Results 11 to 20 of about 25,822 (292)
OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions [PDF]
Cell Reports, 2017 Summary: OPA1 is a GTPase that controls mitochondrial fusion, cristae integrity, and mtDNA maintenance. In humans, eight isoforms are expressed as combinations of long and short forms, but it is unclear whether OPA1 functions are associated with specific
Valentina Del Dotto +2 more
exaly +6 more sources
OPA1, a molecular regulator of dilated cardiomyopathy
Journal of Cellular and Molecular Medicine, 2023 Dilated cardiomyopathy (DCM) is a disease with no specific treatment, poor prognosis and high mortality. During DCM development, there is apoptosis, mitochondrial dynamics imbalance and changes in cristae structure. Optic atrophy 1 (OPA1) appears at high
Jiaqi Chen +4 more
semanticscholar +3 more sources
OPA1 helical structures give perspective to mitochondrial dysfunction
Nature, 2023 Cryo-electron microscopy structures of OPA1, mutations of which are associated with the disease dominant optic atrophy, provide insight into how structural features of OPA1 enable this protein to mediate mitochondrial-membrane fusion and remodelling ...
Sarah B. Nyenhuis +9 more
semanticscholar +3 more sources
OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution
Cell Death and DiseaseOptic atrophy protein 1 (OPA1) mediates inner mitochondrial membrane (IMM) fusion and cristae organization. Mutations in OPA1 cause autosomal dominant optic atrophy (ADOA), a leading cause of blindness.
J. Macuada +11 more
doaj +2 more sources
OPA1 functions in mitochondria and dysfunctions in optic nerve [PDF]
The International Journal of Biochemistry & Cell Biology, 2009 OPA1 is the major gene responsible for Dominant Optic Atrophy (DOA), a blinding disease that affects specifically the retinal ganglion cells (RGCs), which function consists in connecting the neuro-retina to the brain.
A. Olichon +9 more
core +5 more sources
Structural and evolutionary characteristics of dynamin-related GTPase OPA1 [PDF]
PeerJ, 2019 OPA1 is a dynamin-related GTPase that controls mitochondrial fusion, cristae remodeling, energetics and mtDNA maintenance. However, the molecular architecture of OPA1 is poorly understood.
Dandan Li +3 more
doaj +4 more sources
OPA1 in Cardiovascular Health and Disease [PDF]
Current Drug Targets, 2015 Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype ...
Niall, Burke +2 more
openaire +4 more sources
Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity
Frontiers in Bioscience-Landmark, 2022 Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China.
Jinling Wang +6 more
doaj +1 more source
OPA1 and Angiogenesis: Beyond the Fusion Function [PDF]
Cell Metabolism, 2020 In this issue of Cell Metabolism, Herkenne et al. (2020) show that the mitochondrial fusion protein OPA1 promotes angiogenesis independent of its function in mitochondrial dynamics, identifying a key new therapeutic target to prevent vascular growth during development and tumor formation.
Max-Hinderk, Schuler, Adam L, Hughes
openaire +2 more sources
Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat
Disease Models & Mechanisms, 2022 Impaired thermogenesis observed in mice with whole-body ablation of peroxisome proliferator-activated receptor-γ coactivator-1β (PGC-1β; officially known as PPARGC1B) may result from impaired brown fat (brown adipose tissue; BAT) function, but other ...
Jiří Funda +10 more
doaj +1 more source