Results 81 to 90 of about 11,908 (171)

Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1 [PDF]

, 2010
In virus-infected cells, RIG-I-like receptor (RLR) recognizes cytoplasmic viral RNA and triggers innate immune responses including production of type I and III interferon (IFN) and the subsequent expression of IFN-inducible genes.
Hideo Namiki, Takamatsu S, Morimoto S, Yoneyama, Mitsutoshi, Julkunen I, Takamatsu, Shiori, Kazuhide Onoguchi, Onomoto, Koji, Michihiko Jogi, Ilkka Julkunen, Onomoto K, Jogi, Michihiko, Shiho Morimoto, Fujita T, Jogi M, Namiki H, Namiki, Hideo, Mitsutoshi Yoneyama, Onoguchi, Kazuhide, Shiori Takamatsu, Onoguchi K, Azumi Takemura, Julkunen, Ilkka, Koji Onomoto, Fujita, Takashi, Yoneyama M, Morimoto, Shiho, Takashi Fujita, Takemura, Azumi, Takemura A   +29 more
core   +2 more sources

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin

, 2016
Mitochondrial function can be influenced by mitochondrial shape and connectivity with other cellular organelles through fusion and fission processes.
Boutant, Marie, Descombes, Patrick, Maclachlan, Catherine, Zorzano, Antonio, Ratajczak, Joanna, Hernandez-Alvarez, Maria Isabel, Canto, Caries, Kulkarni, Sameer S., Gao, Arwen W., Joffraud, Magali, Raymond, Frederic, Houtkooper, Riekelt H., Metairon, Sylviane   +12 more
core   +2 more sources

Corrigendum: Tang Luo Ning, a Traditional Chinese Compound Prescription, Ameliorates Schwannopathy of Diabetic Peripheral Neuropathy Rats by Regulating Mitochondrial Dynamics In Vivo and In Vitro

Frontiers in Pharmacology, 2021
Jiayue Zhu, Jiayue Zhu, Xinwei Yang, Xinwei Yang, Xiao Li, Xiao Li, Shuo Han, Shuo Han, Yanbo Zhu, Yanbo Zhu, Liping Xu, Liping Xu   +11 more
doaj   +1 more source

Baicalin inhibits infectious bronchitis virus replication via MAVS-dependent interferon-β upregulation and mitochondrial function preservation

Scientific Reports
The inhibitory effect of baicalin on infectious bronchitis virus (IBV) replication is closely related to expression of the mitochondrial antiviral signaling protein (MAVS) in chicken embryonic kidney (CEK) cells.
Jiongjie He, Huilin Guo, Ling Wang, Shengyi Wang   +3 more
doaj   +1 more source

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria [PDF]

, 2017
SCL25A46 is a mitochondrial carrier protein that surprisingly localizes to the outer membrane and is distantly related to Ugo1. Here we show that a subset of SLC25A46 interacts with mitochondrial dynamics components and the MICOS complex.
Steffen, Janos, Koehler, Carla M, Jen, Joanna C, Vashisht, Ajay A, Wan, Jijun, Wohlschlegel, James A, Claypool, Steven M   +6 more
core   +1 more source

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

Experimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova, Evgenii Lysenko, Fabio Sarto, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +6 more
wiley   +1 more source

Mfn1 was required for the cytoprotective effect of IB5 and PKM2.

, 2019
The effect of IB5 and PKM2 on mitochondrial morphology. PKM2-deficient MEFs reconstituted with WT PKM2 or PKM2 (K422R) cDNA were infected or not with IB5 lentivirus. A.
Matthew G. Vander Heiden (1593610), Hongkai Zhang (4635649), Tong Liu (107783), Richard A. Lerner (363483), Donald D. Newmeyer (132850), Tomomi Kuwana (132845)   +5 more
core   +1 more source

Contribution of 3q26-29 gene cluster to glioma invasion [PDF]

, 2015
Diffuse gliomas are the most common and lethal brain tumors. Cell invasion into the surrounding brain tissue is a hallmark feature of glioma. Understanding the mechanism of glioma invasion could lead to the discovery of novel therapeutic strategies to ...
Ramadoss, Archana
core   +1 more source

Mitochondrial capacities and quality control following short‐ and long‐term weight restoration after simulated anorexia nervosa

Experimental Physiology, EarlyView.
Abstract Anorexia nervosa (AN) is a psychiatric disorder characterized by prolonged caloric restriction and skeletal muscle atrophy. Mitochondrial health is a key mediator of muscle function, yet the role of mitochondria during AN and following weight regain has not been investigated. The objective of this study was to evaluate mitochondrial capacities
Megan E. Rosa‐Caldwell, Toby L. Chambers, Lauren Breithaupt, Ruqaiza Muhyudin, Patience Salvalina Okoto, Sadie R. Thompson, Emily E. Rothacker, Claire Greenhill, Katie A. Wood, Kevin A. Murach, Sarah H. White‐Springer, Ursula B. Kaiser, Seward B. Rutkove   +12 more
wiley   +1 more source