Results 21 to 30 of about 11,908 (171)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

The effects of endurance training and estrogen-related receptor α disruption on mitofusin 1 and 2, GLUT2, PPARβ/δ and SCD1 expression in the liver of diabetic rats [PDF]

The Ukrainian Biochemical Journal, 2020
Diabetes is a progressive and metabolic disease with a high prevalence throughout the world. Physical activity is considered as an intervention to improve diabetes. Intervention such as estrogen-related receptor α (ERRα) inhibition is considered as a new
B. Shahouzehi, Y. Masoumi-Ardakani, H. Fallah, S. Aminizadeh   +3 more
doaj   +1 more source

Gemini-Based Lipoplexes Complement the Mitochondrial Phenotype in MFN1-Knockout Mouse Embryonic Fibroblasts

, 2019
Mitochondria form a dynamic network of constantly dividing and fusing organelles. The balance between these antagonistic processes is crucial for normal cellular function and requires the action of specialized proteins.
López-Montero, Iván, López Montero, Iván, Muñoz Úbeda, Mónica, Bhattacharya, Santanu, Tolosa Díaz, Andrés, Muñoz-Úbeda, Mónica, Junquera, Elena, Aicart, Emilio, Aicart Sospedra, Emilio, Natale, Paolo, Tolosa-Díaz, Andrés, Junquera González, María Elena   +11 more
core   +2 more sources

Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking

Molecular & Cellular Oncology, 2018
Imaging of fatty acid (FA) trafficking revealed that FAs stored in lipid droplets were delivered to mitochondria when the cells were starved. This delivery required cytoplasmic lipases and mitochondrial fusion activity, whereas lipid droplets were ...
Sarah Cohen, Angelika S. Rambold, Jennifer Lippincott-Schwartz   +2 more
doaj   +1 more source

Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

Nature Communications, 2022
Sidarala et al. examine the importance of the mitochondrial structural proteins, Mitofusins 1 and 2 (Mfn1/2), in diabetes. They find that Mfn1/2 control blood glucose by preserving mitochondrial DNA content, rather than mitochondrial structure.
Vaibhav Sidarala, Jie Zhu, Elena Levi-D’Ancona, Gemma L. Pearson, Emma C. Reck, Emily M. Walker, Brett A. Kaufman, Scott A. Soleimanpour   +7 more
doaj   +1 more source

The investigation on the role of mitochondrial fusion protein 1 in the development of myopia

Indian Journal of Ophthalmology, 2016
Purpose: The aim of this study is to preliminarily investigate the expression of mitochondrial fusion protein 1 (MFN1) in a lens-induced animal myopia (LIM) model and to explore the relationship between MFN1 and the visual development.
Yun-Lin Cai, Yun-Chun Zou, Jia-Hong Lei, Guan-Peng Zeng, Ying Wang   +4 more
doaj   +1 more source

OPA1 supports mitochondrial dynamics and immune evasion to CD8+ T cell in lung adenocarcinoma [PDF]

PeerJ, 2022
Background Mitochondrial fusion and fission were identified to play key roles during multiple biology process. Thus, we aim to investigate the roles of OPA1 in mitochondria fusion and immune evasion of non-small cell lung cancer cells.
Ying Wang, Yadong Li, Xuanwei Jiang, Yayun Gu, Hui Zheng, Xiaoxuan Wang, Haotian Zhang, Jixiang Wu, Yang Cheng   +8 more
doaj   +2 more sources

Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. [PDF]

PLoS Pathogens, 2015
Mitochondria are highly dynamic subcellular organelles participating in many signaling pathways such as antiviral innate immunity and cell death cascades. Here we found that mitochondrial fusion was impaired in dengue virus (DENV) infected cells.
Chia-Yi Yu, Jian-Jong Liang, Jin-Kun Li, Yi-Ling Lee, Bi-Lan Chang, Chan-I Su, Wei-Jheng Huang, Michael M C Lai, Yi-Ling Lin   +8 more
doaj   +1 more source

تاثیر هشت هفته برنامه آماده‏سازی فوتبال و مصرف مکمل بتاولگاریس بر محتوای پروتئین‏های OPA1 و MFN1 بازیکنان فوتبال [PDF]

مطالعات کاربردی علوم زیستی در ورزش, 2023
زمینه و هدف: از آنجا که خستگی جسمی ناشی از انجام فعالیت‎ ورزشی طاقت فرسا، بر ساختار و عملکرد سیستم ایمنی تاثیر منفی می‏ گذارد؛ اتخاذ تدابیر تغذیه ای برای تعویق خستگی و ممانعت از افت عملکرد سیستم ایمنی، پیشنهاد می شود.
محمدمهدی منشی, مهرداد فتحی, سید رضا عطارزاده حسینی, محمد مسافری ضیاءالدینی   +3 more
doaj   +1 more source