Results 41 to 50 of about 11,908 (171)

Mitofusin1 in oocyte is essential for female fertility

Redox Biology, 2019
Mitofusins (Mfn) are the important regulators of mitochondrial organization in mammalian cells; however, their roles during oocyte development remain unknown.
Xiaojing Hou, Shuai Zhu, Hao Zhang, Chunling Li, Danhong Qiu, Juan Ge, Xuejiang Guo, Qiang Wang   +7 more
doaj   +1 more source

Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

Cell Reports, 2020
Summary: Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play a major role in inflammation, we studied the contribution of Mfn2 to the ...
Juan Tur, Selma Pereira-Lopes, Tania Vico, Eros A. Marín, Juan P. Muñoz, Maribel Hernández-Alvarez, Pere-Joan Cardona, Antonio Zorzano, Jorge Lloberas, Antonio Celada   +9 more
doaj   +1 more source

MFN1 is involved in antiviral signaling.

, 2013
A, Schematic representation of the MFN1 domain. B, L929 cells were transfected with a virus-responsive reporter gene (p-125 Luc) and either an empty vector (Empty), an expression vector for MFN1, or an expression vector for MFN2 as indicated.
Shiori Takamatsu (107244), Hideo Namiki (143798), Michihiko Jogi (143790), Shiho Morimoto (143791), Ilkka Julkunen (175083), Koji Onomoto (107253), Kazuhide Onoguchi (107248), Azumi Takemura (143792), Mitsutoshi Yoneyama (107267), Takashi Fujita (89133)   +9 more
core   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Identification of ULK1 as a novel mitophagy-related gene in diabetic nephropathy

Frontiers in Endocrinology, 2023
BackgroundAccumulating evidence indicates that mitophagy is crucial for the development of diabetic nephropathy (DN). However, little is known about the key genes involved.
Yuan-Yuan Yang, Yuan-Yuan Yang, Yuan-Yuan Yang, Yuan-Yuan Yang, Zhong-Xiuzi Gao, Zhong-Xiuzi Gao, Zhong-Xiuzi Gao, Zhong-Xiuzi Gao, Zi-Hui Mao, Zi-Hui Mao, Zi-Hui Mao, Zi-Hui Mao, Dong-Wei Liu, Dong-Wei Liu, Dong-Wei Liu, Dong-Wei Liu, Zhang-Suo Liu, Zhang-Suo Liu, Zhang-Suo Liu, Zhang-Suo Liu, Peng Wu, Peng Wu, Peng Wu, Peng Wu   +23 more
doaj   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations [PDF]

, 2007
Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration.
David C. Chan, Detmer, Scott A., Scott A. Detmer, Chan, David C.   +3 more
core   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3

Advanced Science
Mitofusin 1 (MFN1) plays a crucial role in mitochondrial fusion and oocyte development. However, its function in preimplantation embryonic development and its potential involvement in epigenetic regulation remain poorly understood.
Xiao‐yan Shi, Yu Tian, Yu‐fan Wang, Yi‐ran Zhang, Ying Yin, Qing Tian, Lei Li, Bing‐xin Ma, Ximiao He, Li‐quan Zhou   +9 more
doaj   +1 more source

IPS-1 interacts with MFN1 and MFN2.

, 2013
IPS-1-HeLa cells were infected with NDV for 12 h, and then FLAG-IPS-1 was immunoprecipitated with anti-FLAG antibody. Co-immunoprecipitated MFN1 and MFN2 were detected by anti-MFN1 antibody and anti-MFN2 antibody, respectively.
Shiori Takamatsu (107244), Hideo Namiki (143798), Michihiko Jogi (143790), Shiho Morimoto (143791), Ilkka Julkunen (175083), Koji Onomoto (107253), Kazuhide Onoguchi (107248), Azumi Takemura (143792), Mitsutoshi Yoneyama (107267), Takashi Fujita (89133)   +9 more
core   +1 more source