Results 101 to 110 of about 11,082 (189)

Elucidation of interactors of the pro-fusion proteins MFN1 and MFN2 sheds light on novel pathways regulating mitochondrial morphology in apoptosis

, 2013
Large-scale proteomics analysis provide information on the proteomic signatures including interacting partners and post-translational modification. In the first part of the thesis, we identified a novel keratin-binding protein, Trichoplein (TpMs) that ...
Pyakurel, Aswin
core   +1 more source

The Effect of Eight Weeks of Aerobic Training Combined With Resveratrol on MFn1 and MFn2 Expression in Cardiac Myocytes in a Non-alcoholic Fatty Liver Animal Model

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2020
Objective: Nonalcoholic fatty liver disease is the most common chronic liver disorder. The present study aimed to examine the effect of aerobic training along with Resveratrol on the cardiac expression of Mfn1 and Mfn2 in nonalcoholic fatty liver disease
Hasan Delroz, Ahmad Abdi, Alireza Barari, Parvin Farzanegi   +3 more
doaj  

The Interaction Effect of Aerobic Exercise and Atorvastatin Consumption on the expression level of MFN1/2 and DRP1 in Hepatocytes of the Rat Liver with Type 2 Diabetes

Journal of Ardabil University of Medical Sciences, 2021
Background & objectives: Dynamic disorders of mitochondria cause the pathogenesis of many diseases, such as type 2 diabetes. Therefore, the aim of this study was to investigate the interactive effect of aerobic exercises and atorvastatin consumption on ...
Maryam Zolfali Pourfar, Farhad Rahmani Nia, Parvin Farzanegi   +2 more
doaj  

Identificació de les xarxes d’interacció de Mitofusina-1 i Mitofusina-2 [PDF]

, 2021
[eng] Mitofusins (MFN1/2) have been demonstrated to play a role in several mitochondrial functions such as mitochondrial dynamics and bioenergetics, interorganelle communication, immune response, autophagy, cell cycle progression, cellular senescence and
Gordaliza Alaguero, Isabel
core  

Identification of the interaction networks of Mitofusin-1 and Mitofusin-2 = Identificació de les xarxes d’interacció de Mitofusina-1 i Mitofusina-2 [PDF]

, 2021
Programa de Doctorat en Biomedicina / Tesi realitzada a l'Institut de Recerca Biomèdica de Barcelona (IRBB)Mitofusins (MFN1/2) have been demonstrated to play a role in several mitochondrial functions such as mitochondrial dynamics and bioenergetics ...
Gordaliza Alaguero, Isabel
core  

Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease

Frontiers in Cell and Developmental Biology
Mitochondrial dynamics, involving fission and fusion, are vital for maintaining mitochondrial quality, shape, and function in heart cells. This review explores how key regulators—Dynamin-related protein 1 (Drp1), mitofusins 1 and 2 (Mfn1/2), and Optic ...
Tengxu Zhang, Ziwei Li, Ying Xu, Chaoqun Xu, Hao Wang, Tao Rui   +5 more
doaj   +1 more source

Mitofusins in murine oocytes: their roles in fertility and mitochondrial inheritance

, 2020
Durante a oogênese o oócito sofre intensas mudanças quanto a morfologia mitocondrial e número de organelas. Uma vez que a fusão e fissão mitocondrial atuam diretamente na dinâmica mitocondrial, tais processos devem ser determinantes para o ...
Machado, Thiago Simões
core   +1 more source

Time-resolved tmFRET reveals GTP-coupled conformational changes in Mfn1

Journal of Cell Biology
Outer mitochondrial membrane fusion is mediated by the mitofusin paralogs Mfn1 and Mfn2. Nucleotide-driven self-assembly and conformational changes are required for regulated membrane fusion activity, but the allosteric mechanisms remain enigmatic due to incomplete structural information.
Sophie M. Hurwitz, William N. Zagotta, Sharona E. Gordon, Suzanne Hoppins   +3 more
openaire   +1 more source

Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy

Scientific Reports
Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and mitochondrial
Doménica Tarallo, Jennyfer Martínez, Alejandro Leyva, Amy Mónaco, Carolina Perroni, Marcos Tassano, Juan Pablo Gambini, Mónica Cappetta, Rosario Durán, María Moreno, Celia Quijano   +10 more
doaj   +1 more source

MFN1 is required for follicle development, oocyte maturation, and female fertility [PDF]

Fertility and Sterility, 2018
M. Zhang, M.B. Bener, Z. Jiang, T. Wang, E. Esencan, R. Scott, E. Seli   +6 more
openaire   +1 more source