Results 61 to 70 of about 11,082 (189)

DENV cleaves human MFN1 and MFN2.

, 2016
(A) Alignment of amino acid sequences surrounding the MFN1 and MFN2 cleavage sites of DENV protease. The wild-type (WT) and mutated MFNs used in this study and the relative position of each domain are illustrated.
Yi-Ling Lee (155311), Wei-Jheng Huang (840697), Jian-Jong Liang (155301), Michael M. C. Lai (139950), Jin-Kun Li (840695), Bi-Lan Chang (713473), Chan-I Su (840696), Chia-Yi Yu (141345), Yi-Ling Lin (63628)   +8 more
core   +1 more source

Paper de les proteïnes de fusió mitocondrial Opa1 i Mfn1 durant la diferenciació miogènica [PDF]

, 2014
Les mitocòndries generen la major part de l’energia necessària per a la funció cel·lular mitjançant la respiració i la fosforilació oxidativa. Quan els mioblasts diferencien a miotubs, la biogènesi mitocondrial i l’activitat enzimàtica mitocondrial ...
Noguera Jordà, Eduard
core   +2 more sources

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Guanxinning Injection Combined With Ischemic Postconditioning Attenuate Myocardial Ischemic Reperfusion Injury in Chronic Renal Failure Rats by Modulating Mitochondrial Dynamics

Frontiers in Cardiovascular Medicine, 2022
PurposeSalvia miltiorrhiza Bge. (Danshen, DS) and Ligusticum chuanxiong Hort. (Chuanxiong, CX) have been widely used in traditional Chinese medicine to prevent and treat myocardial ischemia and renal insufficiency, and their extracts (Guanxinning ...
Anzhu Wang, Anzhu Wang, Dawu Zhang, Dawu Zhang, Jiangang Liu, Jiangang Liu, Huijing Yan, Huijing Yan, Pei Zhang, Pei Zhang, Hui Yuan, Hui Yuan, Xiaochang Ma, Xiaochang Ma   +13 more
doaj   +1 more source

MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries

BMC Biology, 2021
Background Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins.
Rong Yu, Tong Liu, Shao-Bo Jin, Maria Ankarcrona, Urban Lendahl, Monica Nistér, Jian Zhao   +6 more
doaj   +1 more source

The role of Mitofusin-1 and Mitofusin-2 in periodontal disease: a comprehensive review

Frontiers in Oral Health
Periodontal disease is a widespread chronic inflammatory state influencing the supporting anatomy of the teeth, distinguished by oxidative stress, progressive bone loss, and tissue damage.
Sudhir R. Varma, Sudhir R. Varma, Omar H. A. A. Ani, Jayaraj K. Narayanan, Jayaraj K. Narayanan, Asok Mathew, Asok Mathew   +6 more
doaj   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

The role of Mfn1 in the downregulation of mitochondrial biogenesis in the mtDNA-priming antiviral response.

, 2021
(A-C) Vero-hSLAM cells were transfected with siRNA for the NC or Mfn1. (A) Cell lysates analyzed to western blotting. (B) Cells infected with rMV-EGFP. At 16 hpi, mitochondria were stained with MitoTracker. Scale bar = 10 μm.
Fusako Ikeda (361733), Tomoko Fujiyuki (253396), Hiroki Sato (105731), Miho Hoshi (11564719), Misako Yoneda (361730), Chieko Kai (361737)   +5 more
core   +1 more source

miR-125b Disrupts Mitochondrial Dynamics via Targeting Mitofusin 1 in Cisplatin-Induced Acute Kidney Injury

Kidney Diseases, 2021
Background: Mitochondria are dynamic organelles whose structure are maintained by continuous fusion and fission. During acute kidney injury (AKI) progression, mitochondrial fission in renal tubular cells was elevated, characterized by mitochondrial ...
Yue Zhao, Yue Lang, Mingchao Zhang, Shaoshan Liang, Xiaodong Zhu, Zhihong Liu   +5 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source