Results 1 to 10 of about 25,822 (292)

Mitochondrial Membrane Dynamics—Functional Positioning of OPA1 [PDF]

Antioxidants, 2018
The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion.
Hakjoo Lee, Yisang Yoon
exaly   +5 more sources

The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury

Nature Communications, 2023
Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a role in cristae shaping.
Hakjoo Lee, Tae Jin Lee, Chad A. Galloway, Wenbo Zhi, Wei Xiao, Karen L. de Mesy Bentley, Ashok Sharma, Yong Teng, Hiromi Sesaki, Yisang Yoon   +9 more
doaj   +2 more sources

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

The EMBO Journal
Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms in the mitochondrion, a membrane-anchored long form (l ...
Michelle Y Fry, Paula P Navarro, Pusparanee Hakim, Virly Y Ananda, Xingping Qin, Juan C Landoni, Sneha Rath, Zintis Inde, Camila Makhlouta Lugo, Bridget E Luce, Yifan Ge, Julie L McDonald, Ilzat Ali, Leillani L Ha, Benjamin P Kleinstiver, David C Chan, Kristopher A Sarosiek, Luke H Chao   +17 more
doaj   +2 more sources

OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation [PDF]

Brain, 2015
Hearing impairment is the second most prevalent clinical feature after optic atrophy in Dominant Optic Atrophy associated with mutations in the OPA1 gene.
Rosamaria Santarelli, Pietro Scimemi, Elona Cama   +2 more
exaly   +5 more sources

OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance OPA1 mediates inner mitochondrial membrane dynamic reshaping, and mutations affecting this protein cause autosomal dominant optic atrophy (ADOA), a leading cause of inherited blindness.
Benjamín Cartes-Saavedra, Daniel Lagos, Josefa Macuada   +2 more
exaly   +2 more sources

Metastatic breast cancer cells are selectively dependent on the mitochondrial cristae-shaping protein OPA1

Cell Death and Disease
In breast cancer, the inner mitochondrial membrane fusion protein Optic Atrophy 1 (OPA1) is upregulated and its inhibition reverses acquired chemoresistance. However, it remains unclear whether OPA1 inhibition also targets normal breast cells.
Antigoni Diokmetzidou, Aurora Maracani, Anna Pellattiero, Mauricio Cardenas-Rodriguez, Erwan A. Rivière, Luca Scorrano   +5 more
doaj   +2 more sources

Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD

Redox Biology, 2021
Background: Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are linked to several mitochondrial alterations. Cigarette smoke (CS) alters the structure and function of mitochondria.
Krishna Prahlad Maremanda, Isaac K Sundar, Irfan Rahman   +2 more
exaly   +3 more sources

Integrated bioinformatic and in vivo analysis confirms the cardioprotective role of OPA1 [PDF]

BMC Cardiovascular Disorders
Background OPA1 is an inner mitochondrial membrane protein that mediates diverse signaling processes. OPA1 is important for cardiac function and protects against cardiac insults such as ischemia/reperfusion injury.
Claire Fong-McMaster, Serena M. Pulente, Luke S. Kennedy, Tyler K.T. Smith, Stephanie Myers, Michel N. Kanaan, Charbel Y. Karam, Matthew Cope, Michelle M. Levesque, Ella McIlroy, Ilka Lorenzen-Schmidt, Craig J. Goergen, Morgan D. Fullerton, Miroslava Cuperlovic-Culf, Erin E. Mulvihill, Mary-Ellen Harper   +15 more
doaj   +2 more sources

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1. [PDF]

Nat Commun
Cardiolipin (CL) is a mitochondria-specific phospholipid that forms heterotypic interactions with membrane-shaping proteins and regulates the dynamic remodeling and function of mitochondria.
Thatavarthy S, Abriata LA, Meireles FTP, Zuccaro KE, Gargey Iragavarapu A, Sullivan GM, Moss FR, Frost A, Dal Peraro M, Aydin H.   +9 more
europepmc   +2 more sources

The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice

Nature Communications
Recent studies have highlighted the importance of mitochondria in NP cells and articular chondrocyte health. Since the understanding of mechanisms governing mitochondrial dynamics in these tissues is lacking, we investigated the role of OPA1, a ...
Vedavathi Madhu, Miriam Hernandaz-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige K. Boneski, Hiromi Sesaki, Ruteja A. Barve, John A. Collins, Makarand V. Risbud   +10 more
doaj   +3 more sources