Results 21 to 30 of about 11,082 (189)
The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes
Communications Biology, 2022 The MFN1 and MFN2 mitofusin proteins localize to the outer mitochondrial membrane, where they may help functionally tether mitochondria to peroxisomes.
Yinbo Huo +4 more
doaj +3 more sources
Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
Cell Death & Disease, 2016 AbstractMitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as the sarcoplasmic reticulum (SR). Inhibiting mitochondrial fission can protect the heart against acute ischemia/reperfusion (I/R) injury ...
Hall, A.R +8 more
openaire +6 more sources
Correlation between polymorphisms in the MFN1 gene and myopia in Chinese population.
International journal of ophthalmology, 2015 To explore whether genetic variations in the MFN1 gene are associated with low to moderate myopia in Chinese population.The case-control association analysis was used. The study included 100 independent myopia patients (-0.75 D ≤ spherical refraction ≤-8.00 D) and 100 sex-matched healthy controls (with binocular spherical equivalent ranges between -0 ...
Yun-Chun Zou +3 more
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Study on the inhibition of Mfn1 by plant-derived miR5338 mediating the treatment of BPH with rape bee pollen [PDF]
BMC Complementary and Alternative Medicine, 2018 Recent studies have found that plant derived microRNA can cross-kingdom regulate the expression of genes in humans and other mammals, thereby resisting diseases. Can exogenous miRNAs cross the blood-prostate barrier and entry prostate then participate in prostate disease treatment?Using HiSeq sequencing and RT-qPCR technology, we detected plant miRNAs ...
Xuan Chen +6 more
openaire +4 more sources
CellsMitochondria maintain cellular homeostasis through the dynamic balance of fusion and fission, which relies on nuclear-encoded mitochondrial fusion proteins, mitofusins 1 and 2 (Mfn1, Mfn2).
Han Xu +9 more
doaj +3 more sources
Salivary mitofusin levels in periodontal disease: a cross-sectional case-control study [PDF]
BMC Oral HealthBackground Mitofusin (Mfn) is a mitochondrial fusion protein. It has two isoforms (Mfn1 and 2) and is critical in intracellular energy production, calcium transfer, and phospholipid metabolism.
Ömer F. Okumuş +2 more
doaj +2 more sources
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
Nature Communications, 2019 We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1 ...
Julio C. B. Ferreira +11 more
doaj +2 more sources
Role of GTPase-Dependent Mitochondrial Dynamins in Heart Diseases
Frontiers in Cardiovascular Medicine, 2021 Heart function maintenance requires a large amount of energy, which is supplied by the mitochondria. In addition to providing energy to cardiomyocytes, mitochondria also play an important role in maintaining cell function and homeostasis.
Jiangen Liu +3 more
doaj +1 more source
Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity
Frontiers in Bioscience-Landmark, 2022 Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China.
Jinling Wang +6 more
doaj +1 more source
Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy
Scientific Reports, 2021 Prognosis of severe heart failure remains poor. Urgent new therapies are required. Some heart failure patients do not respond to established multidisciplinary treatment and are classified as “non-responders”.
Yung Ting Hsiao +14 more
doaj +1 more source