Results 71 to 80 of about 11,082 (189)

Role of Mitofusin 1 in mediating reactive oxygen species in alveolar macrophages during Streptococcus pneumoniae

Redox Biology
Alveolar macrophages (AM) are key effectors of the immune response and are essential for host responses to S. pneumoniae. Mitochondria are highly dynamic organelles whose function aids in regulating the cell cycle, innate immunity, autophagy, redox ...
David Thomas, Jianjun Yang, Soo Jung Cho, Heather Stout-Delgado   +3 more
doaj   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Mfn1, Mfn2, OPA1, and Fis1 protein expression in neurons following OGD.

, 2013
Representative western blots are shown for Mfn1 (A), Mfn2 (C), OPA1 (E), and Fis1 (G) with their corresponding β-actin blots. Panels B, D, F, and H show relative intensity bar graphs for the same proteins as means ± s.e.m. of n≥3 independent experiments.
Somhrita Dutta (409386), Edina A. Wappler (303781), David W. Busija (302558), Adam Institoris (302552), Prasad V. G. Katakam (409387)   +4 more
core   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

تاثیر همزمان مکمل یاری کرم آرد با تمرین هوازی بر بیان برخی ژن‌های میتوکندریایی در عضله نعلی موش‌های صحرایی مبتلا به کبد چرب غیرالکلی [PDF]

مطالعات کاربردی علوم زیستی در ورزش
زمینه و هدف: در این تحقیق تاثیر همزمان مکمل پروتئینی کرم آرد  با تمرین هوازی بر بیان ژن‌های دخیل در بیوژنز میتوکندریایی شامل گیرنده فعال شده توسط پراکسی زوم گاما هم‌فعال کننده یک-آلفا (PGC1α)، پروتئین جفت نشده-یک (UCP1)،  پروتئین‌های میتوفیوژن (Mfn1) و ...
سمیه پایکاری, علیرضا رحیمی, فریبا آقایی, فواد فیض الهی   +3 more
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated beta-Cell Connectivity and Insulin Secretion

, 2022
Only Vanderbilt University affiliated authors are listed on VUIR. For a full list of authors, access the version of record at https://diabetesjournals.org/diabetes/article/71/7/1472/145040/Mitofusins-Mfn1-and-Mfn2-Are-Required-to-PreserveMitochondrial ...
Xu, Yanwen, Gu, Guoqiang
core   +1 more source

CB1 receptor antagonist rimonabant protects against chronic intermittent hypoxia-induced renal injury in rats

BMC Nephrology, 2021
Background Obstructive sleep apnoea (OSA) induced chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH). Our study investigate the mechanism underlying CIH-induced renal damage and whether the cannabinoid receptor 1 (CB1R ...
Li Zhao, Tao Liu, Zhan-jun Dou, Mei-ting Wang, Zi-xuan Hu, Bei Wang   +5 more
doaj   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia

Scientific Reports
Cytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases.
Alejandra Gonzalez Martinez, Franz Josef Gassner, Dominik Baumgartner, Philine Hoven, Ekaterina Akimova, Markus Steiner, Stephanie Schlichtner, Stefanie Rauscher, Ferran Nadeu, Elias Campo, Richard Greil, Alexander Egle, Lisa Pleyer, Nadja Zaborsky, Roland Geisberger   +14 more
doaj   +1 more source