Results 51 to 60 of about 15,870 (189)

OPA1 increases the risk of normal but not high tension glaucoma

, 2010
Background Primary open angle glaucoma is a progressive optic neuropathy characterised by the selective loss of retinal ganglion cells, pathological optic disc cupping and visual field defects.
Griffiths, P. G., Birch, M. K., Andrews, R. M., Chinnery, P. F., Hudson, G., Yu-Wai-Man, P., Stewart, J .D.   +6 more
core   +1 more source

Validation of OPA1 KD.

, 2023
The amounts of OPA1 mRNA were measured by quantitative RT-PCR and normalized by Actin mRNA levels. Error bars indicate standard errors from duplicated samples of quantitative PCR. Source data can be found in S16 Data. **p t test.
Koki Nakamura (5340158), Yu Nakanishi (10924804), Bruno M. Humbel (6194645), Hiroki Kawai (1603030), Shogo Suga (16913675), Yusuke Hirabayashi (565072)   +5 more
core   +1 more source

Structural mechanism of mitochondrial membrane remodelling by human OPA1 [PDF]

, 2023
Distinct morphologies of the mitochondrial network support divergent metabolic and regulatory processes that determine cell function and fate1-3.
Malsburg, A., Matteo Dal Peraro, Sapp, Gracie M., Sapp, Gracie, Dal Peraro, Matteo, Zuccaro, K., Zuccaro, Kelly, Kelly E. Zuccaro, Aydin, H., Kalia, R., Laan, M., Moss, F., Kalia, Raghav, van der Laan, Martin, Halil Aydin, Alexander von der Malsburg, Raghav Kalia, Adam Frost, Peraro, M., Aydin, Halil, Zuccaro, Kelly E., Luciano A. Abriata, Gracie M. Sapp, Frost, Adam, Moss, Frank, Frost, A., Martin van der Laan, Bennett, J., Alexander von Appen, Bennett, Jeremy, von Appen, Alexander, Abriata, L., Abriata, Luciano, Sapp, G., Appen, A., Frank R. Moss, Jeremy A. Bennett, Abriata, Luciano Andres, von der Malsburg, Alexander, Moss, Frank R., Bennett, Jeremy A.   +40 more
core   +1 more source

Does Disruption of Optic Atrophy-1 (OPA1) Contribute to Cell Death in HL-1 Cardiomyocytes Subjected to Lethal Ischemia-Reperfusion Injury?

Cells, 2022
Disruption of mitochondrial structure/function is well-recognized to be a determinant of cell death in cardiomyocytes subjected to lethal episodes of ischemia-reperfusion (IR). However, the precise mitochondrial event(s) that precipitate lethal IR injury
Andrew R. Kulek, Vishnu V. R. Undyala, Anthony R. Anzell, Sarita Raghunayakula, Lee Ann MacMillan-Crow, Thomas H. Sanderson, Karin Przyklenk   +6 more
doaj   +1 more source

The Effect of 4 Weeks of Aerobic Training on Spatial Learning, Memory Performance and Mitochondrial Dynamics in the Hippocampal Tissue of Old Rats

Journal of Ardabil University of Medical Sciences, 2020
Background & objectives: Mitochondrial dysfunction is one of the main risk factors for neurological diseases which are associated with aging. On the other hand, aerobic exercise has beneficial effects on the brain health and cognitive function, and also ...
Ahmad Fazeli Sani, Hasan Matin homaee, Abdolali Banaeifar   +2 more
doaj  

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control

Frontiers in Cell and Developmental Biology, 2020
Mitochondrial dysfunction contributes to cardiovascular disorders, especially post-infarction cardiac injury, through incompletely characterized mechanisms.
Ting Xin, Wei Lv, Dongmei Liu, Yongle Jing, Fang Hu   +4 more
doaj   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

: OPA1 deficit and cardiac mitochondria

, 2012
International audienceAIMS: The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the heart is largely unknown. We investigated the
Fortin, Dominique, Ventura-Clapier, Renée, Caffin, Fanny, Veksler, Vladimir, Novotova, Marta, Garnier, Anne, Alavi, Marcel, V., Joubert, Frédéric, Huynh, Le Ha, Piquereau, Jerome, Prola, Alexandre, Nicolas, Valérie, Brenner, Catherine, Mateo, Philippe   +13 more
core   +1 more source

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source