Nature CommunicationsThe escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a ...
Vanessa López-Polo +8 more
doaj +1 more source
Silencing MFN1 or MFN2 reveals their distinct roles in DENV infection.
, 2016 (A and B) RT-qPCR (A) and western blot (B) validation of A549 cells stably expressing shRNA targeting LacZ, MFN1 or MFN2. Data in panels A and C-F are mean ± SD (n = 3 per group) and were compared by two-tailed Student’s t test. Quantification in panel B
Yi-Ling Lee (155311) +8 more
core +1 more source
, 2012 Mitochondrial dynamics and distribution is critical for their role in bioenergetics and cell survival. We investigated the consequence of altered fission/fusion on mitochondrial function and motility in INS-1E rat clonal β-cells.
Wiederkehr, Andreas +2 more
core +1 more source
The Regulation of Mfn1-Mediated Mitochondrial Outer Membrane Fusion
Thesis (Ph.D.)--University of Washington, 2025Mitochondria are often depicted in textbooks as static organelles whose principal purpose is to power cells; however, they are constantly moving and morphing shape in response to cellular requirements which ...
Martinez Bocanegra, Jennifer
core
Correction: Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction [PDF]
Cell Death & Disease, 2021 A. R. Hall +8 more
openaire +2 more sources
Fertility effect of the knockout of Mitofusin 1 on murine oocytes
, 2018 Fertility is directly related to oocyte developmental competence. In this context, oocyte mitochondria play a crucial role and have become an important target in assisted reproduction therapies.
Carvalho, Karen Freire
core
Mitochondrial Dynamics in Cancer Progression and Therapy Resistance: Emerging Roles in Metabolic Reprogramming, Biomarker Discovery, and Precision Medicine. [PDF]
CellsPenugurti V, Kant R, Hsu CC.
europepmc +1 more source
MTFR2 regulated the proliferation, apoptosis, migration, and invasion of endometrial cancer cells through the Drp1/MFN1 signaling pathway mediated mitochondrial fission. [PDF]
Transl Cancer ResBai X, Wei M, Wang Q, Yang Y.
europepmc +1 more source
Role of recombinant S100A13 expression in regulating mitochondrial fission and fusion in lung epithelial cells. [PDF]
BBA AdvAlqattan S +5 more
europepmc +1 more source
Megamitochondria in alcohol-associated liver disease and cancer: a friend or foe? [PDF]
eGastroenterologyNiu M, Wei X, Ma X, Ding WX.
europepmc +1 more source