Results 11 to 20 of about 11,082 (189)

Loss of Mfn1 but not Mfn2 enhances adipogenesis. [PDF]

PLoS ONE
ObjectiveA biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte differentiation, growth and/or ...
Jake P Mann, Luis Carlos Tábara, Satish Patel, Pushpa Pushpa, Anna Alvarez-Guaita, Liang Dong, Afreen Haider, Koini Lim, Panna Tandon, Fabio Scurria, James E N Minchin, Stephen O'Rahilly S, Daniel J Fazakerley, Julien Prudent, Robert K Semple, David B Savage   +15 more
doaj   +6 more sources

Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer

Pharmacogenomics and Personalized Medicine, 2021
Xiaohua Liang,1 Shengqiang Dang2 1Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China; 2Department of Oncology, Chang’an Hospital of Xi’an, Xi&
Liang X, Dang S
doaj   +4 more sources

MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model

iScience, 2023
Summary: Charcot-Marie-Tooth disease type 2A (CMT2A), the most common inherited peripheral axonal neuropathy, is associated with more than 100 dominant mutations, including R94Q as the most abundant mutation in the Mitofusin2 (MFN2) gene.
Saba Shahin, Bin Lu, Yueqin Zhou, Hui Xu, Jason Chetsawang, Robert H. Baloh, Shaomei Wang   +6 more
doaj   +4 more sources

A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: Implications for cellular health and diseases

Saudi Pharmaceutical Journal
The mitochondria are responsible for the production of cellular ATP, the regulation of cytosolic calcium levels, and the organization of numerous apoptotic proteins through the release of cofactors necessary for the activation of caspases.
Adel Alghamdi
exaly   +4 more sources

Gemini-Based Lipoplexes Complement the Mitochondrial Phenotype in MFN1-Knockout Mouse Embryonic Fibroblasts [PDF]

Molecular Pharmaceutics, 2019
Mitochondria form a dynamic network of constantly dividing and fusing organelles. The balance between these antagonistic processes is crucial for normal cellular function and requires the action of specialized proteins. The mitochondrial membrane proteins mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are responsible for the fusion of the outer membrane of ...
Mónica Muñoz-Úbeda, Andrés Tolosa-Díaz, Santanu Bhattacharya, Elena Junquera, Emilio Aicart, Paolo Natale, Iván López-Montero   +6 more
core   +6 more sources

MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1 [PDF]

Immunologic Research
IgA nephropathy is characterized by the deposition of IgA and complement C3 in the glomerular mesangial region. Recent research has pointed out the critical role of mitochondrial damage during the occurrence and development of IgAN. During IgAN progression, elevated myc promotes the transcription of HRD1, which in turn induces the ubiquitination of ...
Xueping Wu
exaly   +5 more sources

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development [PDF]

The Journal of Cell Biology, 2003
Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown. The mitofusins, Mfn1 and Mfn2, have been shown to affect mitochondrial morphology when overexpressed. We find that mice deficient in either Mfn1 or Mfn2 die in midgestation.
Chen, Hsiuchen, Detmer, Scott A., Ewald, Andrew J., Griffin, Erik E., Fraser, Scott E., Chan, David C.   +5 more
openaire   +5 more sources

The GDP-Bound State of Mitochondrial Mfn1 Induces Membrane Adhesion of Apposing Lipid Vesicles through a Cooperative Binding Mechanism

Biomolecules, 2020
Mitochondria are double-membrane organelles that continuously undergo fission and fusion. Outer mitochondrial membrane fusion is mediated by the membrane proteins mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2), carrying a GTP hydrolyzing domain (GTPase) and ...
Andrés Tolosa-Díaz, Víctor G. Almendro-Vedia, Paolo Natale, Iván López-Montero   +3 more
doaj   +3 more sources

Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia

Antioxidants, 2022
The present study was conducted to evaluate the effect of genipin (GEN) on the microglia of diabetic cognitive impairment and explore its potential mechanism.
Wanying Liu, Ke Li, Menglin Zheng, Ling He, Tong Chen   +4 more
doaj   +2 more sources

REEP5-MFN1/2 tethering in ER-mitochondria crosstalk [PDF]

Eukaryotic cells utilize membrane contact sites (MCSs) to mediate communication between organelles, with mitochondria-ER contact sites (MERCs) being among the most extensively studied due to their essential roles in maintaining cellular homeostasis. MERCs facilitate critical processes, including lipid biosynthesis, calcium transfer, and mitochondrial ...
Sun, Yang
openaire   +2 more sources