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Mitochondrial Membrane Dynamics—Functional Positioning of OPA1
Antioxidants, 2018 The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion.
Hakjoo Lee, Yisang Yoon
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OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions [PDF]
Cell Reports, 2017 Summary: OPA1 is a GTPase that controls mitochondrial fusion, cristae integrity, and mtDNA maintenance. In humans, eight isoforms are expressed as combinations of long and short forms, but it is unclear whether OPA1 functions are associated with specific
Sara Vidoni, David C Chan, Claudia Zanna
exaly +4 more sources
OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling [PDF]
Frontiers in Cell and Developmental Biology, 2022 Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cristae ...
Benjamín Cartes-Saavedra +11 more
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Redox Biology, 2021 Background: Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are linked to several mitochondrial alterations. Cigarette smoke (CS) alters the structure and function of mitochondria.
Isaac K Sundar, Irfan Rahman
exaly +3 more sources
Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity
Frontiers in Bioscience-Landmark, 2022 Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China.
Jinling Wang +6 more
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Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat
Disease Models & Mechanisms, 2022 Impaired thermogenesis observed in mice with whole-body ablation of peroxisome proliferator-activated receptor-γ coactivator-1β (PGC-1β; officially known as PPARGC1B) may result from impaired brown fat (brown adipose tissue; BAT) function, but other ...
Jiří Funda +10 more
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OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation
Mitochondrial Communications, 2023 Optic Atrophy 1 (OPA1), a mitochondrial inner protein, is involved in both mitochondrial fusion dynamic and cell apoptosis. OPA1 Exon4b (OPA1-Exon4b) was reported to be downregulated in hepatocellular carcinoma (HCC).
Haite Tang +7 more
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Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth
Cells, 2020 Metabolic reprogramming universally occurs in cancer. Mitochondria act as the hubs of bioenergetics and metabolism. The morphodynamics of mitochondria, comprised of fusion and fission processes, are closely associated with mitochondrial functions and are
Meng Li +15 more
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Opa1 Prevents Apoptosis and Cisplatin-Induced Ototoxicity in Murine Cochleae
Frontiers in Cell and Developmental Biology, 2021 Optic atrophy1 (OPA1) is crucial for inner mitochondrial membrane (IMM) fusion and essential for maintaining crista structure and mitochondrial morphology.
Tingting Dong +9 more
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Nature Communications, 2023 Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a role in cristae shaping.
Hakjoo Lee +9 more
doaj +1 more source