Results 91 to 100 of about 11,908 (171)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

The Regulation of Mfn1-Mediated Mitochondrial Outer Membrane Fusion [PDF]

Thesis (Ph.D.)--University of Washington, 2025Mitochondria are often depicted in textbooks as static organelles whose principal purpose is to power cells; however, they are constantly moving and morphing shape in response to cellular requirements which ...
Martinez Bocanegra, Jennifer
core  

MFN1 plays a critical role in RIG-I–induced signaling.

, 2013
A and B, Wild-type (WT) MEFs and Mfn1 or Mfn2-knockout MEFs were infected with NDV for 9 h. The levels of endogenous Ifna4 (A) and Ifnb1 (B) mRNA were quantified by qRT-PCR.
Shiori Takamatsu (107244), Hideo Namiki (143798), Michihiko Jogi (143790), Shiho Morimoto (143791), Ilkka Julkunen (175083), Koji Onomoto (107253), Kazuhide Onoguchi (107248), Azumi Takemura (143792), Mitsutoshi Yoneyama (107267), Takashi Fujita (89133)   +9 more
core   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Salivary mitofusin levels in periodontal disease: a cross-sectional case-control study

BMC Oral Health
Background Mitofusin (Mfn) is a mitochondrial fusion protein. It has two isoforms (Mfn1 and 2) and is critical in intracellular energy production, calcium transfer, and phospholipid metabolism.
Ömer F. Okumuş, Nezahat Kurt, Alpdoğan Kantarcı   +2 more
doaj   +1 more source

Baicalin Alleviates Lactational Heat‐Stress‐Induced Hepatic Mitochondrial Dysfunction via Sirt3‐Dependent Deacetylation of NDUFS1

Food Frontiers, Volume 7, Issue 6, November 2026.
This study reveals that lactational HS suppresses Sirt3 activity, leading to hyperacetylation of the complex I subunit NDUFS1, and excessive mitochondrial ROS production, whereas BAI, a nature food‐derived bioactive compound, alleviates lactational HS‐induced hepatic mitochondrial injury by activating the Sirt3–NDUFS1 axis to deacetylate mitochondrial ...
Jingzheng Li, Honglin Jiang, Jianwen He, Wen Yao   +3 more
wiley   +1 more source

The Effect of Eight Weeks of Aerobic Training Combined With Resveratrol on MFn1 and MFn2 Expression in Cardiac Myocytes in a Non-alcoholic Fatty Liver Animal Model

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2020
Objective: Nonalcoholic fatty liver disease is the most common chronic liver disorder. The present study aimed to examine the effect of aerobic training along with Resveratrol on the cardiac expression of Mfn1 and Mfn2 in nonalcoholic fatty liver disease
Hasan Delroz, Ahmad Abdi, Alireza Barari, Parvin Farzanegi   +3 more
doaj  

The Interaction Effect of Aerobic Exercise and Atorvastatin Consumption on the expression level of MFN1/2 and DRP1 in Hepatocytes of the Rat Liver with Type 2 Diabetes

Journal of Ardabil University of Medical Sciences, 2021
Background & objectives: Dynamic disorders of mitochondria cause the pathogenesis of many diseases, such as type 2 diabetes. Therefore, the aim of this study was to investigate the interactive effect of aerobic exercises and atorvastatin consumption on ...
Maryam Zolfali Pourfar, Farhad Rahmani Nia, Parvin Farzanegi   +2 more
doaj  

Mitochondrial Metabolic Reprogramming in Glioma: Mechanisms of Tumorigenesis and Implications for Clinical Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In gliomas, mitochondria integrate glucose, lipid, protein, and nucleotide metabolism to support proliferation, invasion, treatment resistance, and adaptation, with D‐2‐hydroxyglutarate‐driven remodeling in IDH‐mutant tumors and diverse metabolic states in IDH wild‐type glioblastomas.
Liangqi Jiang, Mingrui Li, Zhen Li, Qing Liu, Yang Li   +4 more
wiley   +1 more source