Results 61 to 70 of about 11,908 (171)

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries

BMC Biology, 2021
Background Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins.
Rong Yu, Tong Liu, Shao-Bo Jin, Maria Ankarcrona, Urban Lendahl, Monica Nistér, Jian Zhao   +6 more
doaj   +1 more source

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction [PDF]

, 2016
Mitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as the sarcoplasmic reticulum (SR).
Burke, N, Hall, A.R, Hausenloy, DJ, Vicencio, J M, Dongworth, RK, Hausenloy, D.J, Kalkhoran, S.B, Vicencio, JM, Yellon, D M, Dongworth, R K, Dorn, G.W, Hausenloy, D J, Kalkhoran, SB, Yellon, D.M, Dorn Ii, GW, Hall, AR, Yellon, DM, Dyson, A, Dorn II, G W, Vicencio, J.M, Hall, A R, Dongworth, R.K   +21 more
core   +1 more source

The role of Mfn1 in the downregulation of mitochondrial biogenesis in the mtDNA-priming antiviral response.

, 2021
(A-C) Vero-hSLAM cells were transfected with siRNA for the NC or Mfn1. (A) Cell lysates analyzed to western blotting. (B) Cells infected with rMV-EGFP. At 16 hpi, mitochondria were stained with MitoTracker. Scale bar = 10 μm.
Fusako Ikeda (361733), Tomoko Fujiyuki (253396), Hiroki Sato (105731), Miho Hoshi (11564719), Misako Yoneda (361730), Chieko Kai (361737)   +5 more
core   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Role of Mitofusin 1 in mediating reactive oxygen species in alveolar macrophages during Streptococcus pneumoniae

Redox Biology
Alveolar macrophages (AM) are key effectors of the immune response and are essential for host responses to S. pneumoniae. Mitochondria are highly dynamic organelles whose function aids in regulating the cell cycle, innate immunity, autophagy, redox ...
David Thomas, Jianjun Yang, Soo Jung Cho, Heather Stout-Delgado   +3 more
doaj   +1 more source

Identificació de les xarxes d’interacció de Mitofusina-1 i Mitofusina-2 [PDF]

, 2021
[eng] Mitofusins (MFN1/2) have been demonstrated to play a role in several mitochondrial functions such as mitochondrial dynamics and bioenergetics, interorganelle communication, immune response, autophagy, cell cycle progression, cellular senescence and
Gordaliza Alaguero, Isabel
core   +2 more sources

C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia

Scientific Reports
Cytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases.
Alejandra Gonzalez Martinez, Franz Josef Gassner, Dominik Baumgartner, Philine Hoven, Ekaterina Akimova, Markus Steiner, Stephanie Schlichtner, Stefanie Rauscher, Ferran Nadeu, Elias Campo, Richard Greil, Alexander Egle, Lisa Pleyer, Nadja Zaborsky, Roland Geisberger   +14 more
doaj   +1 more source

Mfn1, Mfn2, OPA1, and Fis1 protein expression in neurons following OGD.

, 2013
Representative western blots are shown for Mfn1 (A), Mfn2 (C), OPA1 (E), and Fis1 (G) with their corresponding β-actin blots. Panels B, D, F, and H show relative intensity bar graphs for the same proteins as means ± s.e.m. of n≥3 independent experiments.
Somhrita Dutta (409386), Edina A. Wappler (303781), David W. Busija (302558), Adam Institoris (302552), Prasad V. G. Katakam (409387)   +4 more
core   +1 more source