Results 11 to 20 of about 15,870 (189)
Mitochondrial Membrane Dynamics—Functional Positioning of OPA1
Antioxidants, 2018 The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion.
Hakjoo Lee, Yisang Yoon, Yoon Yisang
exaly +4 more sources
OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions [PDF]
Cell Reports, 2017 Summary: OPA1 is a GTPase that controls mitochondrial fusion, cristae integrity, and mtDNA maintenance. In humans, eight isoforms are expressed as combinations of long and short forms, but it is unclear whether OPA1 functions are associated with specific
Valentina Del Dotto +2 more
exaly +4 more sources
OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling
Frontiers in Cell and Developmental Biology, 2022 Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cristae ...
Benjamín Cartes-Saavedra +11 more
doaj +3 more sources
Redox Biology, 2021 Background: Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are linked to several mitochondrial alterations. Cigarette smoke (CS) alters the structure and function of mitochondria.
Krishna P Maremanda +2 more
exaly +3 more sources
Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth [PDF]
Journal of Experimental & Clinical Cancer Research, 2022 Background Mitochondrial fusion and fission proteins have been nominated as druggable targets in cancer. Whether their inhibition is efficacious in triple negative breast cancer (TNBC) that almost invariably develops chemoresistance is unknown.
Margherita Zamberlan +13 more
doaj +2 more sources
In situ architecture of Opa1-dependent mitochondrial cristae remodeling
The EMBO JournalCristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms in the mitochondrion, a membrane-anchored long form (l ...
Michelle Y Fry +17 more
doaj +2 more sources
Opa1 is required for proper mitochondrial metabolism in early development. [PDF]
PLoS ONE, 2013 Opa1 catalyzes fusion of inner mitochondrial membranes and formation of the cristae. OPA1 mutations in humans lead to autosomal dominant optic atrophy. OPA1 knockout mice lose viability around embryonic day 9 from unknown reasons, indicating that OPA1 is
Jennifer J Rahn +2 more
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Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production [PDF]
Nature Communications, 2018 Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections.
Poorya Amini +12 more
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Integrated bioinformatic and in vivo analysis confirms the cardioprotective role of OPA1 [PDF]
BMC Cardiovascular DisordersBackground OPA1 is an inner mitochondrial membrane protein that mediates diverse signaling processes. OPA1 is important for cardiac function and protects against cardiac insults such as ischemia/reperfusion injury.
Claire Fong-McMaster +15 more
doaj +2 more sources
Structural and evolutionary characteristics of dynamin-related GTPase OPA1 [PDF]
PeerJ, 2019 OPA1 is a dynamin-related GTPase that controls mitochondrial fusion, cristae remodeling, energetics and mtDNA maintenance. However, the molecular architecture of OPA1 is poorly understood.
Dandan Li +3 more
doaj +3 more sources