Results 41 to 50 of about 11,082 (189)
The investigation on the role of mitochondrial fusion protein 1 in the development of myopia
Indian Journal of Ophthalmology, 2016 Purpose: The aim of this study is to preliminarily investigate the expression of mitochondrial fusion protein 1 (MFN1) in a lens-induced animal myopia (LIM) model and to explore the relationship between MFN1 and the visual development.
Yun-Lin Cai +4 more
doaj +1 more source
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. [PDF]
PLoS Pathogens, 2015 Mitochondria are highly dynamic subcellular organelles participating in many signaling pathways such as antiviral innate immunity and cell death cascades. Here we found that mitochondrial fusion was impaired in dengue virus (DENV) infected cells.
Chia-Yi Yu +8 more
doaj +1 more source
تاثیر هشت هفته برنامه آمادهسازی فوتبال و مصرف مکمل بتاولگاریس بر محتوای پروتئینهای OPA1 و MFN1 بازیکنان فوتبال [PDF]
مطالعات کاربردی علوم زیستی در ورزش, 2023 زمینه و هدف: از آنجا که خستگی جسمی ناشی از انجام فعالیت ورزشی طاقت فرسا، بر ساختار و عملکرد سیستم ایمنی تاثیر منفی می گذارد؛ اتخاذ تدابیر تغذیه ای برای تعویق خستگی و ممانعت از افت عملکرد سیستم ایمنی، پیشنهاد می شود.
محمدمهدی منشی +3 more
doaj +1 more source
MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion
EMBO Reports, 2023 Fusion of the outer mitochondrial membrane (OMM) is regulated by mitofusin 1 (MFN1) and 2 (MFN2), yet the differential contribution of each of these proteins is less understood.
Andres Goldman +5 more
doaj +1 more source
Mitofusin 1 is degraded at G2/M phase through ubiquitylation by MARCH5
Cell Division, 2012 Background Mitochondria exhibit a dynamic morphology in cells and their biogenesis and function are integrated with the nuclear cell cycle. In mitotic cells, the filamentous network structure of mitochondria takes on a fragmented form.
Park Yong-Yea, Cho Hyeseong
doaj +1 more source
Cell Reports, 2020 Summary: Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play a major role in inflammation, we studied the contribution of Mfn2 to the ...
Juan Tur +9 more
doaj +1 more source
DENV infection suppresses MFN1-mediated mitochondrial dynamics.
, 2016 (A) Anti-HA and MitoTracker staining of intracellular localization of ectopic-expressed MFN1 and mitochondrial morphology in A549+on/HA-MFN1 cells treated with or without Dox (1 μg/ml, 24 h).
Yi-Ling Lee (155311) +8 more
core +1 more source
Effect of knockdown of Mfn1 or PGC-1α.
, 2021 (A) MCF7 cells transfected with siRNA for Mfn1 were subjected to digitonin fractionation as described in the Materials and Methods and whole cell lysate (WCL), pellets (ppt) or cytosolic extracts (cyto) were blotted using the indicated antibodies.
Fusako Ikeda (361733) +5 more
core +1 more source
Identification of ULK1 as a novel mitophagy-related gene in diabetic nephropathy
Frontiers in Endocrinology, 2023 BackgroundAccumulating evidence indicates that mitophagy is crucial for the development of diabetic nephropathy (DN). However, little is known about the key genes involved.
Yuan-Yuan Yang +23 more
doaj +1 more source
MFN1 is involved in antiviral signaling.
, 2013 A, Schematic representation of the MFN1 domain. B, L929 cells were transfected with a virus-responsive reporter gene (p-125 Luc) and either an empty vector (Empty), an expression vector for MFN1, or an expression vector for MFN2 as indicated.
Shiori Takamatsu (107244) +9 more
core +1 more source