, 2020 Mitochondrial fusion and fission tailors the mitochondrial shape to changes in cellular homeostasis. Players of this process are the mitofusins, which regulate fusion of the outer mitochondrial membrane, and the fission protein DRP1.
Christina Wolf +7 more
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Protein & Cell, 2017 Hypertonia is a neurological dysfunction associated with a number of central nervous system disorders, including cerebral palsy, Parkinson’s disease, dystonia, and epilepsy.
Crystal A. Lee, Lih-Shen Chin, Lian Li
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Mitochondrial fusion is required for spermatogonial differentiation and meiosis [PDF]
eLife, 2019 Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Grigor Varuzhanyan +6 more
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Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated beta-Cell Connectivity and Insulin Secretion [PDF]
, 2022 Only Vanderbilt University affiliated authors are listed on VUIR. For a full list of authors, access the version of record at https://diabetesjournals.org/diabetes/article/71/7/1472/145040/Mitofusins-Mfn1-and-Mfn2-Are-Required-to-PreserveMitochondrial ...
Xu, Yanwen, Gu, Guoqiang
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A human mitofusin 2 mutation can cause mitophagic cardiomyopathy
eLife, 2023 Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15–20× over-represented in
Antonietta Franco +12 more
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Role of Mitofusins and Mitophagy in Life or Death Decisions
Frontiers in Cell and Developmental Biology, 2020 Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy ...
Mariana Joaquim +1 more
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