Results 1 to 10 of about 11,082 (189)

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth [PDF]

Cells, 2020
Metabolic reprogramming universally occurs in cancer. Mitochondria act as the hubs of bioenergetics and metabolism. The morphodynamics of mitochondria, comprised of fusion and fission processes, are closely associated with mitochondrial functions and are
Meng Li, Ruby Lieshout, Buyun Ma
exaly   +7 more sources

Chronic stress-induced downregulation of MFN1 contributes to fatty liver in chickens [PDF]

Frontiers in Veterinary Science
BackgroundChronic stress is a major contributor to Fatty Liver Syndrome (FLS) in fast-growing broilers, leading to physiological dysfunctions that compromise growth and immune response.
Ke Zhang, Hui Yu, Huimin Chen, Ziting Guan, Xiaoyu Wang, Jie Liu, Mindie Zhao, Ruqian Zhao, Ruqian Zhao, Dancheng Yang, Lei Wu   +10 more
doaj   +6 more sources

STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion [PDF]

Frontiers in Cell and Developmental Biology, 2021
Ferroptosis is a type of iron-dependent regulated cell death caused by the disruption that occurs when oxidative stress and antioxidant defenses interact, and then driven by lipid peroxidation and subsequent plasma membrane ruptures.
Changfeng Li, Jiao Liu, Wen Hou
exaly   +5 more sources

Nitrite increases mitofusin-1 levels to inhibit vascular smooth muscle cell proliferation and prevent intimal hyperplasia [PDF]

Redox Biology
Vascular disease remains a leading cause of morbidity and mortality and is driven by maladaptive vascular remodeling following injury. Stent-induced vascular injury induces vascular smooth muscle cell (VSMC) phenotypic switching from a contractile to a ...
Wenxi An, Christopher Reyes, Cristina Espinosa-Diez, Parth Patel, Danielle Guimaraes, Francisco Villareal, Morgan Jessup, Claudette St Croix, Delphine Gomez, Krithika Rao, Sruti Shiva   +10 more
doaj   +2 more sources

Mitofusin 1 in mitochondrial quality control and anti-inflammatory responses in nucleus pulposus cells during disc degeneration [PDF]

Scientific Reports
Mitochondrial dysfunction drives intervertebral disc degeneration, and mitochondrial dynamics are regulated by mitofusins (MFNs). In this study, we evaluated the roles of MFN1 and MFN2 in mitochondrial quality control and their responses to inflammation ...
Jae Won Shin, Young Mi Kang, Hak Sun Kim, Seong Hwan Moon, Kyung Soo Suk, Si Young Park, Byung Ho Lee, Ji Won Kwon   +7 more
doaj   +2 more sources

Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells [PDF]

Frontiers in Cell and Developmental Biology
Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these include elongated mitochondria in the inner segments and a distinct ...
Michael Landowski, Michael Landowski, Ryo Hagimori, Ryo Hagimori, Purnima Gogoi, Purnima Gogoi, Pawan K. Shahi, Pawan K. Shahi, Kazuya Oikawa, Kazuya Oikawa, Kazuya Oikawa, Vijesh J. Bhute, Vijesh J. Bhute, Gillian J. McLellan, Gillian J. McLellan, Gillian J. McLellan, Sakae Ikeda, Sakae Ikeda, Ken-ichi Yamada, Bikash R. Pattnaik, Bikash R. Pattnaik, Bikash R. Pattnaik, Tetsuya Takimoto, Akihiro Ikeda, Akihiro Ikeda   +24 more
doaj   +2 more sources

Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis [PDF]

Cell Death and Disease
Cartilage degradation is considered a hallmark of end-stage osteoarthritis (OA), characterized by significant alterations in the extracellular matrix (ECM).
Bo Liu, Yun Liang, Chenzhong Wang, Ziyu Weng, Yi Yang, Yi Shi, Chi Zhang   +6 more
doaj   +2 more sources

KDM6B induces demethylation of H3K27me3 in MFN1 to modulate aberrant mitophagy in sepsis-induced acute lung injury [PDF]

Scientific Reports
Acute lung injury (ALI) commonly occurs as a complication of sepsis, significantly increasing mortality rates in septic patients. Macrophages play a critical role in sepsis pathogenesis.
Haoran Deng, Shiping Zhu, Xue Song, Yufei Guo, Xuchun Ding   +4 more
doaj   +2 more sources

Baicalin inhibits infectious bronchitis virus replication via MAVS-dependent interferon-β upregulation and mitochondrial function preservation [PDF]

Scientific Reports
The inhibitory effect of baicalin on infectious bronchitis virus (IBV) replication is closely related to expression of the mitochondrial antiviral signaling protein (MAVS) in chicken embryonic kidney (CEK) cells.
Jiongjie He, Huilin Guo, Ling Wang, Shengyi Wang   +3 more
doaj   +2 more sources

Pathogenic roles of the IMNEPD-associated PTRH2 mutants in aggravating mitochondrial dynamics and its rescue [PDF]

Molecular Medicine
Background Mitochondrial dynamics, orchestrated by a finely tuned balance between fusion and fission, are critical for cellular homeostasis and development.
DoHyeong Na, Seungmin Yoo, Muhah Jeong, Nahyun Lee, Youngwon Kim, Youbin Kim, Dong-Hyung Cho, Yong-Keun Jung   +7 more
doaj   +2 more sources