Results 31 to 40 of about 3,871 (146)
Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking
Molecular & Cellular Oncology, 2018 Imaging of fatty acid (FA) trafficking revealed that FAs stored in lipid droplets were delivered to mitochondria when the cells were starved. This delivery required cytoplasmic lipases and mitochondrial fusion activity, whereas lipid droplets were ...
Sarah Cohen +2 more
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Cell Death and Disease, 2022 Neuronal mitochondrial dynamics are disturbed after ischemic stroke. Optic atrophy 1 (OPA1) and its GTPase activity are involved in maintaining mitochondrial cristae and inner membrane fusion.
Xiang Li +8 more
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Redox Biology, 2020 Background: Ischemic stroke can induce changes in mitochondrial morphology and function. As a regulatory gene in mitochondria, optic atrophy 1 (OPA1) plays a pivotal role in the regulation of mitochondrial dynamics and other related functions.
Yongxing Lai +11 more
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Antioxidants, 2022 Flow (shear stress)-mediated dilation (FMD) of resistance arteries is a rapid endothelial response involved in tissue perfusion. FMD is reduced early in cardiovascular diseases, generating a major risk factor for atherosclerosis.
Ahmad Chehaitly +15 more
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Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation
iScience, 2020 Summary: Optic atrophy 1 (OPA1), a GTPase at the inner mitochondrial membrane involved in regulating mitochondrial fusion, stability, and energy output, is known to be crucial for neural development: Opa1 heterozygous mice show abnormal brain development,
Safak Caglayan +15 more
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Activation of OPA1 Processing in Differentiated Myoblast Cells [PDF]
, 2023 Mitochondria are eukaryotic cellular organelles that play a role in energy production, apoptosis, integrated stress response, and aging. Mitochondrial dynamics is the physical fusion (interconnection) and fission (fragmentation) of mitochondria within a ...
Carrillo, Omar Agustin
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Redox Biology, 2023 During cardiac ischemia-reperfusion, excess reactive oxygen species can damage mitochondrial, cellular and organ function. Here we show that cysteine oxidation of the mitochondrial protein Opa1 contributes to mitochondrial damage and cell death caused by
Martina Semenzato +9 more
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Opa1 is required for proper mitochondrial metabolism in early development. [PDF]
PLoS ONE, 2013 Opa1 catalyzes fusion of inner mitochondrial membranes and formation of the cristae. OPA1 mutations in humans lead to autosomal dominant optic atrophy. OPA1 knockout mice lose viability around embryonic day 9 from unknown reasons, indicating that OPA1 is
Jennifer J Rahn +2 more
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Autosomal dominant optic atrophy: A novel treatment for OPA1 splice defects using U1 snRNA adaption
Molecular Therapy: Nucleic Acids, 2021 Autosomal dominant optic atrophy (ADOA) is frequently caused by mutations in the optic atrophy 1 (OPA1) gene, with haploinsufficiency being the major genetic pathomechanism. Almost 30% of the OPA1-associated cases suffer from splice defects.
Christoph Jüschke +5 more
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OPA1 increases the risk of normal but not high tension glaucoma
, 2010 Background Primary open angle glaucoma is a progressive optic neuropathy characterised by the selective loss of retinal ganglion cells, pathological optic disc cupping and visual field defects.
Griffiths, P. G. +6 more
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