Results 1 to 10 of about 10,760 (112)

Nitrite increases mitofusin-1 levels to inhibit vascular smooth muscle cell proliferation and prevent intimal hyperplasia [PDF]

Redox Biology
Vascular disease remains a leading cause of morbidity and mortality and is driven by maladaptive vascular remodeling following injury. Stent-induced vascular injury induces vascular smooth muscle cell (VSMC) phenotypic switching from a contractile to a ...
Wenxi An, Christopher Reyes, Cristina Espinosa-Diez, Parth Patel, Danielle Guimaraes, Francisco Villareal, Morgan Jessup, Claudette St Croix, Delphine Gomez, Krithika Rao, Sruti Shiva   +10 more
doaj   +2 more sources

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth

Cells, 2020
Metabolic reprogramming universally occurs in cancer. Mitochondria act as the hubs of bioenergetics and metabolism. The morphodynamics of mitochondria, comprised of fusion and fission processes, are closely associated with mitochondrial functions and are
Maikel P Peppelenbosch, Monique M A Verstegen, Qiuwei Pan   +2 more
exaly   +3 more sources

Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells [PDF]

Frontiers in Cell and Developmental Biology
Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these include elongated mitochondria in the inner segments and a distinct ...
Michael Landowski, Michael Landowski, Ryo Hagimori, Ryo Hagimori, Purnima Gogoi, Purnima Gogoi, Pawan K. Shahi, Pawan K. Shahi, Kazuya Oikawa, Kazuya Oikawa, Kazuya Oikawa, Vijesh J. Bhute, Vijesh J. Bhute, Gillian J. McLellan, Gillian J. McLellan, Gillian J. McLellan, Sakae Ikeda, Sakae Ikeda, Ken-ichi Yamada, Bikash R. Pattnaik, Bikash R. Pattnaik, Bikash R. Pattnaik, Tetsuya Takimoto, Akihiro Ikeda, Akihiro Ikeda   +24 more
doaj   +2 more sources

A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: Implications for cellular health and diseases

Saudi Pharmaceutical Journal
The mitochondria are responsible for the production of cellular ATP, the regulation of cytosolic calcium levels, and the organization of numerous apoptotic proteins through the release of cofactors necessary for the activation of caspases.
Adel Alghamdi
exaly   +3 more sources

Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis [PDF]

Cell Death and Disease
Cartilage degradation is considered a hallmark of end-stage osteoarthritis (OA), characterized by significant alterations in the extracellular matrix (ECM).
Bo Liu, Yun Liang, Chenzhong Wang, Ziyu Weng, Yi Yang, Yi Shi, Chi Zhang   +6 more
doaj   +2 more sources

Pathogenic roles of the IMNEPD-associated PTRH2 mutants in aggravating mitochondrial dynamics and its rescue [PDF]

Molecular Medicine
Background Mitochondrial dynamics, orchestrated by a finely tuned balance between fusion and fission, are critical for cellular homeostasis and development.
DoHyeong Na, Seungmin Yoo, Muhah Jeong, Nahyun Lee, Youngwon Kim, Youbin Kim, Dong-Hyung Cho, Yong-Keun Jung   +7 more
doaj   +2 more sources

KDM6B induces demethylation of H3K27me3 in MFN1 to modulate aberrant mitophagy in sepsis-induced acute lung injury [PDF]

Scientific Reports
Acute lung injury (ALI) commonly occurs as a complication of sepsis, significantly increasing mortality rates in septic patients. Macrophages play a critical role in sepsis pathogenesis.
Haoran Deng, Shiping Zhu, Xue Song, Yufei Guo, Xuchun Ding   +4 more
doaj   +2 more sources

Role of GTPase-Dependent Mitochondrial Dynamins in Heart Diseases

Frontiers in Cardiovascular Medicine, 2021
Heart function maintenance requires a large amount of energy, which is supplied by the mitochondria. In addition to providing energy to cardiomyocytes, mitochondria also play an important role in maintaining cell function and homeostasis.
Jiangen Liu, Xianjing Song, Youyou Yan, Bin Liu   +3 more
doaj   +1 more source

Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity

Frontiers in Bioscience-Landmark, 2022
Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China.
Jinling Wang, Xiufu Lin, Ningning Zhao, Guanping Dong, Wei Wu, Ke Huang, Junfen Fu   +6 more
doaj   +1 more source

Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy

Scientific Reports, 2021
Prognosis of severe heart failure remains poor. Urgent new therapies are required. Some heart failure patients do not respond to established multidisciplinary treatment and are classified as “non-responders”.
Yung Ting Hsiao, Ippei Shimizu, Takayuki Wakasugi, Yohko Yoshida, Ryutaro Ikegami, Yuka Hayashi, Masayoshi Suda, Goro Katsuumi, Masaaki Nakao, Takuya Ozawa, Daisuke Izumi, Takeshi Kashimura, Kazuyuki Ozaki, Tomoyoshi Soga, Tohru Minamino   +14 more
doaj   +1 more source