Results 71 to 80 of about 11,908 (171)

تاثیر همزمان مکمل یاری کرم آرد با تمرین هوازی بر بیان برخی ژن‌های میتوکندریایی در عضله نعلی موش‌های صحرایی مبتلا به کبد چرب غیرالکلی [PDF]

مطالعات کاربردی علوم زیستی در ورزش
زمینه و هدف: در این تحقیق تاثیر همزمان مکمل پروتئینی کرم آرد  با تمرین هوازی بر بیان ژن‌های دخیل در بیوژنز میتوکندریایی شامل گیرنده فعال شده توسط پراکسی زوم گاما هم‌فعال کننده یک-آلفا (PGC1α)، پروتئین جفت نشده-یک (UCP1)،  پروتئین‌های میتوفیوژن (Mfn1) و ...
سمیه پایکاری, علیرضا رحیمی, فریبا آقایی, فواد فیض الهی   +3 more
doaj   +1 more source

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated beta-Cell Connectivity and Insulin Secretion

, 2022
Only Vanderbilt University affiliated authors are listed on VUIR. For a full list of authors, access the version of record at https://diabetesjournals.org/diabetes/article/71/7/1472/145040/Mitofusins-Mfn1-and-Mfn2-Are-Required-to-PreserveMitochondrial ...
Xu, Yanwen, Gu, Guoqiang
core   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Effects of MFN1 or MFN2 overexpression on DENV infection.

, 2016
(A) Western blot analysis of A549+on/HA-MFN1 cells induced with Dox (1 μg/ml) or not for 18 h, then infected with DENV serotype 2 for 24 or 48 h by the indicated moi. The relative ratios of band intensity were quantified by ImageJ. p.i.
Yi-Ling Lee (155311), Wei-Jheng Huang (840697), Jian-Jong Liang (155301), Michael M. C. Lai (139950), Jin-Kun Li (840695), Bi-Lan Chang (713473), Chan-I Su (840696), Chia-Yi Yu (141345), Yi-Ling Lin (63628)   +8 more
core   +1 more source

Ginsenoside Rh1 Attenuates Alzheimer's Disease‐Like Deficits by Modulating Oxidative Stress and Mitochondrial Dysfunction via SIRT1‐Related Signaling

Phytotherapy Research, EarlyView.
Rh1 attenuates oxidative stress and mitochondrial dysfunction through SIRT1‐related signaling. ABSTRACT Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully ...
Shi‐Lu Li, Tao Lin, Wan‐chen Zou, Ya‐jun Wang, Jing‐tian Zhang, Zi Wang, Hong‐yuan Li, Long Chen, Li‐chun Zhao, Shen Ren, Wei Li   +10 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Correlation between polymorphisms in the MFN1 gene and myopia in Chinese population [PDF]

, 2015
AIM: To explore whether genetic variations in the MFN1 gene are associated with low to moderate myopia in Chinese population. METHODS: The case-control association analysis was used.
Jia-Hong Lei, Yun-Chun Zou, Shuang Xu, Ying Wang   +3 more
core   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

Mapping the Bioenergetic Landscape of Oral Cancer Stem Cells: A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Objectives Oral squamous cell carcinoma (OSSC) remains highly lethal, with resistance largely driven by cancer stem cells (CSCs). Mitochondrial reprogramming supports CSC redox control, self‐renewal, and survival. This systematic review aimed to synthesize mitochondrial mechanisms sustaining CSCs in OSCC and evaluate their therapeutic ...
Rodrigo Elísio de Sá, Rebeca Barbosa da Rocha, Benedito dos Santos Alves, Maria Eduarda de Araujo de Carvalho, Jayane da Silva Sousa, José Delano Barreto Marinho‐Filho, Ana Jérsia Araújo   +6 more
wiley   +1 more source