Paper de les proteïnes de fusió mitocondrial Opa1 i Mfn1 durant la diferenciació miogènica [PDF]
, 2014 Les mitocòndries generen la major part de l'energia necessària per a la funció cel·lular mitjançant la respiració i la fosforilació oxidativa. Quan els mioblasts diferencien a miotubs, la biogènesi mitocondrial i l'activitat enzimàtica mitocondrial ...
Noguera Jordà, Eduard +1 more
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DENV infection suppresses MFN1-mediated mitochondrial dynamics.
, 2016 (A) Anti-HA and MitoTracker staining of intracellular localization of ectopic-expressed MFN1 and mitochondrial morphology in A549+on/HA-MFN1 cells treated with or without Dox (1 μg/ml, 24 h).
Yi-Ling Lee (155311) +8 more
core +1 more source
STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion
Frontiers in Cell and Developmental Biology, 2021 Ferroptosis is a type of iron-dependent regulated cell death caused by the disruption that occurs when oxidative stress and antioxidant defenses interact, and then driven by lipid peroxidation and subsequent plasma membrane ruptures.
Changfeng Li +5 more
doaj +1 more source
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1 [PDF]
Immunologic ResearchXueping Wu
exaly +2 more sources
MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion
EMBO Reports, 2023 Fusion of the outer mitochondrial membrane (OMM) is regulated by mitofusin 1 (MFN1) and 2 (MFN2), yet the differential contribution of each of these proteins is less understood.
Andres Goldman +5 more
doaj +1 more source
Mitofusin 1 is degraded at G2/M phase through ubiquitylation by MARCH5
Cell Division, 2012 Background Mitochondria exhibit a dynamic morphology in cells and their biogenesis and function are integrated with the nuclear cell cycle. In mitotic cells, the filamentous network structure of mitochondria takes on a fragmented form.
Park Yong-Yea, Cho Hyeseong
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REEP5-MFN1/2 tethering in ER-mitochondria crosstalk [PDF]
Eukaryotic cells utilize membrane contact sites (MCSs) to mediate communication between organelles, with mitochondria-ER contact sites (MERCs) being among the most extensively studied due to their essential roles in maintaining cellular homeostasis ...
Sun, Yang
core +1 more source
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development [PDF]
, 2003 Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown.
Ewald , Andrew J. +17 more
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Effect of knockdown of Mfn1 or PGC-1α.
, 2021 (A) MCF7 cells transfected with siRNA for Mfn1 were subjected to digitonin fractionation as described in the Materials and Methods and whole cell lysate (WCL), pellets (ppt) or cytosolic extracts (cyto) were blotted using the indicated antibodies.
Fusako Ikeda (361733) +5 more
core +1 more source
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
Nature Communications, 2019 We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1 ...
Julio C. B. Ferreira +11 more
doaj +1 more source