Results 51 to 60 of about 3,871 (146)

The effect of ethyl acetate extract from Atractylis flava Desf. on the gene expression of pro-inflammatory cytokines and oxidative stress markers in NR8383 alveolar rat macrophage cells

Current Issues in Pharmacy and Medical Sciences
Atractylis flava Desf. (AF) is common plant that is widely used for its anti- inflammatory and antioxidant properties. The purpose of this study was, therefore, to evaluate the cytotoxic effect and the molecular basis of antioxidant and anti-inflammatory
Melakhessou Mohamed Akram, Eddine Marref Salah, Zahra Doumandji, Ramia Safar, Marref Cherine, Imene Becheker, Olivier Joubert   +6 more
doaj   +1 more source

Structural and evolutionary characteristics of dynamin-related GTPase OPA1 [PDF]

PeerJ, 2019
OPA1 is a dynamin-related GTPase that controls mitochondrial fusion, cristae remodeling, energetics and mtDNA maintenance. However, the molecular architecture of OPA1 is poorly understood.
Dandan Li, Jinlan Wang, Zichen Jin, Zheng Zhang   +3 more
doaj   +2 more sources

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Melanopsin expression in Opa1^+/+ and Opa1^+/− retinae.

, 2013
Overall distribution of melanopsin-positive RGCs in a flatmount retina from (A) Opa1+/+ and (B) Opa1+/− mice. The total number of melanopsin expressing cells was not significantly different between genotypes (Opa1+/+: n = 3; Opa1+/: n = 3).
Georgia Perganta (284129), Christiana Katti (173404), Athanasios Vachtsevanos (284131), Robert E. MacLaren (170328), Marcela Votruba (284133), Alun R. Barnard (284130), Sumathi Sekaran (173416), Ron H. Douglas (284132)   +7 more
core   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Genomic deletions in OPA1 in Danish patients with autosomal dominant optic atrophy

BMC Medical Genetics, 2011
Background Autosomal dominant optic atrophy (ADOA, Kjer disease, MIM #165500) is the most common form of hereditary optic neuropathy. Mutations in OPA1 located at chromosome 3q28 are the predominant cause for ADOA explaining between 32 and 89% of cases ...
Larsen Michael, Milea Dan, Grønskov Karen, Almind Gitte J, Brøndum-Nielsen Karen, Ek Jakob   +5 more
doaj   +1 more source

p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer

Acta Biochimica et Biophysica Sinica, 2023
Cisplatin resistance is a major obstacle in the treatment of non-small cell lung cancer (NSCLC). p32 and OPA1 are the key regulators of mitochondrial morphology and function. This study aims to investigate the role
Yu Chun-Xia, Peng Zhe-Qing, Wang Tao, Qu Xin-Hui, Yang Ping, Huang Shao-Rong, Jiang Li-Ping, Tou Fang-Fang, Han Xiao-Jian   +8 more
doaj   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Brain-specific disruption of OPA1 processing.

, 2014
(A) Levels of autophagy markers are unchanged in P33 HTRA2 KO brain. The LC3β-II to LC3β-I ratio is unchanged in P33 brain and there is no accumulation of P62 (n = 3). Actin is included as a loading control. (B) Processing of OPA1 was altered in HTRA2 KO
Alfred J. Zullo (678437), Claire Koenig (678438), Chia-Yi Kuan (43977), Jinah Han (678439), Sean Stoessel (677279), Xinran Liu (365526), Murim Choi (147853), Victoria L. Patterson (678436), Jean-Leon Thomas (678440), Hakryul Jo (249932), Andrew T. DeWan (128762), Josephine Hoh (128765)   +11 more
core   +1 more source

Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria

Redox Biology, 2021
Reactive oxygen species (ROS) are a common product of active mitochondrial respiration carried in mitochondrial cristae, but whether cristae shape influences ROS levels is unclear.
Rubén Quintana-Cabrera, Israel Manjarrés-Raza, Carlos Vicente-Gutiérrez, Mauro Corrado, Juan P. Bolaños, Luca Scorrano   +5 more
doaj   +1 more source