Results 101 to 110 of about 11,908 (171)

Elucidation of interactors of the pro-fusion proteins MFN1 and MFN2 sheds light on novel pathways regulating mitochondrial morphology in apoptosis

, 2013
Large-scale proteomics analysis provide information on the proteomic signatures including interacting partners and post-translational modification. In the first part of the thesis, we identified a novel keratin-binding protein, Trichoplein (TpMs) that ...
Pyakurel, Aswin
core   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

Effects of Intermittent Leg Blood-Flow Occlusion and Aerobic Exercise on Cardiac Mitochondrial Dynamics in a Rat Model of Myocardial Infarction [PDF]

مجله دانشگاه علوم پزشکی گرگان
Background and Objective: Cardiac mitochondrial dysfunction is well recognized in ischemic heart disease, and mitochondria appear to play an important role in the exercise-induced cardioprotective effects observed after myocardial infarction.
Hoda Yazdani, Amin Farzaneh Hesari, Hajar Abaszadeh, Abdolreza Jafari Chashmi   +3 more
doaj  

Repeated Moderate and Severe Heat Exposure Has Divergent Effects on Skeletal Muscle Mitochondrial, Proteostatic and Neuromuscular Outcomes in Mice

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Repeated heat exposure may promote adaptive remodeling or cumulative tissue burden depending on thermal dose, but its graded molecular and functional consequences during recovery remain unclear. We examined whether repeated moderate (39°C) and severe (41°C) whole‐body hyperthermia produce distinct skeletal muscle trajectories involving ...
Cansu Yakin, Cihan Suleyman Erdogan, Fatma Ozge Tuncel, Yunus Kosif, Bayram Yilmaz   +4 more
wiley   +1 more source

Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease

Frontiers in Cell and Developmental Biology
Mitochondrial dynamics, involving fission and fusion, are vital for maintaining mitochondrial quality, shape, and function in heart cells. This review explores how key regulators—Dynamin-related protein 1 (Drp1), mitofusins 1 and 2 (Mfn1/2), and Optic ...
Tengxu Zhang, Ziwei Li, Ying Xu, Chaoqun Xu, Hao Wang, Tao Rui   +5 more
doaj   +1 more source

Study on the inhibition of Mfn1 by plant-derived miR5338 mediating the treatment of BPH with rape bee pollen

, 2018
Background Recent studies have found that plant derived microRNA can cross-kingdom regulate the expression of genes in humans and other mammals, thereby resisting diseases.
Xuan Chen, Ren-zhao Wu, Yong-qiang Zhu, Feng Yang, Ze-ming Ren, Ye-ling Tong, Guan-hai Dai   +6 more
core   +1 more source

Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy

Scientific Reports
Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and mitochondrial
Doménica Tarallo, Jennyfer Martínez, Alejandro Leyva, Amy Mónaco, Carolina Perroni, Marcos Tassano, Juan Pablo Gambini, Mónica Cappetta, Rosario Durán, María Moreno, Celia Quijano   +10 more
doaj   +1 more source

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

Nature Communications
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a ...
Vanessa López-Polo, Mate Maus, Emmanouil Zacharioudakis, Miguel Lafarga, Camille Stephan-Otto Attolini, Francisco D. M. Marques, Marta Kovatcheva, Evripidis Gavathiotis, Manuel Serrano   +8 more
doaj   +1 more source

Genetic disruption of mitochondrial dynamics and stasis leads to liver injury and tumorigenesis

The Journal of Clinical Investigation
Mitochondrial fission is mediated by dynamin-related protein 1 (gene name DNM1L) and fusion by mitofusins (MFN1 and MFN2) and optic atrophy 1. The role of mitochondrial dynamics in liver disease and cancer remains poorly understood.
Xiaowen Ma, Xiaoli Wei, Mengwei Niu, Chen Zhang, Zheyun Peng, Wanqing Liu, Junrong Yan, Xiaoyang Su, Lichun Ma, Shaolei Lu, Wei Cui, Hiromi Sesaki, Wei-Xing Zong, Hong-Min Ni, Wen-Xing Ding   +14 more
doaj   +1 more source

Silencing MFN1 or MFN2 reveals their distinct roles in DENV infection.

, 2016
(A and B) RT-qPCR (A) and western blot (B) validation of A549 cells stably expressing shRNA targeting LacZ, MFN1 or MFN2. Data in panels A and C-F are mean ± SD (n = 3 per group) and were compared by two-tailed Student’s t test. Quantification in panel B
Yi-Ling Lee (155311), Wei-Jheng Huang (840697), Jian-Jong Liang (155301), Michael M. C. Lai (139950), Jin-Kun Li (840695), Bi-Lan Chang (713473), Chan-I Su (840696), Chia-Yi Yu (141345), Yi-Ling Lin (63628)   +8 more
core   +1 more source