Results 31 to 40 of about 11,082 (189)
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion
Nature Communications, 2022 AbstractMitochondria generate ATP and play regulatory roles in various cellular activities. Cancer cells often exhibit fragmented mitochondria. However, the underlying mechanism remains elusive. Here we report that a mitochondrial protein FUN14 domain containing 2 (FUNDC2) is transcriptionally upregulated in primary mouse liver tumors, and in ...
Shuaifeng Li +14 more
openaire +3 more sources
Heptad repeat regions of coiled-coil domains of Mfn1 are crucial for Mfn1 mediated mitochondrial fusion [PDF]
, 2018 Mitofusin mediate fusion of outer mitochondrial membranes (OMM). Recent studies have explained the role of GTPase domain for Mfn1 dimerization and outer mitochondrial membrane (OMM) fusion. Coiled-coiled domains [namely, coiled-coil/Middle domains (CC1MD) and coiled-coil-2 GTPase effector domain (CC2/GED)] form helical bundles that mediate open-to ...
Sinha, Sansrity +1 more
openaire +1 more source
The effects of endurance training and estrogen-related receptor α disruption on mitofusin 1 and 2, GLUT2, PPARβ/δ and SCD1 expression in the liver of diabetic rats [PDF]
The Ukrainian Biochemical Journal, 2020 Diabetes is a progressive and metabolic disease with a high prevalence throughout the world. Physical activity is considered as an intervention to improve diabetes. Intervention such as estrogen-related receptor α (ERRα) inhibition is considered as a new
B. Shahouzehi +3 more
doaj +1 more source
Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking
Molecular & Cellular Oncology, 2018 Imaging of fatty acid (FA) trafficking revealed that FAs stored in lipid droplets were delivered to mitochondria when the cells were starved. This delivery required cytoplasmic lipases and mitochondrial fusion activity, whereas lipid droplets were ...
Sarah Cohen +2 more
doaj +1 more source
Nature Communications, 2022 Sidarala et al. examine the importance of the mitochondrial structural proteins, Mitofusins 1 and 2 (Mfn1/2), in diabetes. They find that Mfn1/2 control blood glucose by preserving mitochondrial DNA content, rather than mitochondrial structure.
Vaibhav Sidarala +7 more
doaj +1 more source
Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2
Molecular Biology of the Cell, 2019 Mitochondrial structure can be maintained at steady state or modified in response to changes in cellular physiology. This is achieved by the coordinated regulation of dynamic properties including mitochondrial fusion, division, and transport. Disease states, including neurodegeneration, are associated with defects in these processes.
Sloat, SR +3 more
openaire +2 more sources
OPA1 supports mitochondrial dynamics and immune evasion to CD8+ T cell in lung adenocarcinoma [PDF]
PeerJ, 2022 Background Mitochondrial fusion and fission were identified to play key roles during multiple biology process. Thus, we aim to investigate the roles of OPA1 in mitochondria fusion and immune evasion of non-small cell lung cancer cells.
Ying Wang +8 more
doaj +2 more sources
MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria [PDF]
Journal of Cell Science, 2014 Fasting and glucose shortage activate a metabolic switch that shifts more energy production to mitochondria. This metabolic adaptation ensures energy supply, but also elevates the risk of mitochondrial oxidative damage. Here we present evidence that metabolically challenged mitochondria undergo active fusion to suppress oxidative stress. In response to
Joo-Yong, Lee +9 more
openaire +2 more sources